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  1. Paratuberculosis is a disease of ruminants caused by Mycobacterium avium subsp. paratuberculosis (Map). Vaccination is the most cost-effective control method. However, despite the fact that macrophages are the ma...

    Authors: Noive Arteche-Villasol, Daniel Gutiérrez-Expósito, Raquel Vallejo, Jose Espinosa, Natalia Elguezabal, Iraia Ladero-Auñon, Marcos Royo, María del Carmen Ferreras, Julio Benavides and Valentín Pérez
    Citation: Veterinary Research 2021 52:69
  2. Mycoplasma hyopneumoniae (M. hyopneumoniae) is one of the primary agents involved in the porcine respiratory disease complex, economically one of the most important diseases in pigs worldwide. The pathogen adhere...

    Authors: Dominiek Maes, Filip Boyen, Bert Devriendt, Peter Kuhnert, Artur Summerfield and Freddy Haesebrouck
    Citation: Veterinary Research 2021 52:67
  3. Cystic echinococcosis is a zoonotic disease caused by the metacestode of Echinococcus granulosus sensu lato. The disease is characterized by the development of cystic structures inside viscera of the intermediate...

    Authors: Christian Hidalgo, Caroll Stoore, María Soledad Baquedano, Ismael Pereira, Carmen Franco, Marcela Hernández and Rodolfo Paredes
    Citation: Veterinary Research 2021 52:66
  4. Salmonid Rickettsial Septicaemia (SRS), caused by Piscirickettsia salmonis, is the most important infectious disease in the Chilean salmon farming industry. An opportunity to control this disease is to use functi...

    Authors: Javiera Pérez-Valenzuela, Madelaine Mejías, Daniela Ortiz, Pablo Salgado, Liliana Montt, Ignacio Chávez-Báez, Francisca Vera-Tamargo, Dinka Mandakovic, Jurij Wacyk and Rodrigo Pulgar
    Citation: Veterinary Research 2021 52:64
  5. The TonB system is generally considered as an energy transporting device for the absorption of nutrients. Our recent study showed that deletion of this system caused a significantly increased sensitivity of Aerom...

    Authors: Yuhao Dong, Qing Li, Jinzhu Geng, Qing Cao, Dan Zhao, Mingguo Jiang, Shougang Li, Chengping Lu and Yongjie Liu
    Citation: Veterinary Research 2021 52:63
  6. Communications via quorum sensing (QS) between non-aureus staphylococci (NAS) and Staphylococcus (S.) aureus in the bovine mammary gland remains largely unexplored. We determined whether 34 S. chromogenes, 11 S. ...

    Authors: Bruno Toledo-Silva, Fernando Nogueira de Souza, Sofie Piepers, Kristien Mertens, Freddy Haesebrouck and Sarne De Vliegher
    Citation: Veterinary Research 2021 52:62
  7. Infectious bursal disease virus (IBDV) and fowl adenovirus serotype 4 (FAdV-4) cause infectious bursal disease (IBD) and hydropericardium-hepatitis syndrome, respectively. Recently, studies have reported co-in...

    Authors: A-hui Xu, Lu Sun, Kai-hang Tu, Qing-yuan Teng, Jia Xue and Guo-zhong Zhang
    Citation: Veterinary Research 2021 52:61
  8. Influenza A viruses (IAVs) are common causes of respiratory infection in pigs. The objective of this study was to characterize the circulation of IAVs between weaning and market age on the basis of development...

    Authors: Juliana Bonin Ferreira, Zvonimir Poljak, Robert Friendship, Éva Nagy, Greg Wideman and Helena Grgić
    Citation: Veterinary Research 2021 52:60
  9. The unconventional infectious agents of transmissible spongiform encephalopathies (TSEs) are prions. Their infectivity co-appears with PrPSc, aberrant depositions of the host’s cellular prion protein (PrPC). Succ...

    Authors: Jan P. M. Langeveld, Anne Balkema-Buschmann, Dieter Becher, Achim Thomzig, Romolo Nonno, Olivier Andréoletti, Aart Davidse, Michele A. Di Bari, Laura Pirisinu, Umberto Agrimi, Martin H. Groschup, Michael Beekes and Jason Shih
    Citation: Veterinary Research 2021 52:59
  10. Mycoplasma bovis (M. bovis) is a significant worldwide pathogen of cattle. Neutrophils have an important role in the innate immune response during infection with M. bovis. However, even though neutrophils accumul...

