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  1. Efficient in vivo delivery of a CRISPR/Cas9 plasmid is of paramount importance for effective therapy. Here, we investigated the usability of Salmonella as a plasmid carrier for in vivo therapy against virus-induc...

    Authors: Amal Senevirathne, Chamith Hewawaduge and John Hwa Lee
    Citation: Veterinary Research 2021 52:125
  2. The parasitic gastrointestinal nematode Haemonchus contortus causes serious economic losses to agriculture due to infection and disease in small ruminant livestock. The development of new therapies requires appro...

    Authors: Linh Thuy Nguyen, Markéta Zajíčková, Eva Mašátová, Petra Matoušková and Lenka Skálová
    Citation: Veterinary Research 2021 52:124
  3. Salmonella enterica ssp. enterica serovars Enteritidis (SE) and Gallinarum (SG) cause different diseases in chickens. However, both are able to reach the blood stream where heterophils and monocytes are potential...

    Authors: Sravya Sreekantapuram, Christian Berens, Stefanie A. Barth, Ulrich Methner and Angela Berndt
    Citation: Veterinary Research 2021 52:123
  4. Mastitis is a complex inflammatory disease caused by pathogenic infection of mammary tissue in dairy cows. The molecular mechanism behind its occurrence, development, and regulation consists of a multi-gene ne...

    Authors: Zhuo-Ma Luoreng, Da-Wei Wei and Xing-Ping Wang
    Citation: Veterinary Research 2021 52:122

    The Correction to this article has been published in Veterinary Research 2021 52:136

  5. The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic is causing a global crisis. It is still unresolved. Although many therapies and vaccines are being studied, they are still in their inf...

    Authors: Myeon-Sik Yang, Byung Kwan Oh, Daram Yang, Eun Young Oh, Yeonhwa Kim, Kyung Won Kang, Chae Woong Lim, Gou Young Koh, Sang-Myeong Lee and Bumseok Kim
    Citation: Veterinary Research 2021 52:121
  6. Gyrovirus 3 (GyV3), the third novel emerging species of the genus Gyrovirus of the Anelloviridae family, has been described in multiple hosts. Epidemiologically, there are suggestions that GyV3 is associated with...

    Authors: Gen Li, Defang Zhou, Manda Zhao, Qing Liu, Xiaojing Hao, Tianxing Yan, Shiyu Yuan, Shicheng Zhang and Ziqiang Cheng
    Citation: Veterinary Research 2021 52:120
  7. Congenital avian leukosis virus subgroup J (ALV-J) infection can induce persistent immunotolerance in chicken, however, the underlying mechanism remains unclear. Here, we demonstrate that congenital ALV-J infe...

    Authors: Shuhai He, Gaoying Zheng, Defang Zhou, Li Huang, Jianguo Dong and Ziqiang Cheng
    Citation: Veterinary Research 2021 52:119
  8. Escherichia coli (E. coli) O157:H7 bacterial infection causes severe disease in mammals and results in substantial economic losses worldwide. Due to the development of antibiotic resistance, bacteriophage (phage)...

    Authors: Hanjie Yin, Jing Li, Haosheng Huang, Yuxin Wang, Xinjie Qian, Jianluan Ren, Feng Xue, Jianjun Dai and Fang Tang
    Citation: Veterinary Research 2021 52:118
  9. Edwardsiella tarda is a facultative intracellular pathogen in humans and animals. The Gram-negative bacterium is widely considered a potentially important bacterial pathogen. Adaptation to acid stress is importan...

    Authors: Chunmei Du, Xiaoping Huo, Hanjie Gu, Dongmei Wu and Yonghua Hu
    Citation: Veterinary Research 2021 52:117
  10. The management of infectious diseases in wildlife reservoirs is challenging and faces several limitations. However, detailed knowledge of host–pathogen systems often reveal heterogeneity among the hosts’ contr...

    Authors: Sébastien Lambert, Anne Thébault, Sophie Rossi, Pascal Marchand, Elodie Petit, Carole Toïgo and Emmanuelle Gilot-Fromont
    Citation: Veterinary Research 2021 52:116
  11. The spread of chronic wasting disease (CWD) during the last six decades has resulted in cervid populations of North America where CWD has become enzootic. This insidious disease has also been reported in wild ...

