- Open Access
A survey of the transmission of infectious diseases/infections between wild and domestic ungulates in Europe
Veterinary Research volume 42, Article number: 70 (2011)
The domestic animals/wildlife interface is becoming a global issue of growing interest. However, despite studies on wildlife diseases being in expansion, the epidemiological role of wild animals in the transmission of infectious diseases remains unclear most of the time. Multiple diseases affecting livestock have already been identified in wildlife, especially in wild ungulates. The first objective of this paper was to establish a list of infections already reported in European wild ungulates. For each disease/infection, three additional materials develop examples already published, specifying the epidemiological role of the species as assigned by the authors. Furthermore, risk factors associated with interactions between wild and domestic animals and regarding emerging infectious diseases are summarized. Finally, the wildlife surveillance measures implemented in different European countries are presented. New research areas are proposed in order to provide efficient tools to prevent the transmission of diseases between wild ungulates and livestock.
Table of contents
Methodology of bibliographic research
Current status of European wild ungulates
Species and countries of concern
Definitions of important concepts
Definition of an infectious disease/infection
Definitions of epidemiological roles
Review of some infectious diseases already reported in European wild ungulates
Risks factors associated with the transmission of diseases
Global level (national or European level)
Distribution of gerographical spaces
Global agricultural practices
Microbial evolution and adaptation
Global increased mobility and trade
Local level (regional or district)
Natural dynamics of wildlife populations
At European level
Biodiversity and wild heritage
Role of biodiversity in disease ecology
OIE working group on wildlife diseases
Prioritisation of wildlife diseases
At country level
At local level
Adaptation of livestock farming
Specific hunting measures
1.1. General introduction
The transmission of infectious diseases between wild and domestic animals is becoming an issue of major interest . Scientists still lack of knowledge concerning the means and ways a large majority of infectious agents are transmitted. Wildlife can be exposed to domestic animal diseases resulting in severe consequences on their populations. On the other hand, numerous emerging infectious diseases (EIDs), including zoonoses, were shown to originate from wildlife [2, 3]. Multiple publications dealing with wildlife diseases focus on zoonoses, while the present review targets the wild ungulates present in Europe (focussing on suinae and ruminants ), considering their close ecological and phylogenic relationship with livestock. The main objectives of this review are (i) for the first time, to establish a list as complete as possible of infectious agents already reported in European wild ungulates, (ii) to evaluate the possible role of both wild and domestic ungulates in the transmission of infectious diseases and (iii) to emphasize the importance of considering wildlife when studying the epidemiology of infectious diseases. Indeed, wild species may be infected by livestock pathogens and, at the same time, be a risk for the re-infection of livestock . Thus, their importance in global animal health and in farming economy must be taken into account. This review is the first to list so exhaustively infectious diseases/infections already reported in European wild ungulates and, above all, to address their potential epidemiological role (e.g. reservoir, spillover, dead-end host and asymptomatic excretory animal). Bacterial, viral and prion, parasitic diseases are listed in three additional files (additional file 1, additional file 2 and additional file 3). In order to better understand the epidemiology of diseases/infections at the domestic animals/wildlife interface, global risk factors associated with the transmission of infectious diseases are reviewed. Finally, the different measures implemented by European countries regarding wildlife diseases/infections are summarized and new areas of research are suggested.
1.2. Methodology of bibliographic research
A list of bacterial, viral and parasitic diseases known to affect wild ungulates or livestock in Europe was established. The starting point was the list of diseases reportable to the World Organization for Animal Health (OIE). A bibliographical research was performed, combining the [name of pathogens] or the [name of the disease associated] with [ungulate] or [wildlife] or [wild ungulate] on web medical servers and databases (Medline, PubMed, CAB abstracts and ISI Web of Knowledge). Researches on prevalence or seroprevalence studies were mostly carried out from October 2008 to March 2009. No time limits of publication were imposed. For each pathogen, the most recent publications covering a maximum of European countries were selected. Furthermore, for each risk factor or perspective considered, a bibliographic review was launched in both Pubmed and ISI Web of Knowledge databases to identify the most suitable publications (fitting with keywords introduced, and illustrating problematic of concerns).
2. Current situation/status of European wild ungulates
2.1. Species and countries of concerns
This review targets wild ungulates present in the European continent (not only the European Union). They are listed in Table 1 according to their phylogenic relationship. Data about the origin of populations (natural vs. introduced) as well as their geographical distribution are adapted from a recently edited book .
2.2. Definition of important concepts
2.2.1. Definition of an infectious disease/infection
The definition of an infectious disease/infection is the first step towards understanding the mechanisms involved in the transmission of a pathogen between animals. The first definition was given by Koch in four postulates at the end of the 19th century. However, they are stated in a "one disease-one agent" model and are almost exclusively based on laboratory considerations. Several characteristics such as carrier state, opportunistic agents or predisposing factors are not taken into account with this definition. A disease may be currently defined as "any perturbation, not balanced, of one or more body function(s)" , which includes responses to infectious as well as non infectious agents . In wild animals, characterized by feeding, reproduction and movements mostly independent from human activities (in opposition to domestic animals) , disease is strongly associated with environmental factors. Ecological factors are of major importance in the dynamics of wild populations as their survival rate and fecundity may be influenced by diseases . A new concept of disease ecology recently emerged. For a well defined target population, the study of a disease/infection should be related to the study of interactions between the environment, pathogens and human activities [1, 10]. For practical reasons, in this review, the term disease will be used to design both disease and infection.
