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  1. Bluetongue disease is caused by bluetongue virus (BTV) and BTV serotype 8 (BTV8) caused great economic damage in Europe during the last decade. From 1998 to 2007, in addition to BTV8, Europe had to face the em...

    Authors: Ludovic Martinelle, Fabiana Dal Pozzo, Christine Thys, Ilse De Leeuw, Willem Van Campe, Kris De Clercq, Etienne Thiry and Claude Saegerman
    Citation: Veterinary Research 2018 49:63
    Content type: Research article Published on:

  2. Peste des petits ruminants virus (PPRV) belongs to the genus Morbillivirus that causes an acute and highly contagious disease in goats and sheep. Virus infection can trigger the change in the cellular microRNA (m...

    Authors: Xuefeng Qi, Ting Wang, Qinghong Xue, Zhen Li, Bo Yang and Jingyu Wang
    Citation: Veterinary Research 2018 49:62
    Content type: Research article Published on:

  3. The mass vaccination of dogs is a proven tool for rabies prevention. Besides parenteral delivery of inactivated vaccines, over the past several decades, several self-replicating biologics, including modified-l...

    Authors: Florence Cliquet, Anne-Laure Guiot, Michel Aubert, Emmanuelle Robardet, Charles E. Rupprecht and François-Xavier Meslin
    Citation: Veterinary Research 2018 49:61
    Content type: Review Published on:

    The Correction to this article has been published in Veterinary Research 2018 49:84

  4. Paratuberculosis, a gastrointestinal disease caused by Mycobacterium avium subsp. paratuberculosis (Map), can lead to severe economic losses in dairy cattle farms. Current measures are aimed at controlling preval...

    Authors: Guillaume Camanes, Alain Joly, Christine Fourichon, Racem Ben Romdhane and Pauline Ezanno
    Citation: Veterinary Research 2018 49:60
    Content type: Research article Published on:

  5. In our previous work, a Trichinella spiralis putative serine protease (TsSP) was identified from ES products of T. spiralis intestinal infective larvae (IIL) and adult worms (AW) by immunoproteomics: it was highl...

    Authors: Ge Ge Sun, Hua Nan Ren, Ruo Dan Liu, Yan Yan Song, Xin Qi, Chen Xi Hu, Fan Yang, Peng Jiang, Xi Zhang, Zhong Quan Wang and Jing Cui
    Citation: Veterinary Research 2018 49:59
    Content type: Research article Published on:

  6. Mycobacterium avium subspecies paratuberculosis (Map) is the cause of Johne’s disease, a chronic enteritis of cattle. A significant knowledge gap is how persistence of Map within the intestinal tract after infect...

    Authors: Kevin J. Stinson, Monica M. Baquero and Brandon L. Plattner
    Citation: Veterinary Research 2018 49:58
    Content type: Research Article Published on:

  7. The obligate intracellular pathogen Lawsonia intracellularis (LI), the etiological agent of proliferative enteropathy (PE), poses a substantial economic loss in the swine industry worldwide. In this study, we gen...

    Authors: Suyeon Park, Gayeon Won, Jehyoung Kim, Hyeun Bum Kim and John Hwa Lee
    Citation: Veterinary Research 2018 49:57
    Content type: Research article Published on:

  8. The expression of T regulatory cells (Foxp3), regulatory (interleukin [IL]-10 and transforming growth factor beta [TGF-β]) and proinflammatory (tumor necrosis factor alpha [TNF-α] and interleukin [IL]-1β) cyto...

    Authors: Isabel L. Pacheco, Nieves Abril, Rafael Zafra, Verónica Molina-Hernández, Noelia Morales-Prieto, María J. Bautista, María T. Ruiz-Campillo, Raúl Pérez-Caballero, Alvaro Martínez-Moreno and José Pérez
    Citation: Veterinary Research 2018 49:56
    Content type: Research article Published on:

  9. Canine respiratory coronavirus (CRCoV), identified in 2003, is a member of the Coronaviridae family. The virus is a betacoronavirus and a close relative of human coronavirus OC43 and bovine coronavirus. Here, we ...

