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  1. Biomedical research relies on the use of animal models, and the animals used in those models receive medical care, including antibiotics for brief periods of time to treat conditions such as dermatitis, fight ...

    Authors: Scott W. Korte, Rebecca A. Dorfmeyer, Craig L. Franklin and Aaron C. Ericsson
    Citation: Veterinary Research 2020 51:116
    Content type: Research article Published on:

  2. Chickens are highly susceptible to highly pathogenic avian influenza viruses (HPAIVs). However, the severity of infection varies depending of the viral strain and the genetic background of the host. In this st...

    Authors: Raúl Sánchez-González, Antonio Ramis, Miquel Nofrarías, Nabil Wali, Rosa Valle, Mónica Pérez, Albert Perlas and Natàlia Majó
    Citation: Veterinary Research 2020 51:113
    Content type: Research article Published on:

  3. To increase expression levels of the PCV2 Cap(d41) protein, novel baculovirus surface display vectors with multiple expression cassettes were constructed to create recombinant baculoviruses BacSC-Cap(d41), Bac...

    Authors: Ya-Yi Chen, Wei-Chen Yang, Yu-Kang Chang, Chi-Young Wang, Wei-Ru Huang, Jyun-Yi Li, Kuo-Pin Chuang, Hung-Yi Wu, Ching-Dong Chang, Brent L. Nielsen and Hung-Jen Liu
    Citation: Veterinary Research 2020 51:112
    Content type: Research article Published on:

  4. In our previous studies, a novel T. spiralis peptidase (TsP) was identified among the excretory/secretory (ES) proteins of T. spiralis intestinal infective larvae (IIL) and T. spiralis at the adult worm (AW) stag...

    Authors: Jun Jun Lei, Yuan Yuan Hu, Fang Liu, Shu Wei Yan, Ruo Dan Liu, Shao Rong Long, Peng Jiang, Jing Cui and Zhong Quan Wang
    Citation: Veterinary Research 2020 51:111
    Content type: Research article Published on:

  5. Canine parvovirus (CPV) can cause acute and highly contagious bloody enteritis in dog. To obtain antibodies against CPV, hens were immunized with virus-like particles (VLP) of CPV-VP2. The IgY single chain fra...

    Authors: Shikun Ge, Long Xu, Ben Li, Fagang Zhong, Xiang Liu and Xiaoying Zhang
    Citation: Veterinary Research 2020 51:110
    Content type: Research article Published on:

  6. Francisella tularensis subsp. holarctica is a select agent causing life-threatening tularemia. It has been isolated from humans and animals, mainly lagomorphs and rodents, rarely other wild carnivore species. Inc...

    Authors: Sonja Kittl, Thierry Francey, Isabelle Brodard, Francesco C. Origgi, Stéphanie Borel, Marie-Pierre Ryser-Degiorgis, Ariane Schweighauser and Joerg Jores
    Citation: Veterinary Research 2020 51:109
    Content type: Short report Published on:

  7. Defective interfering particles (DIPs) of influenza virus are generated through incorporation of highly truncated forms of genome segments, mostly those coding polymerase complex proteins (PB2, PB1, PA). Such ...

    Authors: Edyta Świętoń, Karolina Tarasiuk and Krzysztof Śmietanka
    Citation: Veterinary Research 2020 51:108
    Content type: Research article Published on:

  8. Trichinella spiralis maintains chronic infections within its host. Muscle larvae excretory-secretory products (MLES) typically induce parasite-specific immune responses such as the Th2 response and regulatory T c...

    Authors: Xuemin Jin, Xue Bai, Yong Yang, Jing Ding, Haining Shi, Baoquan Fu, Pascal Boireau, Mingyuan Liu and Xiaolei Liu
    Citation: Veterinary Research 2020 51:107
    Content type: Research article Published on:

  9. Haemonchus contortus is a hematophagous endoparasite of small ruminants, which is responsible for huge economic losses in livestock sector. Hyaluronidase produced by infective larvae of H. contortus can degrade h...