2.2.2. Definitions of epidemiological roles
Studying and controlling an infectious disease implies the knowledge of all actors involved in its transmission. A reservoir, or maintenance host, "is able to maintain an infection in a given area, in the absence of cross-contamination from other domestic or wild animals" . Some authors distinguish different types of reservoirs (1) true reservoir (the species alone maintains the infection), (2) accessory reservoir (maintains the infection secondarily to the main reservoir), (3) opportunistic reservoir (accidentally infected, but without serious consequences) and (4) potential reservoir (can be a reservoir for biological or ecological reasons, but, to date, has not been identified as such under field conditions) . For each category, the reservoir is related to a target population . Spillover hosts can maintain the infection after recurrent contacts with an external source . However, the categorisation of a species is not definite and may be a question of time: the integration in the maintenance or spillover categories of hosts is dynamic as a spillover species may become a reservoir as suspected in the French Brotonne forest: cervids were initially spillover hosts for Mycobacterium bovis but because of a high density of animals, the infection spread among them and they now act like maintenance hosts . Wildlife pathogens can also spill back to domestic animals . A dead-end host may be infected by a pathogen but does not allow its transmission in natural conditions; such status may be lost by a species under modified environmental conditions . Finally, an infected animal can excrete a pathogen without showing obvious clinical signs. It is important to mention that the environmental survival of pathogens may also determine wether or not an asymptomatic excretory animal may be considered as reservoir.
Although definitions seem to be clearly delimited, it is not so easy to determine the particular role of a species. Indeed, out of 295 descriptions of wildlife infections reported in the additional files, their epidemiological role is only suggested by the authors in 34.2% of cases (N = 101). Authors often lack of data concerning species interactions as well as the infection status in other species. Besides, to determine the epidemiological role of a wild species towards domestic animals, it is required to assess the real status of livestock, which might not be always the case .
2.3. Review of some infectious diseases already reported in European wild ungulates
A global view of infectious diseases affecting domestic animals but already reported in European wild ungulates is presented in additional file 1 (bacteria), additional file 2 (viruses and prions) and additional file 3 (parasites). The epidemiological role of each species with respect to the pathological agent is specified. Nevertheless, it is not an exhaustive list of all diseases affecting wild ungulates as these studies only focused on pathogens affecting domestic animals. Pathogens were generally characterized by laboratory tests developed for domestic livestock. Some results such as apparent prevalence may therefore be biased . In addition, the achievement of studies will also largely depend on the geographical accessibility of the region .
3. Risks factors associated with the transmission of diseases
A wide range of factors related to the ecology of diseases, e.g. environmental and ecological parameters, are constantly changing and will subsequently induce modifications in the transmission of pathogens. According to the OIE Terrestrial Animal Health Code, an EID is "a new infection resulting from the evolution or change of an existing pathogenic agent, a known infection spreading to a new geographic area or population, or a previously unrecognised pathogenic agent or disease diagnosed for the first time and which has a significant impact on animal or public health" . Approximately 75% of the pathogens having affected or affecting humans for the last 20 years originate from animals . Moreover, 72% of human EIDs reported between 1940 and 2004 find their origin in wildlife . The role of wild ungulates as a reservoir of infectious diseases, for both humans and livestock, is now well established . Over 250 species of human pathogens have been isolated from ungulates . The main factors affecting the transmission of pathogens among populations of wild ungulates are listed hereafter. Factors related to the host, the pathogen and the environmental changes are considered separately . Most environmental modifications are anthropogenic because directly or indirectly linked to human activities, thus, they are expected to change with time . A spatial classification (local vs. global) of the main factors involved in the transmission of pathogens between wild and domestic ungulates are illustrated in Figure 1.
3.1. Global level (national or European level)
3.1.1. Environmental changes
220.127.116.11. Distribution of geographical spaces
Different factors can explain the constantly increasing interactions between wild and domestic animals. A major parameter is the growing human population, which increased four times during the previous century to now reach 6.9 billion people . Such human population involves a huge and diversified protein demand constantly increasing . In most European countries, large populations of wild ungulates are concentrated in small delimited areas because of high human distribution and densities. Degradation and fragmentation of wild spaces are the main anthropogenic factors associated with the emergence of diseases in wildlife [10, 24]. The Food and Agricultural Organization (FAO) website  provides surface areas of the different type of land cover (agricultural, forestry, crops, meadows, etc.) since 1961 for almost all European countries: their evolution rates in Europe are summarized in Table 2. Until the nineties, areas dedicated to permanent crops and permanent pastures were increasing, leading to a diminution of natural landscape available for wild animals. However, a recent increase in forests areas as well as a global reduction of agricultural areas are observed, reflecting a decreasing importance of agriculture in the economy and additional space for wild populations (positive for wildlife conservation). What will be the real impact on the transmission on infectious diseases between wild animals is still to be assessed.
18.104.22.168. Chemical pollution
Chemical pollution may have a negative impact on wildlife demography or disease susceptibility. Direct impact on reproductive parameters and sex ration has been described . Immunodepression can directly result from a toxic accumulation of chemicals at subclinical levels and increase the susceptibility to infectious diseases . Several studies targeting the consequences of chemical pollution on wildlife reported a direct negative impact on birds and rodents but only few studies focused on wild ungulates . In France, wildlife intoxication reports are registered by the SAGIR Network, in charge of the wildlife health surveillance . Twenty five percent of mammalian intoxication reports concerned ungulates, but only 2.1% of cases were confirmed by positive findings . Scientists reported a biomagnification of chemical concentrations via a food-chain transfer: for instance, liver concentrations of chlordecone, a carcinogenic insecticide, were lower in herbivores (bottom of the food chain) than in carnivores, and concentrations in scavengers were still more elevated (top of the food chain) . The season of sampling should be considered whenever using wildlife as an accumulative bioindicator of environmental pollution. Indeed, seasonal variability in metal levels measured in roe deer kidneys found its origin in the difference of nutrition, both quantitative and qualitative. Seasonal peaks for the majority of metals are observed in a very narrow period (summer-autumn). Some plant taxons, such as fungi, are an important pathway for heavy metal intake into the mammalian organism . In addition, consequences and interactions of chemicals on the expression of a disease are not entirely elucidated yet.