    Authors: Artur Szczepanski, Katarzyna Owczarek, Aleksandra Milewska, Zbigniew Baster, Zenon Rajfur, Judy A. Mitchell and Krzysztof Pyrc
    Citation: Veterinary Research 2018 49:55
    Content type: Research article Published on:

  10. Cattle are an economically important domestic animal species. In vitro 2D cultures of intestinal epithelial cells or epithelial cell lines have been widely used to study cell function and host–pathogen interac...

    Authors: Carly A. Hamilton, Rachel Young, Siddharth Jayaraman, Anuj Sehgal, Edith Paxton, Sarah Thomson, Frank Katzer, Jayne Hope, Elisabeth Innes, Liam J. Morrison and Neil A. Mabbott
    Citation: Veterinary Research 2018 49:54
    Content type: Research article Published on:

  11. Efforts to develop live attenuated vaccines against Mycobacterium avium subspecies paratuberculosis (Map), using indirect methods to screen Map deletion mutants for potential efficacy, have not been successful. A...

    Authors: Gaber S. Abdellrazeq, Mahmoud M. Elnaggar, John P. Bannantine, Kun T. Park, Cleverson D. Souza, Brian Backer, Victoria Hulubei, Lindsay M. Fry, Samy A. Khaliel, Helmy A. Torky, David A. Schneider and William C. Davis
    Citation: Veterinary Research 2018 49:53
    Content type: Research article Published on:

  12. Duck hepatitis A virus 3 (DHAV-3), the only member of the novel genus Avihepatovirus, in the family Picornaviridae, can cause significant economic losses for duck farms in China. Reports on the pathogenicity and ...

    Authors: Xuelian Zhang, Chong Cao, Yue Liu, Haihui Qi, Wenjing Zhang, Chunxue Hao, Haotian Chen, Qi Zhang, Wenlong Zhang, Mingchun Gao, Junwei Wang and Bo Ma
    Citation: Veterinary Research 2018 49:52
    Content type: Research article Published on:

  13. Intestinal health is critically important for the welfare and performance of poultry. Enteric diseases that cause gut barrier failure result in high economic losses. Up till now there is no reliable faecal mar...

    Authors: Evy Goossens, Griet Debyser, Chana Callens, Maarten De Gussem, Annelike Dedeurwaerder, Bart Devreese, Freddy Haesebrouck, Monika Flügel, Stefan Pelzer, Frank Thiemann, Richard Ducatelle and Filip Van Immerseel
    Citation: Veterinary Research 2018 49:51
    Content type: Research article Published on:

  14. Bovine leukemia virus (BLV) is a retrovirus that infects B cells in cattle and causes bovine leukosis after a long latent period. Progressive exhaustion of T cell functions is considered to facilitate disease ...

    Authors: Tomohiro Okagawa, Satoru Konnai, Asami Nishimori, Naoya Maekawa, Shinya Goto, Ryoyo Ikebuchi, Junko Kohara, Yasuhiko Suzuki, Shinji Yamada, Yukinari Kato, Shiro Murata and Kazuhiko Ohashi
    Citation: Veterinary Research 2018 49:50
    Content type: Research article Published on:

  15. Pigs are popular animal models in biomedical research. RNA-Seq is becoming the predominant tool to investigate transcriptional changes of the pig’s response to infection. The high sensitivity of this tool requ...

    Authors: Naíla C. do Nascimento, Ana M. S. Guimaraes, Andrea P. dos Santos, Yuefeng Chu, Lucas M. Marques and Joanne B. Messick
    Citation: Veterinary Research 2018 49:49
    Content type: Research article Published on:

  16. Streptococcus (S.) suis is an important porcine pathogen causing meningitis, arthritis and septicemia. As cps7 emerged recently in Germany in association with severe herd problems, the objective of this study was...

    Authors: Karoline Rieckmann, Anna Seydel, Kristin Szewczyk, Kerstin Klimke, Viktoria Rungelrath and Christoph Georg Baums
    Citation: Veterinary Research 2018 49:48
    Content type: Research article Published on:

  17. Intramammary infections (IMI) are prevalent in non-lactating dairy cattle and their occurrence during periods of significant mammary growth and development (i.e. pregnant heifers and dry cows) is believed to i...

