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  1. Cell-mediated immune responses to Mycobacterium avium subsp. paratuberculosis (MAP) are regulated by various types of T lymphocytes. The aim of this study was to quantitate T cell subsets in the mid-ileum of cows...

    Authors: Caitlin J. Jenvey, Adrienne L. Shircliff, Elsa Obando Marrero and Judith R. Stabel

    Citation: Veterinary Research 2021 52:55

    Content type: Research article

    Published on:

  2. Trypanosoma cruzi is a zoonotic parasite endemic in the southern US and the Americas, which may frequently infect dogs, but limited information is available about infections in cats. We surveyed a convenience sam...

    Authors: Eric Dumonteil, Hans Desale, Weihong Tu, Brandy Duhon, Wendy Wolfson, Gary Balsamo and Claudia Herrera

    Citation: Veterinary Research 2021 52:53

    Content type: Research article

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  3. Long non-coding RNAs (lncRNAs) are a new arm of gene regulatory mechanism as discovered by sequencing techniques and follow-up functional studies. The lncRNAs regulation of pseudorabies virus (PRV) infection h...

    Authors: Linlin Fang, Yanni Gao, Xing Liu, Juan Bai, Ping Jiang and XianWei Wang

    Citation: Veterinary Research 2021 52:52

    Content type: Research article

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  4. Trichinella spiralis is an important foodborne parasitic nematode distributed worldwide that infects humans and animals. Glutaminase (GLS) is an important gene in the glutamine-dependent acid resistance (AR) syst...

    Authors: Yuan Gao, Xiaoqing Meng, Xiao Yang, Shi Meng, Caixia Han, Xiaoyun Li, Shuang Wang, Wei Li and Mingxin Song

    Citation: Veterinary Research 2021 52:51

    Content type: Research article

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  5. Streptococcus suis (S. suis) is an important zoonotic pathogen that causes septicaemia, meningitis and streptococcal toxic shock-like syndrome in its host, and recent studies have shown that S. suis could be comp...

    Authors: Yinchu Zhu, Jiale Ma, Yue Zhang, Xiaojun Zhong, Qiankun Bai, Wenyang Dong, Zihao Pan, Guangjin Liu, Cun Zhang and Huochun Yao

    Citation: Veterinary Research 2021 52:50

    Content type: Research article

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  6. Streptococcus suis is one of the most important bacterial swine pathogens affecting post-weaned piglets, causing mainly meningitis, arthritis and sudden death. It not only results in severe economic losses but al...

    Authors: Milan R. Obradovic, Mariela Segura, Joaquim Segalés and Marcelo Gottschalk

    Citation: Veterinary Research 2021 52:49

    Content type: Review

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  7. Iron is essential for most bacteria to survive, but excessive iron leads to damage by the Fenton reaction. Therefore, the concentration of intracellular free iron must be strictly controlled in bacteria. Riemerel...

    Authors: Mi Huang, Mafeng Liu, Jiajun Liu, Dekang Zhu, Qianying Tang, Renyong Jia, Shun Chen, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Xumin Ou, Sai Mao, Qun Gao, Di Sun…

    Citation: Veterinary Research 2021 52:48

    Content type: Research article

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  8. Mycobacterium avium subsp. paratuberculosis (MAP) is a causative agent of Johne’s disease, which is a chronic granulomatous enteropathy in ruminants. Determining the genetic diversity of MAP is necessary to under...

    Authors: Jaewon Lim, Hong-Tae Park, Seyoung Ko, Hyun-Eui Park, Gyumin Lee, Suji Kim, Min-Kyoung Shin, Han Sang Yoo and Donghyuk Kim

    Citation: Veterinary Research 2021 52:46

    Content type: Research article

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  9. Neutralizing antibodies (NAbs) have attracted attention as tools for achieving PRRSV control and prevention, but viral antigenic variation undermines the abilities of NAbs elicited by attenuated PRRSV vaccines...

    Authors: Zhigang Zhang, Tianshu Zhai, Mingshuo Li, Kun Zhang, Jingrui Li, Xu Zheng, Chaonan Tian, Rui Chen, Jianhui Dong, En-Min Zhou, Yuchen Nan and Chunyan Wu

    Citation: Veterinary Research 2021 52:45

    Content type: Research article

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  10. Small non-coding RNA RyhB is a key regulator of iron homeostasis in bacteria by sensing iron availability in the environment. Although RyhB is known to influence bacterial virulence by interacting with iron me...