3.1.2. Global agricultural practices
The last century was marked by an evolution of agricultural practices especially through industrialisation. Until the nineties, populations of "European classic livestock species" (cattle, sheep, goat, pig) were globally increasing (Table 3), along with an increase of areas dedicated to farming (Table 2). In such systems, domestic animals were genetically selected for a specific production, and as a result, they are less hardy and resistant to a high exposure rate of pathogens. However, since a few years, everywhere in Europe, public opinion is getting worried about the environment: people are in favour of an agriculture respectful of the environment. Development of organic farming is thus gaining much interest: areas dedicated to such farming were occupying more than 6% of the total agricultural areas in 2008 in Europe . In opposite to the global intensification of agricultural practices, extensive farming systems regain interest, facilitating contacts between livestock and wildlife.
3.1.3. Microbial evolution and adaptation
Pathogens lacking intermediate stages such as viruses, bacteria or protozoans are the main recently emerged pathogens of wildlife . Out of 31 pathogens identified as having a real impact on the dynamics of mammals, 41% are viruses . Because of their high mutational rate, RNA viruses are perfect candidates for emergence. However, even if the evolution of pathogens plays a key role in the emergence of diseases, the ecological factors described below also favour their emergence .
3.1.4. Climate change
According to the last report of the Intergovernmental Panel on Climate Change (IPCC), the earth's surface and oceans temperatures are increasing by leading to the constant reduction of land snow cover and the melting of sea ice and glaciers . The global mean surface air temperature increased of an average of 0.75 C since the mid-twentieth century and climate experts expect this increase to continue during the 21th century . As a result, changes in ecosystems are occurring in many parts of the world: the distribution of species and timing of events in some seasonal cycles are affected . In Europe, changes are less obvious than in other sensible parts of the world such as arctic or tropical ecosystems. However, epidemiological cycles are affected since the temperature threshold may modulate the cycle of vector-borne microorganisms . Climate changes might favour the emergence of vector-borne diseases and be responsible of outbreaks of known diseases in regions where they were never reported before. The prevalence and distribution of well-known vector-borne diseases have already increased during the last decade . In the Mediterranean region, bluetongue virus (BTV) recently emerged and became enzootic in livestock . Wild ungulates were proved to be receptive to the virus in all European regions [37, 38]. In southern Spain, BTV antibodies were detected in wild ruminants in areas where no outbreak had been reported in livestock, suggesting their potential role of reservoir for BTV, but this statement requires further confirmation . The distribution of ticks is evolving along with climate changes. Indeed, during the last 20 years, the upper limit of tick distributions shifted from 700-800 m to 1200-1300 m above the sea level . Consequences on wildlife infections were immediate: in 2005, tick-borne babesiosis was reported for the first time in chamois (Rupicapra rupicapra) in Switzerland .
3.1.5. Global increased mobility and trade
The last decades were marked by an increased human and animal mobility as well as a constantly evolving animal trade. The translocation of wild or domestic animals is one of the major factors responsible for the introduction of diseases. The trade of living animals was multiplied by a factor 10 between 1995 and 2005: global imports and exports were respectively 8.8 and 13.5 times more important in 2005 than in 1995 . Transports are often carried out under very poor conditions because animals are piled up and stressed. Their susceptibility to infections increases. Even if it mainly concerns species other than ungulates, wildlife trade is one of the main problems in a potential cross-species transmission of infectious agents . One should also consider (re)introduction of wild animals for hunting purpose when focusing on wildlife trade. The presence in Europe of most non-native species of ungulates may be explained by such practices. It is currently almost impossible to quantify the global wildlife trade as it is mostly illegal. However, the economic impact resulting from outbreaks caused by wildlife trade has globally reached hundreds of billions dollars to date . Spatial mobility of humans was multiplied by more than 1000 since 1800. A 222% increase is expected for the number of passenger per km by 2035 . As the incubation period of most infections exceeds the time necessary to transfer an animal from a country to another , the propagation of pathogens and vectors has reached an unprecedented rate.
3.2. Local level (regional or district)
3.2.1. Natural dynamics of populations
The social organisation of populations impacts the transmission rate of infections: the probability of contacts is higher for gregarious animals than for solitary species. Besides, the reproduction period is characterised by increased contacts between individuals . Furthermore, the exposure to pathogens depends on the presence/absence of migratory flows . European wild ungulates are not migratory animals as such, except reindeer (Rangifer tarandus). Nevertheless, once wild populations colonize and occupy a given area, some animals might later radially disperse to close areas and be at risk for contamination . Natural and artificial barriers are likely to limit animal movements and may thus reduce the transmission of pathogens.
3.2.2. Human behaviours
Contacts between wildlife and livestock are also increasing because behaviours of farmers, hunters, scientists and the general public are changing.
Along with a global change of agricultural practices at the European scale, it is important to consider local agricultural practices. Changes of farmers' behaviours mostly impact contact rates between wild and domestic ungulates. Pastures are places where the transmission rate of infectious diseases is the highest . Farmers' management of pastures are thus of major importance. Some practices such as salt deposits in alpine pastures enhance the risk of indirect transmission of pathogens, like Pasteurella for example . Mountain transhumance (summer moving of domestic flocks to alpine meadows) was initially performed at walking-distance. Nowadays, flocks are moved by cattle-trucks, allowing long-distance transportations of more animals; alpine meadows are overgrazed and the probability of contacts with wildlife increases. Besides, whereas initially created to protect biodiversity, national parks allow domestic flocks to graze inside their central part in some countries, which may have detrimental effects for both sides.