    Authors: Xiangshu Yang, Sawar Khan, Xiaochao Zhao, Jiayan Zhang, Ayesha Nisar and Xingang Feng
    Citation: Veterinary Research 2020 51:106
    Content type: Research article Published on:

  10. Neutrophils are the first barriers for resisting the invasion, proliferation, and damage caused by Salmonella Typhimurium. However, the mechanisms that control this resistance are not completely understood. In th...

    Authors: Tinghua Huang, Caiyun Jiang, Min Yang, Hong Xiao, Xiali Huang, Lingbo Wu and Min Yao
    Citation: Veterinary Research 2020 51:105
    Content type: Research article Published on:

  11. Porcine reproductive and respiratory syndrome (PRRS) caused by PRRS virus (PRRSV) is one of the most severe swine diseases that affects almost all swine-breeding countries. Nonstructural protein 2 (NSP2) is on...

    Authors: Shengliang Cao, Jiaqi Liu, Guofei Ding, Qingyuan Shao, Bin Wang, Yingchao Li, Jian Feng, Yuzhong Zhao, Sidang Liu and Yihong Xiao
    Citation: Veterinary Research 2020 51:104
    Content type: Research article Published on:

  12. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Guowei Xu, Shouxing Xu, Xijuan Shi, Chaochao Shen, Junhong Hao, Minhao Yan, Dajun Zhang, Zixiang Zhu, Keshan Zhang, Haixue Zheng and Xiangtao Liu
    Citation: Veterinary Research 2020 51:103
    Content type: Correction Published on:

    The original article was published in Veterinary Research 2020 51:91

  13. Glaesserella parasuis (G. parasuis) causes porcine vascular inflammation and damage. Baicalin is reported to have antioxidant and anti-inflammatory functions. However, whether baicalin protects piglets against G....

    Authors: Shulin Fu, Ronghua Yin, Sanling Zuo, Jun Liu, Yunfei Zhang, Ling Guo, Yinsheng Qiu, Chun Ye, Yu Liu, Zhongyuan Wu, Yongqing Hou and Chien-An Andy Hu
    Citation: Veterinary Research 2020 51:102
    Content type: Research article Published on:

  14. Brucella ovis is a non-zoonotic rough Brucella that causes genital lesions, abortions and increased perinatal mortality in sheep and is responsible for important economic losses worldwide. Research on virulence f...

    Authors: Nieves Vizcaíno, Lara Pérez-Etayo, Raquel Conde-Álvarez, Maite Iriarte, Ignacio Moriyón and Amaia Zúñiga-Ripa
    Citation: Veterinary Research 2020 51:101
    Content type: Research article Published on:

  15. Matrix metalloproteinases (MMPs) play an important role in intestinal extracellular matrix homeostasis. An overexpression of MMPs results in tissue destruction and local inflammation and has been associated wi...

    Authors: Lore Van Damme, Natasja Cox, Chana Callens, Freddy Haesebrouck, Michelle Dargatz, Richard Ducatelle, Filip Van Immerseel and Evy Goossens
    Citation: Veterinary Research 2020 51:100
    Content type: Research article Published on:

  16. Probiotics as an effective and safe strategy for controlling Salmonella infection are much sought after, while autophagy is a central issue in eliminating intracellular pathogens of intestinal epithelial cells. I...

    Authors: Bingxin Chu, Yaohong Zhu, Jinhui Su, Bing Xia, Yunjing Zou, Jiawei Nie, Wei Zhang and Jiufeng Wang
    Citation: Veterinary Research 2020 51:99
    Content type: Research article Published on:

  17. Streptococcus agalactiae is one of the causative agents of subclinical mastitis, a common disease of dairy cows that causes great economic losses in the industry worldwide. It is thought that pathology is mainly ...

    Authors: Jinjin Tong, Mingwei Sun, Hua Zhang, Delian Yang, Yonghong Zhang, Benhai Xiong and Linshu Jiang
    Citation: Veterinary Research 2020 51:98
    Content type: Research article Published on:

  18. Lipooligosaccharides (LOSs) are virulence determinants of Glaesserella parasuis, a pathogen of the respiratory tract of pigs. We previously reported that disruption of the galU or galE gene in G. parasuis results...