    Authors: Satoshi Gondaira, Koji Nishi, Jumpei Fujiki, Hidetomo Iwano, Reina Watanabe, Ayako Eguchi, Yuki Hirano, Hidetoshi Higuchi and Hajime Nagahata
    Citation: Veterinary Research 2021 52:58
  11. The diversity of goat scrapie strains in Europe has recently been studied using bioassays in a wide collection of rodent models, resulting in the classification of classical scrapie into four different categor...

    Authors: Alba Marín-Moreno, Patricia Aguilar-Calvo, Juan Carlos Espinosa, María Zamora-Ceballos, José Luis Pitarch, Lorenzo González, Natalia Fernández-Borges, Leonor Orge, Olivier Andréoletti, Romolo Nonno and Juan María Torres
    Citation: Veterinary Research 2021 52:57
  12. ELISA methods are the diagnostic tools recommended for the serological diagnosis of Coxiella burnetii infection in ruminants but their respective diagnostic performances are difficult to assess because of the abs...

    Authors: Thibaut Lurier, Elodie Rousset, Patrick Gasqui, Carole Sala, Clément Claustre, David Abrial, Philippe Dufour, Renée de Crémoux, Kristel Gache, Marie Laure Delignette-Muller, Florence Ayral and Elsa Jourdain
    Citation: Veterinary Research 2021 52:56
  13. Cell-mediated immune responses to Mycobacterium avium subsp. paratuberculosis (MAP) are regulated by various types of T lymphocytes. The aim of this study was to quantitate T cell subsets in the mid-ileum of cows...

    Authors: Caitlin J. Jenvey, Adrienne L. Shircliff, Elsa Obando Marrero and Judith R. Stabel
    Citation: Veterinary Research 2021 52:55
  14. Trypanosoma cruzi is a zoonotic parasite endemic in the southern US and the Americas, which may frequently infect dogs, but limited information is available about infections in cats. We surveyed a convenience sam...

    Authors: Eric Dumonteil, Hans Desale, Weihong Tu, Brandy Duhon, Wendy Wolfson, Gary Balsamo and Claudia Herrera
    Citation: Veterinary Research 2021 52:53
  15. Long non-coding RNAs (lncRNAs) are a new arm of gene regulatory mechanism as discovered by sequencing techniques and follow-up functional studies. The lncRNAs regulation of pseudorabies virus (PRV) infection h...

    Authors: Linlin Fang, Yanni Gao, Xing Liu, Juan Bai, Ping Jiang and XianWei Wang
    Citation: Veterinary Research 2021 52:52
  16. Trichinella spiralis is an important foodborne parasitic nematode distributed worldwide that infects humans and animals. Glutaminase (GLS) is an important gene in the glutamine-dependent acid resistance (AR) syst...

    Authors: Yuan Gao, Xiaoqing Meng, Xiao Yang, Shi Meng, Caixia Han, Xiaoyun Li, Shuang Wang, Wei Li and Mingxin Song
    Citation: Veterinary Research 2021 52:51
  17. Streptococcus suis (S. suis) is an important zoonotic pathogen that causes septicaemia, meningitis and streptococcal toxic shock-like syndrome in its host, and recent studies have shown that S. suis could be comp...

    Authors: Yinchu Zhu, Jiale Ma, Yue Zhang, Xiaojun Zhong, Qiankun Bai, Wenyang Dong, Zihao Pan, Guangjin Liu, Cun Zhang and Huochun Yao
    Citation: Veterinary Research 2021 52:50
  18. Streptococcus suis is one of the most important bacterial swine pathogens affecting post-weaned piglets, causing mainly meningitis, arthritis and sudden death. It not only results in severe economic losses but al...

    Authors: Milan R. Obradovic, Mariela Segura, Joaquim Segalés and Marcelo Gottschalk
    Citation: Veterinary Research 2021 52:49
  19. Iron is essential for most bacteria to survive, but excessive iron leads to damage by the Fenton reaction. Therefore, the concentration of intracellular free iron must be strictly controlled in bacteria. Riemerel...