Hunting behaviours may play a major role in the transmission of diseases between or among wild populations. Food supplementation programs implemented to increase the number of hunting bags have drastically disturbed the natural regulation and spatial distribution of populations. Various wild populations, e.g. wild boar  or red deer , are constantly growing. For example, in Wallonia (Belgium), red deer and roe deer populations have increased twofold while wild boar populations have more than tripled between 1980 and 2005 . In some other European areas, populations are overabundant. The hunting of predators led to their extinction and a subsequent imbalance of interactions between species. Offals of dead wild ungulates are generally left in the field, which may reach at the European scale thousands of tons of potentially infected materials in free access to other species. When an infectious disease is prevalent in wild populations, directed shots of sick animals are often applied. However, during a recent outbreak of infectious keratoconjonctivitis in Alpine wild ungulates, such measure seems to have prevented the natural immunisation of populations (Gauthier, personnal communication). A global reduction in hunting pressure may therefore be preferred, especially to protect reproductive adults.
22.214.171.124. General public
For many city dwellers, contacts with nature are limited to controlled areas such as national parks or wildlife game parks. National/regional natural areas are government parks, of which the first objective is to protect natural lands (ecosystems). Wild ungulates may or may not be hunted in function of local legislation. In these opened parks, public frequentation is constantly increasing, as people are in search of a closer contact with nature under protected conditions. The frequency of contacts between wild species and humans increases as a consequence of natural tourism . Wildlife game parks could be associated to 'game zoos': species belonging to the native European wild fauna are parked in closed areas. Densities of populations are often high and animals are frequently translocated between different parks. The high density rate can be implicated in the transmission of diseases . Deer farming is promoted by several European governments like Switzerland . In France, 400 deer farms are inventoried . The proximity of several species (including humans) will subsequently play a key role in the contact rate.
More and more scientific studies focus on monitoring of wild populations. Even if carefully controlled, the intrusions of scientists may be a risk of disease transmission. Even if some introduction programs prevent animal transfers from one region to another, or between different countries, some wounded animals are brought to health cares and released after successful treatment. While it mainly concerns wild species other than ungulates, such practices can also increase the risk of diseases transmission.
4. Control measures of infectious diseases already implemented in European wildlife
The section below develops the measures already implemented or to be implemented by European countries to control the transmission of diseases between wild and domestic animals, at three different levels: (i) European; (ii) national, (iii) regional (local).
4.1. At European level
The continuity between all living beings involved in the transmission of infectious diseases must be treated from an international point of view.
4.1.1. Wildlife-livestock-human continuum
As previously described, the importance of contacts between wildlife, livestock and humans is such that some authors suggested a "wildlife-livestock-human continuum" . In 2008, King suggested to use the term "interdependence" instead of "independence" of these three compartments . As a consequence, a new concept of conservation medicine emerged for the protection of animal, human and ecosystem healths . The main goals are to promote the development of scientific studies for problems occurring at the interface between environmental and health (human and animal) sciences . In this context, studies of the community ecology should be performed, in order to better understand the epidemiological links between all actors of the wildlife-livestock-human-continuum .
4.1.2 Biodiversity and wild heritage
As already mentioned, infectious diseases affecting wildlife have several impacts such as depletion of populations and rare species (on their own or in concert with other factors) but management actions also have an environmental impact . Nevertheless, if diseases are a risk for wildlife conservation, preserving biodiversity helps also avoiding their emergence. For example, the prevalence of vector-borne diseases will decrease if the variety of food sources (native hosts) increases, as the infestation rate within each species will be reduced .
126.96.36.199. Wild mammals
The first modern complete inventory of mammals was established in 1982, with a list of 4 170 species identified (cited in ). The 1993-inventory included 4 629 different species . In 2005, the complete list of mammals indexed 5 416 species the total number being estimated at around 5 500: 99% of mammalian species are thus probably already known . Such increasing number of identified species is due to the separate listing of newly discovered phenotypes and genotyping through molecular biology (taxonomic revision). Two hundred and forty species of Artiodactyla pertaining to 89 genera are described, most of them living in the biodiversity "hot spots" located in Sub-Saharan Africa. European species of Artiodactyla are by contrast less numerous (see Table 1).
188.8.131.52. Domestic species
Through selection, man created numerous breeds of domestic animals, e.g. there are approximately 700 breeds of cattle identified worldwide . Nevertheless, many of them are on the verge of extinction, decreasing the genetic variability of cattle.
184.108.40.206. Role of biodiversity in disease ecology
The influence of human activities on endangered and unmanaged wild fauna is of major concern. Out of 31 cases of disease emergence in wildlife, only 6 were not influenced by humans . Eighty-eight percent of mammals at risk for severe infections and listed by the International Union for Conservation of Nature (IUCN) Red List of Threatened and Endangered Species are carnivores or artiodactyls . Most livestock and companion animals belong to these categories. The degradation of ecosystems, the loss of habitats and diminishing food resources force some species to use alternative alimentary sources . Biodiversity acts as a primordial barrier against infectious pathogens. Besides, anthropogenic factors causing losses of biodiversity increase the risk of disease emergence  by modifying the abundance, the behaviour or the condition of hosts or vectors . It is then crucial to preserve biodiversity in an integrated and sustainable manner .
4.1.3. OIE working group on wildlife diseases
In order to develop specific surveillance guidelines for wildlife diseases, the OIE recently created a Working Group on Wildlife Diseases . It provides information on the wild animal health status, either in the wild or in captivity. Its most important missions are: (i) the elaboration of recommendations and the reviewing process of scientific publications on wildlife diseases; (ii) the implementation of surveillance systems of the wildlife-domestic animals-human continuum and (iii) the control of emerging and re-emerging zoonoses.