    Authors: Alicia Otero, Camilo Duque Velásquez, Judd Aiken and Debbie McKenzie
    Citation: Veterinary Research 2021 52:115
  12. Biofilm formation is a significant virulence factor in Staphylococcus (S.) aureus strains causing subclinical mastitis in dairy cows. A role of environmental signals and communication systems in biofilm developme...

    Authors: Bruno Toledo-Silva, Fernando N. de Souza, Kristien Mertens, Sofie Piepers, Freddy Haesebrouck and Sarne De Vliegher
    Citation: Veterinary Research 2021 52:114
  13. The aim of this study was to investigate the biological properties of a novel gut-specific cysteine protease in Trichinella spiralis (TsGSCP) and its role in larval intrusion, development and fecundity. TsGSCP ha...

    Authors: Yuan Yuan Hu, Ru Zhang, Shu Wei Yan, Wen Wen Yue, Jia Hang Zhang, Ruo Dan Liu, Shao Rong Long, Jing Cui and Zhong Quan Wang
    Citation: Veterinary Research 2021 52:113
  14. A vaccine protecting against different Streptococcus suis serotypes is highly needed in porcine practice to improve animal welfare and reduce the use of antibiotics. We hypothesized that immunogens prominently re...

    Authors: Christine Weiße, Denise Dittmar, Beata Jakóbczak, Volker Florian, Nicole Schütze, Gottfried Alber, Kristin Klose, Stephan Michalik, Peter Valentin-Weigand, Uwe Völker and Christoph Georg Baums
    Citation: Veterinary Research 2021 52:112
  15. Salmonid rickettsial septicaemia (SRS) is a contagious disease caused by Piscirickettsia salmonis, an intracellular bacterium. SRS causes an estimated economic loss of $700 million USD to the Chilean industry ann...

    Authors: Mario Caruffo, Sonia Vidal, Leonardo Santis, Daniela Siel, Oliver Pérez, Paula R. Huenchullan and Leonardo Sáenz
    Citation: Veterinary Research 2021 52:111
  16. This study aimed to explore the mutual regulation between chicken telomerase reverse transcriptase (chTERT) and the Wnt/β-catenin signalling pathway and its effects on cell growth and avian leukosis virus subg...

    Authors: Yong Xiang, Yun Yu, Qingbo Li, Zeng Jiang, Jinqun Li, Canxin Liang, Jian Chen, Yu Li, Xiaoyan Chen and Weisheng Cao
    Citation: Veterinary Research 2021 52:110
  17. Salmonella enterica serotype Enteritidis (SE) is a zoonotic pathogen which causes foodborne diseases in humans as well as severe disease symptoms in young chickens. More insight in innate and adaptive immune resp...

    Authors: Nathalie Meijerink, Robin H. G. A. van den Biggelaar, Daphne A. van Haarlem, J. Arjan Stegeman, Victor P. M. G. Rutten and Christine A. Jansen
    Citation: Veterinary Research 2021 52:109
  18. Breeding bulls infected with Besnoitia besnoiti may develop sterility during either acute or chronic infection. The aim of this study was to investigate the molecular pathogenesis of B. besnoiti infection with pr...

    Authors: David González-Barrio, Carlos Diezma-Díaz, Daniel Gutiérrez-Expósito, Enrique Tabanera, Alejandro Jiménez-Meléndez, Manuel Pizarro, Marta González-Huecas, Ignacio Ferre, Luis M. Ortega-Mora and Gema Álvarez-García
    Citation: Veterinary Research 2021 52:106
  19. Prion diseases are transmissible spongiform encephalopathies induced by the abnormally-folded prion protein (PrPSc), which is derived from the normal prion protein (PrPC). Previous studies have reported that lipi...

    Authors: Yong-Chan Kim, Junbeom Lee, Dae-Weon Lee and Byung-Hoon Jeong
    Citation: Veterinary Research 2021 52:105
  20. In bovine mammary epithelial cells (BMECs), a cascade of inflammatory reactions induced by lipopolysaccharide (LPS) has been shown to result in cell injury and apoptosis. The present study aims to reveal the p...