    Authors: Saixiang Feng, Aihua Chen, Xiaobing Wang, Zhichao Pan, Siqi Xu, Huiwen Yu, Bin Zhang and Ming Liao
    Citation: Veterinary Research 2020 51:97
    Content type: Research article Published on:

  19. We analyzed the pathogenicity of a recent Japanese classical swine fever virus (CSFV) to wild boars via an experimental infection using boar-pig hybrids as an alternative to wild boars. We also investigated th...

    Authors: Katsuhiko Fukai, Tatsuya Nishi, Manabu Yamada and Mitsutaka Ikezawa
    Citation: Veterinary Research 2020 51:96
    Content type: Short report Published on:

  20. The prevalence of TW I-type infectious bronchitis virus (IBV) has been increasing rapidly, and it has become the second most common genotype of IBV in China threatening the poultry industry. In this study, 1-d...

    Authors: Xiaorong Zhang, Kai Liao, Shuqin Chen, Kun Yan, Xubin Du, Chengcheng Zhang, Mengjiao Guo and Yantao Wu
    Citation: Veterinary Research 2020 51:95
    Content type: Research article Published on:

  21. The efficacy of anthelmintic therapy of farm animals rapidly decreases due to drug resistance development in helminths. In resistant isolates, the increased expression and activity of drug-metabolizing enzymes...

    Authors: Pavlína Kellerová, Lucie Raisová Stuchlíková, Petra Matoušková, Karolína Štěrbová, Jiří Lamka, Martina Navrátilová, Ivan Vokřál, Barbora Szotáková and Lenka Skálová
    Citation: Veterinary Research 2020 51:94
    Content type: Research article Published on:

  22. Fimbriae-mediated initial adherence is the initial and critical step required for enterotoxigenic Escherichia coli (ETEC) infection. Therefore, vaccine candidates have been developed that target these fimbriae an...

    Authors: Qiangde Duan, Shengmei Pang, Wenwen Wu, Boyu Jiang, Weiping Zhang, Siguo Liu, Xiaojun Wang, Zhiming Pan and Guoqiang Zhu
    Citation: Veterinary Research 2020 51:93
    Content type: Research article Published on:

  23. Brucella is a genus of gram-negative bacteria that cause brucellosis. B. abortus and B. melitensis infect domestic ruminants while B. suis (biovars 1–3) infect swine, and all these bacteria but B. suis biovar 2 a...

    Authors: Beatriz Aragón-Aranda, María Jesús de Miguel, Leticia Lázaro-Antón, Miriam Salvador-Bescós, Amaia Zúñiga-Ripa, Ignacio Moriyón, Maite Iriarte, Pilar M. Muñoz and Raquel Conde-Álvarez
    Citation: Veterinary Research 2020 51:92
    Content type: Research article Published on:

  24. Seneca Valley virus (SVV) is a non-encapsulated single-stranded positive-strand RNA virus whose transmission routes have not yet been fully elucidated. Exosomes have been implicated in the intercellular transp...

    Authors: Guowei Xu, Shouxing Xu, Xijuan Shi, Chaochao Shen, Junhong Hao, Minhao Yan, Dajun Zhang, Zixiang Zhu, Keshan Zhang, Haixue Zheng and Xiangtao Liu
    Citation: Veterinary Research 2020 51:91
    Content type: Research article Published on:

    The Correction to this article has been published in Veterinary Research 2020 51:103

  25. Avian coccidian parasites exhibit a high degree of site specificity in different Eimeria species. Although the underlying mechanism is unclear, an increasing body of evidence suggests that site specificity is due...

    Authors: Wenyu Li, Mingyue Wang, Yufeng Chen, Chen Chen, Xiaoqian Liu, Xiaoting Sun, Chuanxu Jing, Lixin Xu, Ruofeng Yan, Xiangrui Li and Xiaokai Song
    Citation: Veterinary Research 2020 51:90
    Content type: Research article Published on:

  26. The disease caused by duck Tembusu virus (DTMUV) is characterized by severe egg-drop in laying ducks. Currently, the disease has spread to most duck-raising areas in China, leading to great economic losses in ...