4.1.4. Prioritization of wildlife diseases
Based on an OIE imported framework, a method of "rapid risk analysis" was developed in New Zealand with the aim to prioritize pathogens for the wildlife disease surveillance strategy . Authors first listed all wildlife pathogens likely to interfere with animal or human health. They selected the pathogens likely to have a serious impact on wildlife, livestock and/or humans, after consulting experts of each sector. The risk estimate for each pathogen was scored on a semi-quantitative scale (from 1 to 4). The likelihood and consequences of spread were assessed for free-living and captive wildlife, livestock (distinction between consequences on productivity, welfare and trade), humans and companion animals. The risk of introduction in New Zealand was also assessed (scores: 0 or 1). Finally, pathogens were ranked and authors listed the top exotic and endemic dangerous wildlife pathogens for each population of interest (wildlife, domestic animals or human). Summing the risk estimate for each population gave a "total risk estimate" . In Europe, the French agency for food, environmental and occupational health safety (Anses) multidisciplinary working group also elaborated a two-phase risk prioritization method : (i) identification of diseases of which the incidence or geographical distribution could be affected by climate change, (ii) the risk assessment for each disease. Twenty diseases likely to be influenced by climate changes were selected. The authors qualitatively assessed the risk of each disease for its impact on human and animal health and on economy, considering the likelihood of disease evolution and the impact level. Three diseases affecting ungulates were selected for which some measures needed to be implemented (BTV, Rift Valley Fever and African horse sickness).
The prioritisation of diseases is useful to (re)-direct and target funds allocated to diseases surveillance and research. Organisms involved in wildlife conservation will be more inclined to financially support the control of wildlife diseases . However, several current EIDs should in fact be considered as re-emerging . To focus wildlife surveillance on prioritized agents could lead to a reduced vigilance/surveillance of "old" diseases. Their implementation in a global surveillance of wildlife diseases should be conducted carefully.
4.2. At country level
Some decisions will depend on the organization of national governments and bodies in charge of sanitary surveillance.
4.2.1. Surveillance programs
Disease surveillance is defined by the World Health Organization (WHO) as "the ongoing systematic collection, analysis and interpretation of data but also the dissemination of information to the different actors involved in wildlife management" . For the OIE, surveillance is "aimed at demonstrating the absence of disease/infection, determining the occurrence or distribution of disease/infection, while also detecting as early as possible exotic or emerging diseases" . Several European Member States (MSs) have already implemented a health monitoring of their main wild populations. Surveillance systems of wildlife diseases are usually declined in passive surveillance, which consists in reports and necropsies of all animals found dead, and active surveillance, declined as the sampling of some populations in order to assess the (sero)-prevalence of infections. Such systems are now well developed in Belgium , Spain (Gortazar, personal communication), France (SAGIR Network)  and Switzerland (Ryser-Degiorgis, personal communication). A National Health Surveillance Program for cervids (HOP) was implemented in Norway in 2001 . In Sweden, a monitoring of wildlife health exists since 1945 and became an integrated part of the National Environmental Monitoring Programs .
Such systems should be developed at a larger scale. Each State should be able to provide relevant information on the health status of its wild populations. To help other countries developing surveillance systems, it may be interesting to provide guidelines with different modalities in function of the specific epidemiological situation. Standardization of protocols between the different countries would permit a better global and harmonized evaluation of diseases status, and would allow the implementation of an efficient surveillance system. Moreover, the implementation of epidemiological surveillance should be based on both epidemiological (regular collection and analysis of epidemiological information and early warning systems for animal diseases) and ecological monitoring (surveillance of vectors and wild reservoirs) .
4.2.2. Vaccination programs
Several reasons may justify the implementation of vaccination programs in wild animals: (i) conservation of endangered species, (ii) reduction of disease impacts, (iii) protection of human health (zoonotic agents) and (iv) prevention of transmission to domestic animals (and subsequent economic losses) . Besides, vaccination is an alternative to global culling of wild reservoirs. However, it is important to keep in mind the goals of a vaccination programme. Indeed, a safe and effective vaccine can be used in restricted threatened populations and provide expected results. To eliminate a pathogen in a large area or in large populations, vaccination programs may be used in a multiple-hosts system or at a too-large scale and be unsuccessful. The majority of available vaccines have been developed for domestic animals, and their efficacy and safety are in most cases unknown for wildlife. An ideal vaccine for wildlife should be (i) administered per os, (ii) mono-dose (iii) safe for target and non-target species and, if possible, (iv) inexpensive to produce . For example, in Europe, vaccination programs have been implemented in wild boar for classical swine fever (CSF). In France, a quantitative and retrospective study showed that a preventive vaccination (using oral baits) in a determined region improved the control of CSF, but did not eradicate the disease . For multi-hosts pathogens such as Mycobacterium bovis, vaccination programs may be more difficult to implement , the previous identification of reservoir(s) being essential. Vaccination programs against M. bovis were recently started in the UK for badgers  or in Spain for wild boar . In conclusion, vaccination programs can be used in wildlife under specific conditions, especially for small populations or in restricted areas .
4.2.3. Sentinel animals
A sentinel species is an animal/species different from the target animal/species. The use of sentinel animals may be applied in three main situations: when adequate sampling of the target species is difficult (e.g. rare or endangered species), when the sentinel species is more abundant (e.g. use of sentinel chickens instead of wild birds for West Nile virus monitoring) and finally, when the species provides useful information on lower trophic level (e.g. the study of scavengers or carnivores) [8, 80]. The place a species occupies in the food chain determines its probability of contamination . The target and the sentinel population must be epidemiologically linked, at least spatially and the response of sentinel animals against a particular pathogen must be demonstrable . For example, red deer are used as a sentinel species for the surveillance of BTV in Spain .
4.3. At local level (district or region)
(Inter)-national regulations must be implemented at local levels also, involving the participation of local structures, such as farmers groups or hunter organisations.