    Authors: Mi Huang, Mafeng Liu, Jiajun Liu, Dekang Zhu, Qianying Tang, Renyong Jia, Shun Chen, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Xumin Ou, Sai Mao, Qun Gao, Di Sun…
    Citation: Veterinary Research 2021 52:48
  20. Mycobacterium avium subsp. paratuberculosis (MAP) is a causative agent of Johne’s disease, which is a chronic granulomatous enteropathy in ruminants. Determining the genetic diversity of MAP is necessary to under...

    Authors: Jaewon Lim, Hong-Tae Park, Seyoung Ko, Hyun-Eui Park, Gyumin Lee, Suji Kim, Min-Kyoung Shin, Han Sang Yoo and Donghyuk Kim
    Citation: Veterinary Research 2021 52:46
  21. Neutralizing antibodies (NAbs) have attracted attention as tools for achieving PRRSV control and prevention, but viral antigenic variation undermines the abilities of NAbs elicited by attenuated PRRSV vaccines...

    Authors: Zhigang Zhang, Tianshu Zhai, Mingshuo Li, Kun Zhang, Jingrui Li, Xu Zheng, Chaonan Tian, Rui Chen, Jianhui Dong, En-Min Zhou, Yuchen Nan and Chunyan Wu
    Citation: Veterinary Research 2021 52:45
  22. Small non-coding RNA RyhB is a key regulator of iron homeostasis in bacteria by sensing iron availability in the environment. Although RyhB is known to influence bacterial virulence by interacting with iron me...

    Authors: Binjie Chen, Xianchen Meng, Jie Ni, Mengping He, Yanfei Chen, Pengpeng Xia, Heng Wang, Siguo Liu, Guoqiang Zhu and Xia Meng
    Citation: Veterinary Research 2021 52:44
  23. Organoids are self-organizing, self-renewing three-dimensional cellular structures that resemble organs in structure and function. They can be derived from adult stem cells, embryonic stem cells, or induced pl...

    Authors: Soumya K. Kar, Jerry M. Wells, Esther D. Ellen, Marinus F. W. te Pas, Ole Madsen, Martien A. M. Groenen and Henri Woelders
    Citation: Veterinary Research 2021 52:43
  24. Within the past decades, major progress has been accomplished in isolating germ/stem/pluripotent cells, in refining culture medium and conditions and in establishing 3-dimensional culture systems, towards deve...

    Authors: Guillaume Bourdon, Véronique Cadoret, Gilles Charpigny, Anne Couturier-Tarrade, Rozenn Dalbies-Tran, Maria-José Flores, Pascal Froment, Mariam Raliou, Karine Reynaud, Marie Saint-Dizier and Alice Jouneau
    Citation: Veterinary Research 2021 52:42
  25. MicroRNAs (miRNAs) are short, non-coding RNAs, 21–23 nucleotides in length which are known to regulate biological processes that greatly impact immune system activity. The aim of the study was to compare the m...

    Authors: Emilia Bagnicka, Ewelina Kawecka-Grochocka, Klaudia Pawlina-Tyszko, Magdalena Zalewska, Aleksandra Kapusta, Ewa Kościuczuk, Sylwester Marczak and Tomasz Ząbek
    Citation: Veterinary Research 2021 52:41
  26. Leveraging artificial intelligence (AI) approaches in animal health (AH) makes it possible to address highly complex issues such as those encountered in quantitative and predictive epidemiology, animal/human p...

    Authors: Pauline Ezanno, Sébastien Picault, Gaël Beaunée, Xavier Bailly, Facundo Muñoz, Raphaël Duboz, Hervé Monod and Jean-François Guégan
    Citation: Veterinary Research 2021 52:40
  27. Zinc (Zn) is an essential trace element in living organisms and plays a vital role in the regulation of both microbial virulence and host immune responses. A growing number of studies have shown that zinc defi...

    Authors: Pengpeng Xia, Siqi Lian, Yunping Wu, Li Yan, Guomei Quan and Guoqiang Zhu
    Citation: Veterinary Research 2021 52:39
  28. Organoids are three-dimensional structures that are derived from the self-organization of stem cells as they differentiate in vitro. The plasticity of stem cells is one of the major criteria for generating org...