    Authors: Mingjiang Liu, Chi Zhang, Xiaolong Xu, Xin Zhao, Ziyi Han, Dandan Liu, Ruonan Bo, Jingui Li and Zongping Liu
    Citation: Veterinary Research 2021 52:104
  21. Nocardioform placentitis (NP) continues to result in episodic outbreaks of abortion and preterm birth in mares and remains a poorly understood disease. The objective of this study was to characterize the trans...

    Authors: Hossam El-Sheikh Ali, Shavahn C. Loux, Laura Kennedy, Kirsten E. Scoggin, Pouya Dini, Carleigh E. Fedorka, Theodore S. Kalbfleisch, Alejandro Esteller-Vico, David W. Horohov, Erdal Erol, Craig N. Carter, Jackie L. Smith and Barry A. Ball
    Citation: Veterinary Research 2021 52:103
  22. Porcine epidemic diarrhea virus (PEDV) is a highly infectious pathogen of watery diarrhea that causes serious economic loss to the swine industry worldwide. Especially because of the high mortality rate in neo...

    Authors: Akitsu Masuda, Jae Man Lee, Takeshi Miyata, Takeru Ebihara, Kohei Kakino, Masato Hino, Ryosuke Fujita, Hiroaki Mon and Takahiro Kusakabe
    Citation: Veterinary Research 2021 52:102
  23. Pathogens could precisely alter their gene expression to facilitate their survival and successful infection. The LuxR family transcriptional regulator DctR (also known as YhiF) was shown to participate in the ...

    Authors: Yaodong Zhang, Yao Wang, Hong Zhu, Zhengfei Yi, Dossêh Jean Apôtre Afayibo, Chenglin Tao, Tao Li, Mingxing Tian, Jingjing Qi, Chan Ding, Shengqing Yu and Shaohui Wang
    Citation: Veterinary Research 2021 52:101
  24. Glässer’s disease is caused by the agent Glaesserella parasuis and is difficult to prevent and control. Candidate screening for subunit vaccines contributes to the prevention of this disease. Therefore, in this s...

    Authors: Kexin Zhu, Dong Yu, Jiahui An and Yufeng Li
    Citation: Veterinary Research 2021 52:100
  25. The immunomodulatory capacity of F. hepatica antigens is probably one of the main reasons for the development of a driven non-protective Th2 immune response. In this study, we analysed the cellular response of he...

    Authors: Raúl Pérez-Caballero, F. Javier Martínez-Moreno, Yolanda Corripio-Miyar, Tom N. McNeilly, Krystyna Cwiklinski, John P. Dalton, Rafael Zafra, José Pérez, Álvaro Martínez-Moreno and Leandro Buffoni
    Citation: Veterinary Research 2021 52:99
  26. Flaviviruses are enveloped single positive-stranded RNA viruses. The capsid (C), a structural protein of flavivirus, is dimeric and alpha-helical, with several special structural and functional features. The f...

    Authors: Xingcui Zhang, Yanting Zhang, Renyong Jia, Mingshu Wang, Zhongqiong Yin and Anchun Cheng
    Citation: Veterinary Research 2021 52:98
  27. Porcine reproductive and respiratory syndrome (PRRS) is a serious disease burdening global swine industry. Infection by its etiological agent, PRRS virus (PRRSV), shows a highly restricted tropism of host cell...

    Authors: Hongfang Ma, Rui Li, Longguang Jiang, Songlin Qiao, Xin-xin Chen, Aiping Wang and Gaiping Zhang
    Citation: Veterinary Research 2021 52:97
  28. Mycoplasma hyopneumoniae is the primary agent of enzootic pneumonia in pigs. Although cell mediated immunity (CMI) may play a role in protection against M. hyopneumoniae, its transfer from sows to their offspring...

    Authors: Evelien Biebaut, Lisa Beuckelaere, Filip Boyen, Freddy Haesebrouck, Charles-Oliver Gomez-Duran, Bert Devriendt and Dominiek Maes
    Citation: Veterinary Research 2021 52:96
  29. Pseudorabies, caused by pseudorabies virus (PRV) variants, has broken out among commercial PRV vaccine-immunized swine herds and resulted in major economic losses to the pig industry in China since late 2011. ...