    Authors: Ning Li, Jun Zhao, Yudong Yang, Yongqing Zeng and Sidang Liu
    Citation: Veterinary Research 2020 51:87
    Content type: Review Published on:

  27. Influenza A viruses evolve rapidly to escape host immunity. In swine, this viral evolution has resulted in the emergence of multiple H1 and H3 influenza A virus (IAV) lineages in the United States (US) pig pop...

    Authors: Chong Li, Marie R. Culhane, Maxim Cheeran, Lucina Galina Pantoja, Micah L. Jansen, Deborah Amodie, Martha A. Mellencamp and Montserrat Torremorell
    Citation: Veterinary Research 2020 51:89
    Content type: Research article Published on:

  28. Avian Metapneumovirus (aMPV) has been recognized as a respiratory pathogen of turkey and chickens for a long time. Recently, a crescent awareness of aMPV, especially subtype B, clinical and economic impact has...

    Authors: Giovanni Franzo, Matteo Legnardi, Giulia Mescolini, Claudia Maria Tucciarone, Caterina Lupini, Giulia Quaglia, Elena Catelli and Mattia Cecchinato
    Citation: Veterinary Research 2020 51:88
    Content type: Research article Published on:

  29. Continued reports of infections with infectious bronchitis virus (IBV) variants have occurred since its first isolation in the 1930s. Currently, QX-like IBVs are the predominant circulating genotype around the...

    Authors: Lei Shao, Jing Zhao, Lihua Li, Xiuying Huang, Huiming Yang, Jinlong Cheng, Changqing Liu and Guozhong Zhang
    Citation: Veterinary Research 2020 51:86
    Content type: Research article Published on:

  30. Streptococcus (S.) suis is a globally important swine pathogen, which comprises certain zoonotic serotypes. In this study, a detailed characterization of 88 porcine S. suis isolates was performed by analyzing cap...

    Authors: Simone Scherrer, Giuliana Rosato, Nathalie Spoerry Serrano, Marc J. A. Stevens, Fenja Rademacher, Jacques Schrenzel, Marcelo Gottschalk, Roger Stephan and Sophie Peterhans
    Citation: Veterinary Research 2020 51:85
    Content type: Research article Published on:

  31. Newcastle disease (ND), which is caused by Newcastle disease virus (NDV), can cause heavy economic losses to the poultry industry worldwide. It is characterised by extensive pathologies of the digestive, respi...

    Authors: Zaib Ur Rehman, Shanhui Ren, Bin Yang, Xiaofeng Yang, Salman Latif Butt, Alia Afzal, Muhammad Irfan Malik, Yingjie Sun, Shengqing Yu, Chunchun Meng and Chan Ding
    Citation: Veterinary Research 2020 51:84
    Content type: Research article Published on:

  32. Neospora caninum is an apicomplexan cyst-forming parasite that is considered one of the main causes of abortion. The pathogenic mechanisms associated with parasite virulence at the maternal-foetal interface that ...

    Authors: Laura Jiménez-Pelayo, Marta García-Sánchez, Esther Collantes-Fernández, Javier Regidor-Cerrillo, Pilar Horcajo, Daniel Gutiérrez-Expósito, José Espinosa, Julio Benavides, Koldo Osoro, Christiane Pfarrer and Luis Miguel Ortega-Mora
    Citation: Veterinary Research 2020 51:83
    Content type: Research article Published on:

  33. In a study originally designed to find potential risk factors for bovine spongiform encephalopathy (BSE) we examined tissues from 403 Holstein Frisian cattle in total. These included 20 BSE cattle and their 23...

    Authors: Insa Dammann, Wiebke M. Wemheuer, Arne Wrede, Wilhelm E. Wemheuer, Amely Campe, Jutta Petschenka, Ulf Schulze-Sturm, Uwe Hahmann, Claus P. Czerny, Pia Münster, Bertram Brening, Lothar Kreienbrock, Christiane Herden and Walter J. Schulz-Schaeffer
    Citation: Veterinary Research 2020 51:82
    Content type: Research article Published on:

    The Correction to this article has been published in Veterinary Research 2020 51:130

  34. Climate change ranks among the most important issues globally, affecting geographic distributions of vectors and pathogens, and inducing losses in livestock production among many other damaging effects. We cha...