    Authors: Binjie Chen, Xianchen Meng, Jie Ni, Mengping He, Yanfei Chen, Pengpeng Xia, Heng Wang, Siguo Liu, Guoqiang Zhu and Xia Meng

    Citation: Veterinary Research 2021 52:44

    Content type: Research article

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  11. Organoids are self-organizing, self-renewing three-dimensional cellular structures that resemble organs in structure and function. They can be derived from adult stem cells, embryonic stem cells, or induced pl...

    Authors: Soumya K. Kar, Jerry M. Wells, Esther D. Ellen, Marinus F. W. te Pas, Ole Madsen, Martien A. M. Groenen and Henri Woelders

    Citation: Veterinary Research 2021 52:43

    Content type: Review

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  12. Within the past decades, major progress has been accomplished in isolating germ/stem/pluripotent cells, in refining culture medium and conditions and in establishing 3-dimensional culture systems, towards deve...

    Authors: Guillaume Bourdon, Véronique Cadoret, Gilles Charpigny, Anne Couturier-Tarrade, Rozenn Dalbies-Tran, Maria-José Flores, Pascal Froment, Mariam Raliou, Karine Reynaud, Marie Saint-Dizier and Alice Jouneau

    Citation: Veterinary Research 2021 52:42

    Content type: Review

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  13. MicroRNAs (miRNAs) are short, non-coding RNAs, 21–23 nucleotides in length which are known to regulate biological processes that greatly impact immune system activity. The aim of the study was to compare the m...

    Authors: Emilia Bagnicka, Ewelina Kawecka-Grochocka, Klaudia Pawlina-Tyszko, Magdalena Zalewska, Aleksandra Kapusta, Ewa Kościuczuk, Sylwester Marczak and Tomasz Ząbek

    Citation: Veterinary Research 2021 52:41

    Content type: Research article

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  14. Leveraging artificial intelligence (AI) approaches in animal health (AH) makes it possible to address highly complex issues such as those encountered in quantitative and predictive epidemiology, animal/human p...

    Authors: Pauline Ezanno, Sébastien Picault, Gaël Beaunée, Xavier Bailly, Facundo Muñoz, Raphaël Duboz, Hervé Monod and Jean-François Guégan

    Citation: Veterinary Research 2021 52:40

    Content type: Review

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  15. Zinc (Zn) is an essential trace element in living organisms and plays a vital role in the regulation of both microbial virulence and host immune responses. A growing number of studies have shown that zinc defi...

    Authors: Pengpeng Xia, Siqi Lian, Yunping Wu, Li Yan, Guomei Quan and Guoqiang Zhu

    Citation: Veterinary Research 2021 52:39

    Content type: Review

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  16. Organoids are three-dimensional structures that are derived from the self-organization of stem cells as they differentiate in vitro. The plasticity of stem cells is one of the major criteria for generating org...

    Authors: Bertrand Pain

    Citation: Veterinary Research 2021 52:38

    Content type: Review

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  17. Fowl cholera caused by Pasteurella multocida exerts a massive economic burden on the poultry industry. Lipopolysaccharide (LPS) is essential for the growth of P. multocida genotype L1 strains in chickens and spec...

    Authors: Xinxin Zhao, Hui Shen, Sheng Liang, Dekang Zhu, Mingshu Wang, Renyong Jia, Shun Chen, Mafeng Liu, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Xumin Ou, Sai Mao, Qun Gao, Ling Zhang…

    Citation: Veterinary Research 2021 52:37

    Content type: Research article

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  18. Exosomes are membrane vesicles containing proteins, lipids, DNA, mRNA, and micro RNA (miRNA). Exosomal miRNA from donor cells can regulate the gene expression of recipient cells. Here, Ri chickens were divided...

    Authors: Yeojin Hong, Anh Duc Truong, Jiae Lee, Thi Hao Vu, Sooyeon Lee, Ki-Duk Song, Hyun S. Lillehoj and Yeong Ho Hong

    Citation: Veterinary Research 2021 52:36

    Content type: Research article

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  19. Recently, the outbreaks of hydropericardium-hepatitis syndrome (HHS) caused by the highly pathogenic fowl adenovirus serotype 4 (FAdV-4) have resulted in huge economic losses to the poultry industry globally. ...

    Authors: Quan Xie, Shiya Cao, Wei Zhang, Weikang Wang, Luyuan Li, Qiuqi Kan, Hui Fu, Tuoyu Geng, Tuofan Li, Zhimin Wan, Wei Gao, Hongxia Shao, Aijian Qin and Jianqiang Ye

    Citation: Veterinary Research 2021 52:35

    Content type: Research article

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  20. Staphylococcus delphini is one of the most common pathogens isolated from mink infections, especially dermatitis. Tylosin (TYL) is used frequently against these infections, although no evidence-based treatment re...