4.3.1. Adaptation of livestock farming
Wild animals are often considered as reservoir of infectious diseases . However, in many cases, infections originate from domestic animals. For instance, bovine herpesvirus 1 (BoHV-1) can induce a moderate infection in deer, whereas cattle is not at risk for the cervid herpesvirus 1 . Thus, contacts should be limited but, at best, avoided between wild fauna and livestock . In some regions of North America, brucellosis became endemic among wapitis (Cervus elaphus) and bisons (Bison bison). Bisons were infected by cattle around 1900, and the disease became endemic in those wild populations after their release. Although this example concerns non-European wild populations, the measures implemented are interesting to develop in this review. Despite the implementation of feedgrounds and vaccination, habitat improvement and prevention of commingling, livestock still remains infected. Other management options were then proposed: (i) removing cattle from public lands, (ii) developing and implementing brucellosis vaccines more effective for elks and bisons, (iii) managing cattle through vaccination and physical separation from elks and bisons and (iv) using contraceptives in elks to reduce pregnancies and abortions . In the U.S. Sierra Nevada, a model assessing the impact of different management strategies of domestic sheep (grazing allotment closure, grazing time reductions and reduced probability of contact with stray domestic animals) on the transmission of respiratory diseases from domestic herds to endangered bighorn sheep was built . In order to reduce the risk of disease transmission, the best solution was to avoid an overlapping between domestic sheep and bighorn sheep grazing areas.
Such epidemiologic studies show the importance of identifying and assessing the risks in order to implement preventive measures. Efforts should be devoted towards avoiding contacts between wild and domestic animals. Compartmentalisation and zoning are biosecurity measures advised by the OIE Terrestrial animal health code to avoid contacts between domestic and wild animals. However, such measures are often impossible to achieve in field conditions. The total surface area of the European continent occupied by national parks, protected zones where grazing is forbidden, is in fact very limited . Efforts should be devoted to improve biosecurity in farms. In the UK, cattle often contract Mycobacterium bovis tuberculosis in pasture contaminated by badger excreta . In order to reduce the risk of contamination in pasture, different practices such as the presence of ungrazed wildlife strips, and the greater availability, width and continuity of hedgerow may be proposed. The management of grazing has shown to reduce the risk of contamination. Here are other examples of efficient measures: rotational grazing system, off-fencing of setts and latrines, the avoidance of grazing pasture too short, the non-introduction of cattle to recently cut fields, the moving of cattle to fresh pasture in the afternoon and the absence of supplementary feeding on pasture .
4.3.2. Specific hunting measures
While hunters may play an important role in the transmission of diseases, they can also be important for their control. Indeed, most scientific studies dealing with infectious pathogens in wildlife require an effective collaboration with hunters, as sampling is facilitated on carcasses of hunted animals. Such collaborations should be promoted at a larger scale. Besides, the establishment of controlled management plans for different known diseases should be promoted.
Interdisciplinary collaboration is a requisite to the success of management programs. Studies involving biologists, ecologists, veterinarians, epidemiologists and medical doctors should then be promoted. Nevertheless, further research is needed to clearly assess all consequences of the diseases transmitted between wildlife, livestock and humans. A better knowledge of wild populations (size and distribution) of each species should be promoted by applying harmonized methods among the different regions and/or countries. Besides, more studies could be performed in order to understand and analyse the infectious strains circulating among wild animals, but, above all, to compare them to strains circulating among domestic livestock. In most cases, researchers ignore if strains circulating among domestic and wild populations are similar. The epidemiological cycles of infectious diseases in all populations of concern are not well assessed to date. Then, it would be interesting to study methods of space sharing between wild and domestic animals. Costs associated as well as benefits for biodiversity and economical incentives for livestock farming should be evaluated. Because of numerous factors such as globalisation or climate changes, the threat of EIDs is clearly present. The impact of EIDs on economy and public health is not always easily predictable, and should receive more attention, through prioritization procedures for example. Awareness campaigns of politics via a direct estimation of costs generated by EIDs would allow funding research projects for wildlife health surveillance. Ecology and protection of the environment should also be integrated in research programmes without neglecting the surveillance of already known 'old' diseases.
To focus wildlife surveillance on prioritized agents could lead to a reduced vigilance/surveillance of "old" diseases. Their implementation in a global surveillance of wildlife diseases should be conducted carefully. The implementation of surveillance programs and research studies is not achievable without the involvement of local partners. However, the latter often complain about significant discordances between research (most of the time carried out at the European Union level) and field conditions (regional level). Awareness campaigns and a better communication between all sectors would ensure a better involvement of all surveillance actors and thus benefit to the global system. For example, the attribution of definite roles at the different levels would provide a more efficient distribution of work. Furthermore, information provided by the surveillance of wildlife should be available for the whole scientific community, in order to facilitate the development of spatio-temporal epidemiological methodologies to improve and refine it. Such approach would encourage interdisciplinary collaborations by involving all partners. Surveillance programs have already been implemented in wildlife such as the PREDICT project  developed by the Davis University of California: it uses a risk-based approach focused in areas where zoonotic diseases are most likely to emerge and where host species are likely to have significant interaction with domestic animals and high density human populations . This proactive novel approach should be adapted to the specific EU situation. For some domestic species, epidemiologic networks are already in place, such as the RESPE network (Epidemiosurveillance Network of Equine diseases) in France . This network is based on the existence of different specialized networks. It involves owners/farmers, veterinarians and laboratories. The role of each member is well definite, which comes out onto a well-working network. Besides, decisional trees may be suggested to local partners in order to adapt their management of wild populations and surveillance of diseases. These trees may propose different approaches for the populations' management in function of diseases or clinical signs reported. Such trees may simplify the decision making for local partners, when, for example, an epizooty starts in wildlife populations. Management plans will then be adapted more easily and more quickly.
A preliminary stage would be to categorise the diseases according to different parameters such as its mode of transmission, its pathogeny or the type of clinical signs it generates. Demographic specificities of the populations of interest (gregarious vs. solitary) must be taken into account also. According to the category of disease and the type of populations, management plans may be well adapted or not.
In 2004, King  reminded that knowledge and strategy were still missing for the prevention and control of wild animal diseases. Nowadays, governments and scientists become aware of the necessity to provide means for research on wildlife; scientific studies focusing on wildlife ecology as well as surveillance programs are indeed in expansion . Nevertheless, numerous factors influencing the transmission and ecology of diseases reached a threshold without precedent, and are of major concern for the control of wildlife diseases, such as increasing pressure of humans on natural ecosystems and rising interactions between the different species. A better surveillance of wildlife diseases implemented in an integrated system involving international, national and local actors would be of major relevance to understand the origin of diseases and subsequently to control them. Efforts are required to reduce disagreements and misunderstandings between all actors involved in sanitary surveillance of wildlife. The preservation of biodiversity is crucial for diminishing the risk of disease transmission, as well as the improvement of farm biosafety.