    Authors: Bertrand Pain
    Citation: Veterinary Research 2021 52:38
  29. Fowl cholera caused by Pasteurella multocida exerts a massive economic burden on the poultry industry. Lipopolysaccharide (LPS) is essential for the growth of P. multocida genotype L1 strains in chickens and spec...

    Authors: Xinxin Zhao, Hui Shen, Sheng Liang, Dekang Zhu, Mingshu Wang, Renyong Jia, Shun Chen, Mafeng Liu, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Xumin Ou, Sai Mao, Qun Gao, Ling Zhang…
    Citation: Veterinary Research 2021 52:37
  30. Exosomes are membrane vesicles containing proteins, lipids, DNA, mRNA, and micro RNA (miRNA). Exosomal miRNA from donor cells can regulate the gene expression of recipient cells. Here, Ri chickens were divided...

    Authors: Yeojin Hong, Anh Duc Truong, Jiae Lee, Thi Hao Vu, Sooyeon Lee, Ki-Duk Song, Hyun S. Lillehoj and Yeong Ho Hong
    Citation: Veterinary Research 2021 52:36
  31. Recently, the outbreaks of hydropericardium-hepatitis syndrome (HHS) caused by the highly pathogenic fowl adenovirus serotype 4 (FAdV-4) have resulted in huge economic losses to the poultry industry globally. ...

    Authors: Quan Xie, Shiya Cao, Wei Zhang, Weikang Wang, Luyuan Li, Qiuqi Kan, Hui Fu, Tuoyu Geng, Tuofan Li, Zhimin Wan, Wei Gao, Hongxia Shao, Aijian Qin and Jianqiang Ye
    Citation: Veterinary Research 2021 52:35
  32. Staphylococcus delphini is one of the most common pathogens isolated from mink infections, especially dermatitis. Tylosin (TYL) is used frequently against these infections, although no evidence-based treatment re...

    Authors: Amir Atabak Ronaghinia, Julie Melsted Birch, Henrik Lauritz Frandsen, Pierre-Louis Toutain, Peter Damborg and Tina Struve
    Citation: Veterinary Research 2021 52:34
  33. In livestock species, the monolayer of epithelial cells covering the digestive mucosa plays an essential role for nutrition and gut barrier function. However, research on farm animal intestinal epithelium has ...

    Authors: Martin Beaumont, Fany Blanc, Claire Cherbuy, Giorgia Egidy, Elisabetta Giuffra, Sonia Lacroix-Lamandé and Agnès Wiedemann
    Citation: Veterinary Research 2021 52:33
  34. Tissue factor pathway inhibitors (TFPI), including TFPI-1 and TFPI-2, are Kunitz-type serine protease inhibitors that mainly inhibit the blood coagulation induced by tissue factors. Previous reports on teleost...

    Authors: Guanghua Wang, Bing Xie, Yanli Su, Qinqin Gu, Dongfang Hao, Hongmei Liu, Changbiao Wang, Yonghua Hu and Min Zhang
    Citation: Veterinary Research 2021 52:32
  35. Animal tuberculosis (TB) is a multi-host disease caused by members of the Mycobacterium tuberculosis complex (MTC). Due to its impact on economy, sanitary standards of milk and meat industry, public health and co...

    Authors: Jobin Thomas, Ana Balseiro, Christian Gortázar and María A. Risalde
    Citation: Veterinary Research 2021 52:31
  36. Host proteins interacting with pathogens are receiving more attention as potential therapeutic targets in molecular medicine. Streptococcus suis serotype 2 (SS2) is an important cause of meningitis in both humans...

    Authors: Hongtao Liu, Siyu Lei, Li Jia, Xiaojing Xia, Yingying Sun, Hexiang Jiang, Rining Zhu, Shuguang Li, Guanggang Qu, Jingmin Gu, Changjiang Sun, Xin Feng, Wenyu Han, Paul R. Langford and Liancheng Lei
    Citation: Veterinary Research 2021 52:30
  37. Rhomboid-like proteases (ROMs) are considered as new candidate antigens for developing new-generation vaccines due to their important role involved in the invasion of apicomplexan protozoa. In prior works, we ...