    Authors: Benjamin D. Enger, Carly E. Crutchfield, Taylor T. Yohe, Kellie M. Enger, Stephen C. Nickerson, Catherine L. M. Parsons and Robert Michael Akers
    Citation: Veterinary Research 2018 49:47
    Content type: Research article Published on:

  18. Lagovirus europaeus GI.2, also known as RHDV2 or RHDVb, is an emerging virus that causes rabbit haemorrhagic disease (RHD) in European rabbits (Oryctolagus cuniculus). In contrast to L. europaeus GI.1 (or RHDV/RH...

    Authors: Aleksija Neimanis, Ulrika Larsson Pettersson, Nina Huang, Dolores Gavier-Widén and Tanja Strive
    Citation: Veterinary Research 2018 49:46
    Content type: Research article Published on:

  19. Information on the in vitro growth of pathogenic and non-pathogenic Mycoplasma hyopneumoniae (M. hyopneumoniae) strains is scarce and controversial. Despite its limitations, the colour changing units (CCU) assay ...

    Authors: Beatriz Garcia-Morante, Arkadius Dors, Rocio León-Kempis, Ana Pérez de Rozas, Joaquim Segalés and Marina Sibila
    Citation: Veterinary Research 2018 49:45
    Content type: Research article Published on:

  20. Bagaza virus (BAGV; synonymous to Israel turkey meningoencephalomyelitis virus, ITV) is a relevant arthropod-borne epornitic flavivirus. In its first emergence in Europe (southern Spain, 2010) BAGV caused an o...

    Authors: Cristina Cano-Gómez, Francisco Llorente, Elisa Pérez-Ramírez, Ramón C. Soriguer, Mathieu Sarasa and Miguel Ángel Jiménez-Clavero
    Citation: Veterinary Research 2018 49:44
    Content type: Short report Published on:

  21. Intestinal health is determined by host (immunity, mucosal barrier), nutritional, microbial and environmental factors. Deficiencies in intestinal health are associated with shifts in the composition of the int...

    Authors: Richard Ducatelle, Evy Goossens, Fien De Meyer, Venessa Eeckhaut, Gunther Antonissen, Freddy Haesebrouck and Filip Van Immerseel
    Citation: Veterinary Research 2018 49:43
    Content type: Review Published on:

  22. Experimental infections in pregnant sheep have been focused on studying the effect of the time of challenge on the outcome of N. caninum infection, whereas the impact of the dose and route of challenge has not be...

    Authors: Roberto Sánchez-Sánchez, Ignacio Ferre, Michela Re, Javier Regidor-Cerrillo, Javier Blanco-Murcia, Luis Miguel Ferrer, Teresa Navarro, Manuel Pizarro Díaz, Marta González-Huecas, Enrique Tabanera, Julio Benavides and Luis Miguel Ortega-Mora
    Citation: Veterinary Research 2018 49:42
    Content type: Research article Published on:

  23. In this study, we identified a chicken liver cell line (LMH) which could strongly support the replication of ALV-J (Subgroup J of avian leukosis virus) with high viral titer. Notably, ALV-J was efficiently det...

    Authors: Tuofan Li, Jing Xie, Lu Lv, Shu Sun, Xiaomei Dong, Quan Xie, Guangcheng Liang, Chichao Xia, Hongxia Shao, Aijian Qin and Jianqiang Ye
    Citation: Veterinary Research 2018 49:41
    Content type: Short report Published on:

  24. Cyprinid herpesvirus 3 (CyHV-3) is the archetypal fish alloherpesvirus and the etiologic agent of a lethal disease in common and koi carp. To date, the genome sequences of only four CyHV-3 isolates have been p...

    Authors: Yuan Gao, Nicolás M. Suárez, Gavin S. Wilkie, Chuanfu Dong, Sven Bergmann, Pei-Yu Alison Lee, Andrew J. Davison, Alain F. C. Vanderplasschen and Maxime Boutier
    Citation: Veterinary Research 2018 49:40
    Content type: Research article Published on:

  25. The present study exploited the RNA-seq technology to analyze the transcriptome of target tissues affected by the Teladorsagia circumcincta infection in two groups of adult ewes showing different statuses against...