Gortázar C, Ferroglio E, Höfle U, Frölich K, Vicente J: Diseases shared between wildlife and livestock: A European perspective. Eur J Wild Res. 2007, 53: 241-256. 10.1007/s10344-007-0098-y.
Cutler SJ, Fooks AR, van der Poel WH: Public health threat of new, reemerging, and neglected zoonoses in the industrialized world. Emerg Infect Dis. 2010, 16: 1-7.
Daszak P, Cunningham AA, Hyatt AD: Emerging infectious diseases of wildlife - threats to biodiversity and human health. Science. 2000, 287: 443-449. 10.1126/science.287.5452.443.
The NCBI Entrez Taxonomy Homepage. [http://www.ncbi.nlm.nih.gov/taxonomy]
Conner MM, Ebinger MR, Blanchong JA, Cross PC: Infectious disease in cervids of North America: data, models, and management challenges. Ann N Y Acad Sci. 2008, 1134: 146-172. 10.1196/annals.1439.005.
Aulagnier S, Haffner P, Mitchell-Jones AJ, Moutou F, Zima J: Guide des Mammifères d'Europe, d'Afrique du Nord et du Moyen-Orient. 2008, Delachaux et Niestlé, (in French)
Toma B, Benet J-J, Dufour B, Eloit M, Moutou F, Sanaa M: Glossaire d'épidémiologie animale. Edited by: Editions du Point Vétérinaire: Maisons-Alfort. 1991, (in French)
Wobeser G: Disease in Wild Animals: Investigation and Management. 2007, Berlin: Spinger-Verlag
Artois M, Caron A, Leighton FA, Bunn C, Vallat B: Wildlife and emerging diseases. Rev Sci Tech. 2006, 25: 897-912. (in French)
Hudson PJ, Rizzoli AP, Grenfell BT, Heesterbeek JAP, Dobson AP: The ecology of wildlife diseases. 2001, Oxford
Naranjo V, Gortázar C, Vicente J, De La Fuente J: Evidence of the role of European wild boar as a reservoir of Mycobacterium tuberculosis complex. Vet Microbiol. 2008, 127: 1-9. 10.1016/j.vetmic.2007.10.002.
Haydon DT, Cleaveland S, Taylor LH, Laurenson MK: Identifying reservoirs of infection: a conceptual and practical challenge. Emerg Infect Dis. 2002, 8: 1468-1473.
Zanella G, Durand B, Hars J, Moutou F, Garin-Bastuji B, Duvauchelle A, Fermé M, Karoui C, Boschiroli ML: Mycobacterium bovis in wildlife in France. J Wildl Dis. 2008, 44: 99-108.
Martin C, Letellier C, Caij B, Gauthier D, Jean N, Shaffii A, Saegerman C: Epidemiology of Pestivirus infection in wild ungulates of the French South Alps. Vet Microbiol. 2011, 147 (3-4): 320-328. 10.1016/j.vetmic.2010.07.010.
Dobson A, Foufopoulos J: Emerging infectious pathogens of wildlife. Philos Trans R Soc B Biol Sci. 2001, 356: 1001-1012. 10.1098/rstb.2001.0900.
Terrestrial Animal Health Code. [http://www.oie.int/fileadmin/Home/eng/Health_standards/tahc/2010/en_glossaire.pdf]
Vallat B: Improving wildlife surveillance for its protection while protecting us from the diseases it transmits. [http://www.oie.int/en/for-the-media/editorials/detail/article/improving-wildlife-surveillance-for-its-protection-while-protecting-us-from-the-diseases-it-transmit/]
Jones KE, Patel NG, Levy MA, Storeygard A, Balk D, Gittleman JL, Daszak P: Global trends in emerging infectious diseases. Nature. 2008, 451: 990-993. 10.1038/nature06536.
Simpson VR: Wild animals as reservoirs of infectious diseases in the UK. Vet J. 2002, 163: 128-146. 10.1053/tvjl.2001.0662.
Woolhouse ME, Gowtage-Sequeria S: Host range and emerging and reemerging pathogens. Emerg Infect Dis. 2005, 11: 1842-1847. 10.3201/eid1112.050997.
Harrus S, Baneth G: Drivers for the emergence and re-emergence of vector-borne protozoal and bacterial diseases. Int J Parasitol. 2005, 35: 1309-1318. 10.1016/j.ijpara.2005.06.005.
Karesh WB, Cook RA, Bennett EL, Newcomb J: Wildlife trade and global disease emergence. Emerg Infect Dis. 2005, 11: 1000-1002.
Acevedo-Whitehouse K, Duffus AL: Effects of environmental change on wildlife health. Philos Trans R Soc B Biol Sci. 2009, 364: 3429-3438. 10.1098/rstb.2009.0128.
Daszak P, Cunningham AA, Hyatt AD: Anthropogenic environmental change and the emergence of infectious diseases in wildlife. Acta Trop. 2001, 78: 103-116. 10.1016/S0001-706X(00)00179-0.
Guitart R, Sachana M, Caloni F, Croubels S, Vandenbroucke V, Berny P: Animal poisoning in Europe. Part 3: Wildlife. Vet J. 2010, 183: 260-265. 10.1016/j.tvjl.2009.03.033.
Lamarque F, Artois M, Berny P, Hatier C: Réseau SAGIR: douze ans de toxicovigilance. Bull Mens Off Nat Chasse. 1999, 246: 18-26. (in French)
Yamamoto JT, Donohoe RM, Fry DM, Golub MS, Donald JM: Environmental estrogens: implications for reproduction in wildlife. Non infectious diseases of wildlife. Edited by: Fairbrother A, Locke LN, Hoff GL. 1996, London: Manson Publishing, 31-51.