    Authors: Yufeng Chen, Di Tian, Lixin Xu, Ruofeng Yan, Xiangrui Li, Muhammad Ali A. Shah and Xiaokai Song
    Citation: Veterinary Research 2021 52:29
  38. CD9 is a glycoprotein of the transmembrane 4 superfamily that is involved in various cellular processes. Studies related to the immune functions and activities of CD9 in teleost fish are limited. In this study...

    Authors: Jiaojiao He, Hanjie Gu, Wenqi Wang and Yonghua Hu
    Citation: Veterinary Research 2021 52:28
  39. Gallibacterium anatis is a common cause of reproductive tract infection in chickens, which leads to reduced egg production and increased mortality. This study was undertaken to investigate prevalence of G. anatis

    Authors: Toloe Allahghadry, Duncan Y. K. Ng, Alireza Dibaei and Anders Miki Bojesen
    Citation: Veterinary Research 2021 52:27
  40. Porcine epidemic diarrhea virus (PEDV) primarily infects neonatal piglets causing catastrophic effects on the global pig farming industry. PEDV infects piglets through the nasal cavity, a process in which dend...

    Authors: Chen Yuan, Yuxin Jin, Yuchen Li, En Zhang, Penghao Zhang and Qian Yang
    Citation: Veterinary Research 2021 52:26
  41. Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly contagious virus that has led to enormous economic loss worldwide because of ineffective prevention and treatment. In view of their minim...

    Authors: Lu Zhang, Lizhen Wang, Shuaishuai Cao, Huanhuan Lv, Jingjing Huang, Guixi Zhang, Kaissar Tabynov, Qin Zhao and En-Min Zhou
    Citation: Veterinary Research 2021 52:25
  42. Avian coccidiosis caused by Eimeria leads to huge economic losses on the global poultry industry. In this study, microneme adhesive repeat regions (MARR) bc1 of E. tenella microneme protein 3 (EtMIC3-bc1) was use...

    Authors: Wenjing Chen, Chunli Ma, Guanghao Li, Zhipeng Jia, Xuelian Yang, Xinghui Pan and Dexing Ma
    Citation: Veterinary Research 2021 52:24
  43. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xiu Li Feng, Yang Zheng, Man Man Zong, Shan Shan Hao, Guang Fang Zhou, Rui Bing Cao, Pu Yan Chen and Qing Tao Liu
    Citation: Veterinary Research 2021 52:23

    The original article was published in Veterinary Research 2019 50:64

  44. COVID-19 is a zoonotic disease caused by SARS-CoV-2. Infections of animals with SARS-CoV-2 have recently been reported, and an increase of severe lung pathologies in domestic dogs has also been detected by vet...

    Authors: Ana Judith Perisé-Barrios, Beatriz Davinia Tomeo-Martín, Pablo Gómez-Ochoa, Pablo Delgado-Bonet, Pedro Plaza, Paula Palau-Concejo, Jorge González, Gustavo Ortiz-Díez, Antonio Meléndez-Lazo, Michaela Gentil, Javier García-Castro and Alicia Barbero-Fernández
    Citation: Veterinary Research 2021 52:22
  45. The skin is a passive and active barrier which protects the body from the environment. Its health is essential for the accomplishment of this role. Since several decades, the skin has aroused a strong interest...

    Authors: Laurent Souci and Caroline Denesvre
    Citation: Veterinary Research 2021 52:21
  46. Processing and packaging of herpesvirus genomic DNA is regulated by a packaging-associated terminase complex comprising of viral proteins pUL15, pUL28 and pUL33. Marek’s disease virus (MDV) homologs UL28 and U...

    Authors: Aijun Sun, Shuaikang Yang, Jun Luo, Man Teng, Yijie Xu, Rui Wang, Xiaojing Zhu, Luping Zheng, Yanan Wu, Yongxiu Yao, Venugopal Nair, Gaiping Zhang and Guoqing Zhuang
    Citation: Veterinary Research 2021 52:20
  47. This study reports the comparative analyses of four Flavobacterium columnare isolates that have different virulence and antimicrobial resistance patterns. The main research goal was to reveal new insights into po...

    Authors: Annelies Maria Declercq, Laurentijn Tilleman, Yannick Gansemans, Chloë De Witte, Freddy Haesebrouck, Filip Van Nieuwerburgh, Annemieke Smet and Annemie Decostere
    Citation: Veterinary Research 2021 52:18

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