    Authors: Peng-Fei Fu, Xuan Cheng, Bing-Qian Su, Li-Fang Duan, Cong-Rong Wang, Xin-Rui Niu, Jiang Wang, Guo-Yu Yang and Bei-Bei Chu
    Citation: Veterinary Research 2021 52:95
  30. Small intestinal organoids, or enteroids, represent a valuable model to study host–pathogen interactions at the intestinal epithelial surface. Much research has been done on murine and human enteroids, however...

    Authors: Bjarne Vermeire, Liara M. Gonzalez, Robert J. J. Jansens, Eric Cox and Bert Devriendt
    Citation: Veterinary Research 2021 52:94

    The Correction to this article has been published in Veterinary Research 2021 52:107

  31. Porcine reproductive and respiratory syndrome (PRRS) induces respiratory disease and reproductive failure accompanied by gastroenteritis-like symptoms. The mechanism of intestinal barrier injury caused by PRRS...

    Authors: Jin Zhao, Shuangxiu Wan, Na Sun, Panpan Sun, Yaogui Sun, Ajab Khan, Jianhua Guo, Xiaozhong Zheng, Kuohai Fan, Wei Yin and Hongquan Li
    Citation: Veterinary Research 2021 52:93
  32. Unlike in chickens, dynamics of the gut microbiome in turkeys is limitedly understood and no data were yet published in context of pathological changes following experimental infection. Thus, the impact of Histom...

    Authors: Mohamed Kamal Abdelhamid, Ivan Rychlik, Claudia Hess, Tamas Hatfaludi, Magdalena Crhanova, Daniela Karasova, Julia Lagler, Dieter Liebhart, Michael Hess and Surya Paudel
    Citation: Veterinary Research 2021 52:92
  33. Understanding the mechanisms of transmission of infectious laryngotracheitis virus (ILTV) is critical to proper control as both vaccine and wild-type strains circulate within chicken flocks with potential adve...

    Authors: Addisu A. Yegoraw, Awol M. Assen, Priscilla F. Gerber and Stephen W. Walkden-Brown
    Citation: Veterinary Research 2021 52:91
  34. Lawsonia intracellularis is endemic to swine herds worldwide, however much is still unknown regarding its impact on intestinal function. Thus, this study aimed to characterize the impact of L. intracellularis on ...

    Authors: Emma T. Helm, Eric R. Burrough, Fernando L. Leite and Nicholas K. Gabler
    Citation: Veterinary Research 2021 52:90
  35. Due to increased anthelmintic resistance, complementary methods to drugs are necessary to control gastrointestinal nematodes (GIN). Vaccines are an environmentally-friendly and promising option. In a previous ...

    Authors: Cynthia Machín, Yolanda Corripio-Miyar, Julia N. Hernández, Tara Pérez-Hernández, Adam D. Hayward, Harry W. Wright, Daniel R. G. Price, Jacqueline B. Matthews, Tom N. McNeilly, Alasdair J. Nisbet and Jorge F. González
    Citation: Veterinary Research 2021 52:89
  36. Toll-like receptor 19 (Tlr19) is a fish-specific TLR that plays a critical role in innate immunity. In the present study, we aimed to identify tlr19 from common carp (Cyprinus carpio L.) and explored its expressi...

    Authors: Shijuan Shan, Rongrong Liu, Hanxiao Feng, Fei Meng, Muhanmmad Aizaz and Guiwen Yang
    Citation: Veterinary Research 2021 52:88
  37. The porcine epidemic diarrhea virus (PEDV) causes a highly contagious disease in pigs, which is one of the most devastating viral diseases of swine in the world. In China, PEDV was first confirmed in 1984 and ...

    Authors: Pei-Hua Wang, Ya-Qian Li, Yuan-Qing Pan, Yan-Yan Guo, Fan Guo, Rui-Zhu Shi and Li Xing
    Citation: Veterinary Research 2021 52:87
  38. Porcine deltacoronavirus (PDCoV) is a newly discovered swine enteropathogenic coronavirus with worldwide distribution. However, efficient strategies to prevent or treat the infection remain elusive. Our in vit...