    Authors: Praveen K. Chitneedi, Aroa Suárez-Vega, María Martínez-Valladares, Juan José Arranz and Beatriz Gutiérrez-Gil
    Citation: Veterinary Research 2018 49:39
    Content type: Research article Published on:

  26. Clostridium novyi-NT (CVN-NT) spores germinate in hypoxic regions of tumors and have successfully cured induced neoplasia in mouse models and resulted in objective tumor responses in naturally developing neoplasi...

    Authors: Amy E. DeClue, Sandra M. Axiak-Bechtel, Yan Zhang, Saurabh Saha, Linping Zhang, David Tung and Jeffrey N. Bryan
    Citation: Veterinary Research 2018 49:38
    Content type: Research article Published on:

  27. Ichthyophthirius multifiliis is a ciliated protozoan parasite recognized as one of the most pathogenic diseases of wild and cultured freshwater fish. Fish skin mucus plays a significant role against invading path...

    Authors: Mona Saleh, Gokhlesh Kumar, Abdel-Azeem Abdel-Baki, Mohamed A. Dkhil, Mansour El-Matbouli and Saleh Al-Quraishy
    Citation: Veterinary Research 2018 49:37
    Content type: Research article Published on:

  28. Maedi-visna, a disease caused by small ruminant lentiviruses (SRLVs), is present in sheep from many countries, also including Germany. An amino acid substitution (E/K) at position 35 of the transmembrane prote...

    Authors: Vahid Molaee, Marwa Eltanany and Gesine Lühken
    Citation: Veterinary Research 2018 49:36
    Content type: Research article Published on:

  29. The minimum inhibitory concentration of bambermycin on three porcine Helicobacter suis strains was shown to be 8 μg/mL. The effect of in-feed medication with this antibiotic on the course of a gastric infection w...

    Authors: Chloë De Witte, Bernard Taminiau, Bram Flahou, Veerle Hautekiet, Georges Daube, Richard Ducatelle and Freddy Haesebrouck
    Citation: Veterinary Research 2018 49:35
    Content type: Research article Published on:

  30. Marine herpesviruses are responsible for epizootics in economically, ecologically and culturally significant taxa. The recent emergence of microvariants of Ostreid herpesvirus 1 (OsHV-1) in Pacific oysters Crasso...

    Authors: Richard J. Whittington, Ika Paul-Pont, Olivia Evans, Paul Hick and Navneet K. Dhand
    Citation: Veterinary Research 2018 49:34
    Content type: Research article Published on:

  31. The first European cases of chronic wasting disease (CWD) in free-ranging reindeer and wild elk were confirmed in Norway in 2016 highlighting the urgent need to understand transmissible spongiform encephalopat...

    Authors: José Luis Pitarch, Helen Caroline Raksa, María Cruz Arnal, Miguel Revilla, David Martínez, Daniel Fernández de Luco, Juan José Badiola, Wilfred Goldmann and Cristina Acín
    Citation: Veterinary Research 2018 49:33
    Content type: Research article Published on:

  32. Brucellosis is a zoonotic bacterial disease caused by Brucella spp. The virulence of these bacteria is dependent on their ability to invade and replicate within host cells. In a previous study, a putative gene ba...

    Authors: Mingxing Tian, Yanqing Bao, Peng Li, Hai Hu, Chan Ding, Shaohui Wang, Tao Li, Jingjing Qi, Xiaolan Wang and Shengqing Yu
    Citation: Veterinary Research 2018 49:32
    Content type: Research Published on:

  33. Marek’s disease is a multi-faceted highly contagious disease affecting chickens caused by the Marek’s disease alphaherpesvirus (MDV). MDV early infection induces a transient immunosuppression, which is associa...

    Authors: Camille Berthault, Thibaut Larcher, Sonja Härtle, Jean-François Vautherot, Laetitia Trapp-Fragnet and Caroline Denesvre
    Citation: Veterinary Research 2018 49:31
    Content type: Research article Published on:

  34. Infectious hematopoietic necrosis virus (IHNV) is endemic in farmed rainbow trout in continental Europe and in various salmonid fish species at the Pacific coast of North America. IHN has never occurred in Eur...