    Authors: Amir Atabak Ronaghinia, Julie Melsted Birch, Henrik Lauritz Frandsen, Pierre-Louis Toutain, Peter Damborg and Tina Struve

    Citation: Veterinary Research 2021 52:34

    Content type: Research article

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  21. In livestock species, the monolayer of epithelial cells covering the digestive mucosa plays an essential role for nutrition and gut barrier function. However, research on farm animal intestinal epithelium has ...

    Authors: Martin Beaumont, Fany Blanc, Claire Cherbuy, Giorgia Egidy, Elisabetta Giuffra, Sonia Lacroix-Lamandé and Agnès Wiedemann

    Citation: Veterinary Research 2021 52:33

    Content type: Review

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  22. Tissue factor pathway inhibitors (TFPI), including TFPI-1 and TFPI-2, are Kunitz-type serine protease inhibitors that mainly inhibit the blood coagulation induced by tissue factors. Previous reports on teleost...

    Authors: Guanghua Wang, Bing Xie, Yanli Su, Qinqin Gu, Dongfang Hao, Hongmei Liu, Changbiao Wang, Yonghua Hu and Min Zhang

    Citation: Veterinary Research 2021 52:32

    Content type: Research article

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  23. Animal tuberculosis (TB) is a multi-host disease caused by members of the Mycobacterium tuberculosis complex (MTC). Due to its impact on economy, sanitary standards of milk and meat industry, public health and co...

    Authors: Jobin Thomas, Ana Balseiro, Christian Gortázar and María A. Risalde

    Citation: Veterinary Research 2021 52:31

    Content type: Review

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  24. Host proteins interacting with pathogens are receiving more attention as potential therapeutic targets in molecular medicine. Streptococcus suis serotype 2 (SS2) is an important cause of meningitis in both humans...

    Authors: Hongtao Liu, Siyu Lei, Li Jia, Xiaojing Xia, Yingying Sun, Hexiang Jiang, Rining Zhu, Shuguang Li, Guanggang Qu, Jingmin Gu, Changjiang Sun, Xin Feng, Wenyu Han, Paul R. Langford and Liancheng Lei

    Citation: Veterinary Research 2021 52:30

    Content type: Research article

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  25. Rhomboid-like proteases (ROMs) are considered as new candidate antigens for developing new-generation vaccines due to their important role involved in the invasion of apicomplexan protozoa. In prior works, we ...

    Authors: Yufeng Chen, Di Tian, Lixin Xu, Ruofeng Yan, Xiangrui Li, Muhammad Ali A. Shah and Xiaokai Song

    Citation: Veterinary Research 2021 52:29

    Content type: Research article

    Published on:

  26. CD9 is a glycoprotein of the transmembrane 4 superfamily that is involved in various cellular processes. Studies related to the immune functions and activities of CD9 in teleost fish are limited. In this study...

    Authors: Jiaojiao He, Hanjie Gu, Wenqi Wang and Yonghua Hu

    Citation: Veterinary Research 2021 52:28

    Content type: Research article

    Published on:

  27. Gallibacterium anatis is a common cause of reproductive tract infection in chickens, which leads to reduced egg production and increased mortality. This study was undertaken to investigate prevalence of G. anatis

    Authors: Toloe Allahghadry, Duncan Y. K. Ng, Alireza Dibaei and Anders Miki Bojesen

    Citation: Veterinary Research 2021 52:27

    Content type: Research article

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  28. Porcine epidemic diarrhea virus (PEDV) primarily infects neonatal piglets causing catastrophic effects on the global pig farming industry. PEDV infects piglets through the nasal cavity, a process in which dend...

    Authors: Chen Yuan, Yuxin Jin, Yuchen Li, En Zhang, Penghao Zhang and Qian Yang

    Citation: Veterinary Research 2021 52:26

    Content type: Research article

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  29. Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly contagious virus that has led to enormous economic loss worldwide because of ineffective prevention and treatment. In view of their minim...

    Authors: Lu Zhang, Lizhen Wang, Shuaishuai Cao, Huanhuan Lv, Jingjing Huang, Guixi Zhang, Kaissar Tabynov, Qin Zhao and En-Min Zhou

    Citation: Veterinary Research 2021 52:25

    Content type: Research article

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  30. Avian coccidiosis caused by Eimeria leads to huge economic losses on the global poultry industry. In this study, microneme adhesive repeat regions (MARR) bc1 of E. tenella microneme protein 3 (EtMIC3-bc1) was use...