    Authors: Roberta Marques, Rodrigo F. Krüger, A. Townsend Peterson, Larissa F. de Melo, Natália Vicenzi and Daniel Jiménez-García
    Citation: Veterinary Research 2020 51:81
    Content type: Research article Published on:

  35. Understudied, coinfections are more frequent in pig farms than single infections. In pigs, the term “Porcine Respiratory Disease Complex” (PRDC) is often used to describe coinfections involving viruses such as...

    Authors: Georges Saade, Céline Deblanc, Juliette Bougon, Corinne Marois-Créhan, Christelle Fablet, Gaël Auray, Catherine Belloc, Mily Leblanc-Maridor, Carl A. Gagnon, Jianzhong Zhu, Marcelo Gottschalk, Artur Summerfield, Gaëlle Simon, Nicolas Bertho and François Meurens
    Citation: Veterinary Research 2020 51:80
    Content type: Review Published on:

  36. Encephalitozoonosis is a common infectious disease widely spread among rabbits. Encephalitozoon cuniculi, is considered as a zoonotic and emerging pathogen capable of infecting both immunocompetent and immunocomp...

    Authors: Edita Jeklova, Lenka Leva, Jan Matiasovic, Petra Ondrackova, Vladimir Kummer and Martin Faldyna
    Citation: Veterinary Research 2020 51:79
    Content type: Research article Published on:

  37. A Trichinella spiralis aminopeptidase (TsAP) has been identified in intestinal infectious larvae (IIL) and adult worms (AW), but its biological function in the T. spiralis life cycle is unknown. The aim of this s...

    Authors: Kai Xia Guo, Ying Bai, Hua Nan Ren, Xiang Yuan Sun, Yan Yan Song, Ruo Dan Liu, Shao Rong Long, Xi Zhang, Peng Jiang, Zhong Quan Wang and Jing Cui
    Citation: Veterinary Research 2020 51:78
    Content type: Research article Published on:

  38. Mastitis, inflammation of the mammary gland, is a common disease of dairy animals. The disease is caused by bacterial infection ascending through the teat canal and mammary pathogenic Escherichia coli (MPEC) are ...

    Authors: Hagit Salamon, Einat Nissim-Eliraz, Oded Ardronai, Israel Nissan and Nahum Y. Shpigel
    Citation: Veterinary Research 2020 51:77
    Content type: Research article Published on:

  39. Polyparasitism occurs when animals harbour multiple parasites concomitantly. It is a common occurrence but is generally understudied in wild and domestic animals. Fasciola hepatica and Echinococcus granulosus, wh...

    Authors: Christian Hidalgo, Caroll Stoore, Marcela Hernández and Rodolfo Paredes
    Citation: Veterinary Research 2020 51:76
    Content type: Research article Published on:

  40. Ovine enzootic abortion (OEA) caused by the obligate intracellular bacterial pathogen Chlamydia abortus (C. abortus), is an endemic disease in most sheep-rearing countries worldwide. Following infection, C. abort...

    Authors: Sean R. Wattegedera, Morag Livingstone, Stephen Maley, Mara Rocchi, Susan Lee, Yvonne Pang, Nick M. Wheelhouse, Kevin Aitchison, Javier Palarea-Albaladejo, David Buxton, David Longbottom and Gary Entrican
    Citation: Veterinary Research 2020 51:75
    Content type: Research article Published on:

  41. Q fever is a zoonosis caused by the intracellular bacterium Coxiella burnetii. In Europe, small ruminants are the main source of human Q fever. Small ruminant herds can be infectious during several lambing season...

    Authors: Hendrik I. J. Roest, Annemieke Dinkla, Ad P. Koets, Jacob Post and Lucien van Keulen
    Citation: Veterinary Research 2020 51:74
    Content type: Research article Published on:

  42. Monocytes/macrophages, which are found in a variety of organs, maintain tissue homeostasis at a steady state and act as the first line of defence during pathogen-induced inflammation in the host. Most monocyte...