    Authors: Niccoló Vendramin, Anna Luiza Farias Alencar, Tine Moesgaard Iburg, Maria Krudtaa Dahle, Øystein Wessel, Anne Berit Olsen, Espen Rimstad and Niels Jørgen Olesen
    Citation: Veterinary Research 2018 49:30
    Content type: Research Article Published on:

  35. A recent outbreak of hepatitis–hydropericardium syndrome caused by serotype 4 fowl adenovirus (FAdV-4) has resulted in significant economic losses to the poultry industry worldwide. However, little is known ab...

    Authors: Ping Wang, Jianjun Zhang, Weikang Wang, Tuofan Li, Guangchen Liang, Hongxia Shao, Wei Gao, Aijian Qin and Jianqiang Ye
    Citation: Veterinary Research 2018 49:29
    Content type: Research Article Published on:

  36. The principal virulence factor of Shiga toxin (Stx)-producing Escherichia coli (STEC), the eponymous Stx, modulates cellular immune responses in cattle, the primary STEC reservoir. We examined whether immunizatio...

    Authors: Nadine Schmidt, Stefanie A. Barth, Jana Frahm, Ulrich Meyer, Sven Dänicke, Lutz Geue and Christian Menge
    Citation: Veterinary Research 2018 49:28
    Content type: Research Article Published on:

  37. This literature review of exposure to Mycobacterium avium subsp. paratuberculosis (MAP) in sheep enabled a synthesis of the patho-physiology of ovine paratuberculosis (PTB). These results could be used to inform ...

    Authors: Nelly Marquetoux, Rebecca Mitchell, Anne Ridler, Cord Heuer and Peter Wilson
    Citation: Veterinary Research 2018 49:27
    Content type: Review Published on:

  38. The European Union has implemented breeding programmes to increase scrapie resistance in sheep. A similar approach can be applied also in goats since the K222 allele provides a level of resistance equivalent t...

    Authors: Paola Sacchi, Roberto Rasero, Giuseppe Ru, Eleonora Aiassa, Silvia Colussi, Francesco Ingravalle, Simone Peletto, Maria Gabriella Perrotta, Stefano Sartore, Dominga Soglia and Pierluigi Acutis
    Citation: Veterinary Research 2018 49:26
    Content type: Research Article Published on:

  39. Intramammary infections in cattle resulting in mastitis have detrimental effects on cows’ well-being, lifespan and milk production. In the host defense against S. aureus mastitis antibodies are thought to play an...

    Authors: Eveline M. Boerhout, Ad P. Koets, Tanja G. T. Mols-Vorstermans, Piet J. M. Nuijten, Mathieu J. H. Hoeijmakers, Victor P. M. G. Rutten and Jetta J. E. Bijlsma
    Citation: Veterinary Research 2018 49:25
    Content type: Research Article Published on:

  40. Severe economic losses due to diseases in marine larviculture may be linked to vibriosis. To better understand the pathogenesis of vibriosis and evaluate new ways to prevent and combat this important disease, ...

    Authors: Evelien De Swaef, Maaike Vercauteren, Luc Duchateau, Freddy Haesebrouck and Annemie Decostere
    Citation: Veterinary Research 2018 49:24
    Content type: Research Article Published on:

  41. The binding of F4+ enterotoxigenic Escherichia coli (ETEC) and the specific receptor on porcine intestinal epithelial cells is the initial step in F4+ ETEC infection. Porcine aminopeptidase N (APN) is a newly dis...

    Authors: Pengpeng Xia, Guomei Quan, Yi Yang, Jing Zhao, Yiting Wang, Mingxu Zhou, Philip R. Hardwidge, Jianzhong Zhu, Siguo Liu and Guoqiang Zhu
    Citation: Veterinary Research 2018 49:23
    Content type: Research Article Published on:

  42. Staphylococcus aureus is a major pathogen that causes subclinical mastitis associated with huge economic losses to the dairy industry. A few vaccines for bovine mastitis are available, and they are expected to in...