    Authors: Wenjing Chen, Chunli Ma, Guanghao Li, Zhipeng Jia, Xuelian Yang, Xinghui Pan and Dexing Ma

    Citation: Veterinary Research 2021 52:24

    Content type: Research article

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  31. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xiu Li Feng, Yang Zheng, Man Man Zong, Shan Shan Hao, Guang Fang Zhou, Rui Bing Cao, Pu Yan Chen and Qing Tao Liu

    Citation: Veterinary Research 2021 52:23

    Content type: Correction

    Published on:

    The original article was published in Veterinary Research 2019 50:64

  32. COVID-19 is a zoonotic disease caused by SARS-CoV-2. Infections of animals with SARS-CoV-2 have recently been reported, and an increase of severe lung pathologies in domestic dogs has also been detected by vet...

    Authors: Ana Judith Perisé-Barrios, Beatriz Davinia Tomeo-Martín, Pablo Gómez-Ochoa, Pablo Delgado-Bonet, Pedro Plaza, Paula Palau-Concejo, Jorge González, Gustavo Ortiz-Díez, Antonio Meléndez-Lazo, Michaela Gentil, Javier García-Castro and Alicia Barbero-Fernández

    Citation: Veterinary Research 2021 52:22

    Content type: Research article

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  33. The skin is a passive and active barrier which protects the body from the environment. Its health is essential for the accomplishment of this role. Since several decades, the skin has aroused a strong interest...

    Authors: Laurent Souci and Caroline Denesvre

    Citation: Veterinary Research 2021 52:21

    Content type: Review

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  34. Processing and packaging of herpesvirus genomic DNA is regulated by a packaging-associated terminase complex comprising of viral proteins pUL15, pUL28 and pUL33. Marek’s disease virus (MDV) homologs UL28 and U...

    Authors: Aijun Sun, Shuaikang Yang, Jun Luo, Man Teng, Yijie Xu, Rui Wang, Xiaojing Zhu, Luping Zheng, Yanan Wu, Yongxiu Yao, Venugopal Nair, Gaiping Zhang and Guoqing Zhuang

    Citation: Veterinary Research 2021 52:20

    Content type: Research article

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  35. Riemerella anatipestifer causes epizootic infectious disease in poultry resulting in serious economic losses especially to the duck industry. In our previous study, R. anatipestifer was found to lyse duck erythro...

    Authors: Bingqing Sun, Yafei Xue, Xiaoli Du, Xiaohua He, Zuocheng Zou, Xiangqiang Tian, Zhonghao Hu, Haoyang Liu, Nazrul Islam and Qinghai Hu

    Citation: Veterinary Research 2021 52:19

    Content type: Research article

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  36. This study reports the comparative analyses of four Flavobacterium columnare isolates that have different virulence and antimicrobial resistance patterns. The main research goal was to reveal new insights into po...

    Authors: Annelies Maria Declercq, Laurentijn Tilleman, Yannick Gansemans, Chloë De Witte, Freddy Haesebrouck, Filip Van Nieuwerburgh, Annemieke Smet and Annemie Decostere

    Citation: Veterinary Research 2021 52:18

    Content type: Research article

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  37. Klebsiella pneumoniae, an important cause of bovine mastitis worldwide, is strongly pathogenic to bovine mammary epithelial cells (bMECs). Our objective was to determine the role of mitochondrial damage in the pa...

    Authors: Jia Cheng, Jv Zhang, Jingyue Yang, Bing Yi, Gang Liu, Man Zhou, John P. Kastelic, Bo Han and Jian Gao

    Citation: Veterinary Research 2021 52:17

    Content type: Research article

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  38. Klebsiella (K.) pneumoniae as a multi-drug resistant (MDR) pathogen is an emerging challenge for clinicians worldwide. Virulence factors are capsular antigens, adherence factors, the O-lipopolysaccharide, and sid...

    Authors: Gamal Wareth and Heinrich Neubauer

    Citation: Veterinary Research 2021 52:16

    Content type: Review

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  39. Avian coccidiosis caused by Eimeria leads to severe economic losses in the global poultry industry. Although chicken Toll-like receptor 15 (ChTLR15) was reported to be involved in Eimeria infection, the detailed ...

    Authors: Jian Li, Xuelian Yang, Zhipeng Jia, Chunli Ma, Xinghui Pan and Dexing Ma

    Citation: Veterinary Research 2021 52:15

    Content type: Research article

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  40. Infectious bronchitis virus (IBV) is a pathogenic coronavirus with high morbidity and mortality in chicken breeding. Macrophages with normal biofunctions are essential for host immune responses. In this study,...