    Authors: Keesun Yu, Min Jeong Gu, Young Jin Pyung, Ki-Duk Song, Tae Sub Park, Seung Hyun Han and Cheol-Heui Yun
    Citation: Veterinary Research 2020 51:73
    Content type: Research article Published on:

  43. Lipopolysaccharide (LPS) as a major component of Escherichia coli cell wall can cause inflammation and cell death. Dihydromyricetin (ampelopsin, DHM) is a natural flavonoid compound with anti-inflammatory, anti-o...

    Authors: Yicong Chang, Liang Yuan, Jiarui Liu, Ishfaq Muhammad, Chuanbao Cao, Chenxi Shi, Yuanyuan Zhang, Rui Li, Changwen Li and Fangping Liu
    Citation: Veterinary Research 2020 51:72
    Content type: Research article Published on:

  44. The type VI secretion system (T6SS) is a multiprotein weapon that kills eukaryotic predators or prokaryotic competitors by delivering toxic effectors. Despite the importance of T6SS in bacterial environmental ...

    Authors: Shuiyan Ma, Yuhao Dong, Nannan Wang, Jin Liu, Chengping Lu and Yongjie Liu
    Citation: Veterinary Research 2020 51:71
    Content type: Research article Published on:

  46. The cysteine proteases of parasites are vital contributors that induce parasite migration to and invasion of host tissue. In this study, we analysed the cysteine protease ATG4B of Trichinella spiralis (TsATG4B) i...

    Authors: Yalan Li, Baiyan Wang, Yaxin Zhu, Zhihua Tian, Zhuo Yang, Jiaqi Duan and Zhongquan Wang
    Citation: Veterinary Research 2020 51:69
    Content type: Research article Published on:

  47. Low-pathogenicity avian influenza H9N2 remains an endemic disease worldwide despite continuous vaccination, indicating the need for an improved vaccine strategy. Bacillus subtilis (B. subtilis), a gram-positive a...

    Authors: Ji Eun Lee, Yoon-Chul Kye, Sung-Moo Park, Byoung-Shik Shim, Sungsik Yoo, Eunmi Hwang, Hyungkuen Kim, Sung-Jo Kim, Seung Hyun Han, Tae Sub Park, Byung-Chul Park and Cheol-Heui Yun
    Citation: Veterinary Research 2020 51:68
    Content type: Research article Published on:

  48. In attempt to identify genes that are induced in chickens by Salmonella Enteritidis we identified a new highly inducible gene, interleukin 4 induced 1 gene (IL4I1). IL4I1 reached its peak expression (458× inducti...

    Authors: Marta Elsheimer-Matulova, Ondrej Polansky, Zuzana Seidlerova, Karolina Varmuzova, Hana Stepanova, Radek Fedr and Ivan Rychlik
    Citation: Veterinary Research 2020 51:67
    Content type: Research article Published on:

  49. The host-associated defence system responsible for the clearance of porcine reproductive and respiratory syndrome virus (PRRSV) from infected pigs is currently poorly understood. To better understand the dynam...

    Authors: Salik Nazki, Amina Khatun, Chang-Gi Jeong, Sameer ul Salam Mattoo, Suna Gu, Sim-In Lee, Seung-Chai Kim, Ji-Hyo Park, Myoun-Sik Yang, Bumseok Kim, Choi-Kyu Park, Sang-Myeong Lee and Won-Il Kim
    Citation: Veterinary Research 2020 51:66
    Content type: Research article Published on:

  50. Haemonchus contortus has evolved highly integrated and sophisticated mechanisms to promote coexistence with hosts. The excretory-secretory (ES) products generated by this parasite contribute to the regulation of ...

    Authors: Mingmin Lu, Xiaowei Tian, Zhang Yang, Wenjuan Wang, Ai-Ling Tian, Charles Li, Ruofeng Yan, Lixin Xu, Xiaokai Song and Xiangrui Li
    Citation: Veterinary Research 2020 51:65
    Content type: Research article Published on:
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