    Authors: Mutsumi Furukawa, Hiroshi Yoneyama, Eiji Hata, Hidetomo Iwano, Hidetoshi Higuchi, Tasuke Ando, Mika Sato, Tomohito Hayashi, Yoshio Kiku, Yuya Nagasawa, Kanae Niimi, Katsuki Usami, Kumiko Ito, Kouichi Watanabe, Tomonori Nochi and Hisashi Aso
    Citation: Veterinary Research 2018 49:22
    Content type: Research Article Published on:

  43. The aim of this work was to evaluate the immunogenicity and efficacy of DNA and MVA vaccines encoding the RVFV glycoproteins Gn and Gc in an ovine model of RVFV infection. Adult sheep of both sexes were challe...

    Authors: Gema Lorenzo, Elena López-Gil, Javier Ortego and Alejandro Brun
    Citation: Veterinary Research 2018 49:21
    Content type: Research Article Published on:

  44. Diarrhea remains one of the leading causes of morbidity and mortality globally, with enterotoxigenic Escherichia coli (ETEC) constituting a major causative pathogen. The development of alternative treatments for ...

    Authors: Guangping Huang, Xiangqing Li, Dan Lu, Shen Liu, Xun Suo, Qiuyan Li and Ning Li
    Citation: Veterinary Research 2018 49:20
    Content type: Research Article Published on:

  45. Porcine reproductive and respiratory syndrome virus (PRRSv) infection alters the host’s cellular and humoral immune response. Immunity against PRRSv is multigenic and vary between individuals. The aim of the p...

    Authors: Martí Cortey, Gaston Arocena, Tahar Ait-Ali, Anna Vidal, Yanli Li, Gerard Martín-Valls, Alison D. Wilson, Allan L. Archibald, Enric Mateu and Laila Darwich
    Citation: Veterinary Research 2018 49:19
    Content type: Short Report Published on:

  46. Porcine circovirus type 2 (PCV2) is the primary cause of post-weaning multisystemic wasting syndrome (PMWS) and other PCV-associated diseases. According to our previous RNA-sequencing analysis, the differences...

    Authors: Ping Zhang, Liyuan Wang, Yanping Li, Ping Jiang, Yanchao Wang, Pengfei Wang, Li Kang, Yuding Wang, Yi Sun and Yunliang Jiang
    Citation: Veterinary Research 2018 49:18
    Content type: Research Article Published on:

  47. The obligate intracellular Lawsonia intracellularis (LI), the etiological agent of proliferative enteropathy (PE), is an economically important disease in the swine industry. Due to extreme difficulty of in vitro...

    Authors: Gayeon Won and John Hwa Lee
    Citation: Veterinary Research 2018 49:17
    Content type: Research Article Published on:

  48. Cell-penetrating peptide (CPP) is a promising cargo for delivering bioactive molecules. In this study, the N terminus of VP1 from chicken anemia virus, designated as CVP1, was found to carry enriched arginine ...

    Authors: Gaowei Hu, Wenlv Zheng, Ao Li, Yaru Mu, Mingyu Shi, Tuofan Li, Haitao Zou, Hongxia Shao, Aijian Qin and Jianqiang Ye
    Citation: Veterinary Research 2018 49:16
    Content type: Research Article Published on:

  49. Porcine circovirus type 2 (PCV2) is recognized as the causative agent of porcine circovirus-associated diseases. PCV2 replication could be promoted by low doses of ochratoxin A (OTA) as in our previous study a...

    Authors: Gang Qian, Dandan Liu, Junfa Hu, Fang Gan, Lili Hou, Nianhui Zhai, Xingxiang Chen and Kehe Huang
    Citation: Veterinary Research 2018 49:15
    Content type: Research Article Published on:

  50. Swinepox virus (SPV) has several advantages as a potential clinical vector for a live vector vaccine. In this study, to obtain a safer and more efficient SPV vector, three SPV mutants, Δ003, Δ010, and ΔTK were...

    Authors: Xiaomin Yuan, Huixing Lin, Bin Li, Kongwang He and Hongjie Fan
    Citation: Veterinary Research 2018 49:14
    Content type: Research Article Published on:
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