    Authors: Xiaoqi Sun, Zheng Wang, Changhao Shao, Jia Yu, Haoyun Liu, Huijie Chen, Lu Li, Xiurong Wang, Yudong Ren, Xiaodan Huang, Ruili Zhang and Guangxing Li

    Citation: Veterinary Research 2021 52:14

    Content type: Research article

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  41. In this work we report the protection found in a vaccination trial performed in sheep with two different vaccines composed each one by a cocktail of antigens (rCL1, rPrx, rHDM and rLAP) formulated in two diffe...

    Authors: Rafael Zafra, Leandro Buffoni, Raúl Pérez-Caballero, Verónica Molina-Hernández, María T. Ruiz-Campillo, José Pérez, Álvaro Martínez-Moreno and Francisco J. Martínez Moreno

    Citation: Veterinary Research 2021 52:13

    Content type: Research article

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  42. PRRSV-1 virulent strains cause high fever, marked respiratory disease and severe lesions in lung and lymphoid organs. Regulated cell death (RCD), such as apoptosis, necroptosis and pyroptosis, is triggered by ...

    Authors: Jose María Sánchez-Carvajal, Inés Ruedas-Torres, Librado Carrasco, Francisco José Pallarés, Enric Mateu, Irene Magdalena Rodríguez-Gómez and Jaime Gómez-Laguna

    Citation: Veterinary Research 2021 52:12

    Content type: Research article

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  43. Infection with Mycobacterium avium subspecies paratuberculosis (MAP) is complex, but little is known about the role that natural killer (NK) cells play. In the present study, four bovine NK-lysin peptides were sy...

    Authors: Rohana P. Dassanayake, Taylor L. T. Wherry, Shollie M. Falkenberg, Timothy A. Reinhardt, Eduardo Casas and Judith R. Stabel

    Citation: Veterinary Research 2021 52:11

    Content type: Short report

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  44. Serotyping is the most common method to characterize field isolates of Actinobacillus (A.) pleuropneumoniae, the etiological agent of porcine pleuropneumonia. Based on serology, many farms seem to be infected and...

    Authors: Lukas Schuwerk, Doris Hoeltig, Karl-Heinz Waldmann, Peter Valentin-Weigand and Judith Rohde

    Citation: Veterinary Research 2021 52:10

    Content type: Research article

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  45. Novel duck reovirus (NDRV) causes severe economic losses to the duck industry, which is characterized by hemorrhagic spots and necrotic foci of the livers and spleens. DEAD-box helicase 1 (DDX1) plays a critic...

    Authors: Huihui Zhang, Xingdong Song, Tianxu Li, Jinchao Wang, Bin Xing, Xinyu Zhai, Jinjian Luo, Xiaofang Hu, Xiaolan Hou and Liangmeng Wei

    Citation: Veterinary Research 2021 52:9

    Content type: Research article

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  46. Since 2014, clade 2.3.4.4 has become the dominant epidemic branch of the Asian lineage H5 subtype highly pathogenic avian influenza virus (HPAIV) in southern and eastern China, while the H5N6 subtype is the mo...

    Authors: Ruyi Gao, Min Gu, Liwei Shi, Kaituo Liu, Xiuli Li, Xiaoquan Wang, Jiao Hu, Xiaowen Liu, Shunlin Hu, Sujuan Chen, Daxin Peng, Xinan Jiao and Xiufan Liu

    Citation: Veterinary Research 2021 52:8

    Content type: Research article

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  47. Elucidating virus-cell interactions is fundamental to understanding viral replication and identifying targets for therapeutic control of viral infection. The extracellular signal-regulated kinase (ERK) pathway...

    Authors: Huan Wang, Dingxiang Liu, Yingjie Sun, Chunchun Meng, Lei Tan, Cuiping Song, Xusheng Qiu, Weiwei Liu, Chan Ding and Liao Ying

    Citation: Veterinary Research 2021 52:7

    Content type: Research article

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  48. Bovine respiratory diseases (BRD) are a major concern for the beef cattle industry, as beef calves overwhelmingly develop BRD symptoms during the first weeks after their arrival at fattening units. These cases...

    Authors: Thibaut Morel-Journel, Sébastien Assié, Elisabeta Vergu, Jean-Baptiste Mercier, Florence Bonnet-Beaugrand and Pauline Ezanno

    Citation: Veterinary Research 2021 52:5

    Content type: Research article

    Published on:

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