    Authors: Cong Duan, Junchi Wang, Yi Liu, Jialu Zhang, Jianyong Si, Zhihui Hao and Jiufeng Wang
    Citation: Veterinary Research 2021 52:86
  39. Trichinellosis, which is caused by nematodes of the genus Trichinella, is one of the most important zoonotic parasite diseases in the world. A rapid and sensitive immunochromatographic strip (ICS) based on Eu (II...

    Authors: Xinyu Wang, Bin Tang, Ying Zhao, Jing Ding, Nan Wang, Yan Liu, Zijian Dong, Xiangdong Sun, Quangang Xu, Mingyuan Liu and Xiaolei Liu
    Citation: Veterinary Research 2021 52:85
  40. Lamb survival is an important welfare and productivity issue for sheep industries worldwide. Lower lamb survival has been reported for primiparous ewes, but the causes of this are not well studied. The aim of ...

    Authors: Tom Clune, Shane Besier, Sam Hair, Serina Hancock, Amy Lockwood, Andrew Thompson, Martina Jelocnik and Caroline Jacobson
    Citation: Veterinary Research 2021 52:84
  41. Mannheimia haemolytica-induced bovine respiratory disease causes loss of millions of dollars to Canadian cattle industry. Current antimicrobials are proving to be ineffective and leave residues in meat. Antimicro...

    Authors: Harpreet Dhingra, Kamaljit Kaur and Baljit Singh
    Citation: Veterinary Research 2021 52:83
  42. Toxoplasma gondii is an important zoonotic agent with high genetic diversity, complex epidemiology, and variable clinical outcomes in animals and humans. In veterinary medicine, this apicomplexan parasite is cons...

    Authors: Mercedes Fernández-Escobar, Rafael Calero-Bernal, Javier Regidor-Cerrillo, Raquel Vallejo, Julio Benavides, Esther Collantes-Fernández and Luis Miguel Ortega-Mora
    Citation: Veterinary Research 2021 52:82
  43. This study was conducted to investigate the impacts of graded severity of Eimeria maxima infection on the growth performance and intestine health of broiler chickens. Four different levels of E. maxima-challenged...

    Authors: Po-Yun Teng, Janghan Choi, Yuguo Tompkins, Hyun Lillehoj and Woo Kim
    Citation: Veterinary Research 2021 52:81
  44. Mycoplasma hyorhinis infects pigs causing polyserositis and polyarthritis, and has also been reported in a variety of human tumor tissues. The occurrence of disease is often linked with the systemic invasion of t...

    Authors: Jia Wang, Yao Li, Longji Pan, Jun Li, Yanfei Yu, Beibei Liu, Muhammad Zubair, Yanna Wei, Bala Pillay, Ademola Olufolahan Olaniran, Thamsanqa E. Chiliza, Guoqing Shao, Zhixin Feng and Qiyan Xiong
    Citation: Veterinary Research 2021 52:80
  45. Aptamers are small nucleic acids that fold in a three-dimensional conformation allowing them to bind specifically to a target. This target can be an organic molecule, free or carried in cells or tissues, or in...

    Authors: Solène Niederlender, Jean-Jacques Fontaine and Grégory Karadjian
    Citation: Veterinary Research 2021 52:79
  46. In vivo study of tissue or organ biology in mammals is very complex and progress is slowed by poor accessibility of samples and ethical concerns. Fortunately, however, advances in stem cell identification and ...

    Authors: Laurence Finot, Eric Chanat and Frederic Dessauge
    Citation: Veterinary Research 2021 52:78
  47. The number and severity of diseases affecting lung development and adult respiratory function have stimulated great interest in developing new in vitro models to study lung in different species. Recent breakth...

    Authors: Fabienne Archer, Alexandra Bobet-Erny and Maryline Gomes
    Citation: Veterinary Research 2021 52:77
  48. Brucella spp. are Gram-negative, facultative intracellular bacteria that cause brucellosis in humans and various animals. The threat of brucellosis has increased, yet currently available live attenuated vaccines ...

    Authors: Xiaodong Zai, Ying Yin, Fengyu Guo, Qiaoling Yang, Ruihua Li, Yaohui Li, Jun Zhang, Junjie Xu and Wei Chen
    Citation: Veterinary Research 2021 52:75

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