Pokorny B, Ribaric-Lasnik C: Seasonal variability of mercury and heavy metals in roe deer (Capreolus capreolus) kidney. Environ Pollut. 2002, 117: 35-46. 10.1016/S0269-7491(01)00161-0.
Pedersen AB, Jones KE, Nunn CL, Altizer S: Infectious diseases and extinction risk in wild mammals. Conserv Biol. 2007, 21: 1269-1279. 10.1111/j.1523-1739.2007.00776.x.
Delecluse P: The origin of climate changes. Rev Sci Tech. 2008, 27: 309-317.
De La Rocque S, Rioux JA, Slingenbergh J: Climate change: effects on animal disease systems and implications for surveillance and control. Rev Sci Tech. 2008, 27: 339-354.
Lovejoy T: Climate change and biodiversity. Rev Sci Tech. 2008, 27: 331-338.
Dufour B, Moutou F, Hattenberger AM, Rodhain F: Global change: impact, management risk approach and health measures - the case of Europe. Rev Sci Tech. 2008, 27: 529-550.
Saegerman C, Berkvens D, Mellor PS: Bluetongue epidemiology in the European Union. Emerg Infect Dis. 2008, 14: 539-544. 10.3201/eid1404.071441.
Linden A, Mousset B, Grégoire F, Hanrez D, Vandenbussche F, Vandemeulebroucke E, Vanbinst T, Verheyden B, De Clercq K: Bluetongue virus antibodies in wild red deer in southern Belgium. Vet Rec. 2008, 162: 459-10.1136/vr.162.14.459-a.
Ruiz-Fons F, Reyes-García AR, Alcaide V, Gortázar C: Spatial and temporal evolution of bluetongue virus in wild ruminants, Spain. Emerg Infect Dis. 2008, 14: 951-953. 10.3201/eid1406.071586.
García I, Napp S, Casal J, Perea A, Allepuz A, Alba A, Carbonero A, Arenas A: Bluetongue epidemiology in wild ruminants from Southern Spain. Eur J Wild Res. 2009, 55: 173-178. 10.1007/s10344-008-0231-6.
Materna J, Daniel M, Metelka L, Harcarik J: The vertical distribution, density and the development of the tick Ixodes ricinus in mountain areas influenced by climate changes (The Krkonose Mts., Czech Republic). Int J Med Microbiol. 2008, 298: 25-37. 10.1016/j.ijmm.2008.05.004.
Hoby S, Robert N, Mathis A, Schmid N, Meli ML, Hofmann-Lehmann R, Lutz H, Deplazes P, Ryser-Degiorgis MP: Babesiosis in free-ranging chamois (Rupicapra r. rupicapra) from Switzerland. Vet Parasitol. 2007, 148: 341-345. 10.1016/j.vetpar.2007.06.035.
Food and Agriculture Organization. Trade. [http://faostat.fao.org/site/604/DesktopDefault.aspx?PageID=604#ancor]
Gómez A, Aguirre AA: Infectious diseases and the illegal wildlife trade. Ann N Y Acad Sci. 2008, 1149: 16-19. 10.1196/annals.1428.046.
Climate Neutral Network. [http://www.unep.org/climatechange/]
King LJ: Maladies zoonotiques émergentes et ré-émergentes: défis et opportunités. Proceedings of the 72° session générale de l'Organisation mondiale de la santé animale. 2004, Paris (in French)
Van Campen H, Rhyan J: The role of wildlife in diseases of cattle. Vet Clin North Am Food Anim Pract. 2010, 26: 147-161. 10.1016/j.cvfa.2009.10.008.
Richomme C, Gauthier D, Fromont E: Contact rates and exposure to inter-species disease transmission in mountain ungulates. Epidemiol Infect. 2006, 134: 21-30. 10.1017/S0950268805004693.
Laddomada A: Incidence and control of CSF in wild boar in Europe. Vet Microbiol. 2000, 73: 121-130. 10.1016/S0378-1135(00)00139-5.
Gortázar C, Acevedo P, Ruiz-Fons F, Vicente J: Disease risks and overabundance of game species. Eur J Wild Res. 2006, 52: 81-87. 10.1007/s10344-005-0022-2.
Dataset of annual estimations of wild species (red deer, roe deer, fallow deer, mouflons, wild boar and foxes). [http://environnement.wallonie.be/cgi/dgrne/plateforme_dgrne/visiteur/v2/frameset.cfm?page=http://environnement.wallonie.be/administration/dnf.htm]
Vistnes I, Nelleman C: The matter of spatial and temporal scales: a review of reindeer and caribou response to human activity. Polar Biol. 2008, 31: 399-407. 10.1007/s00300-007-0377-9.
Audigé L, Wilson PR, Morris RS: Disease and mortality on red deer farms in New Zealand. Vet Rec. 2001, 148: 334-340. 10.1136/vr.148.11.334.
Sieber V, Robert N, Schybli M, Sager H, Miserez R, Engels M, Ryser-Degiorgis MP: Causes of mortality and diseases in farmed deer in Switzerland. Vet Med Int. 2010
Brelurut A, Chardonnet P, Benoît M: Deer farming in mainland France and french overseas territories. Proceedings of the Quatrièmes rencontres autour des recherches sur les ruminants. 1997, Paris
Collinge SK, Ray C: Disease ecology: community structure and pathogen dynamics. 2006, Oxford
King LJ: Understanding the factors of animal disease emergence: a world of one health. Colloquium Belgian Federal Agency for the Safety Food Chain; Brussel. 2008, 15-18.
Ostfeld RS, Meffe GK, Pearl MC: Conservation medicine: the birth of another crisis discipline. Conservation medicine: ecological health in practice. Edited by: Aguirre AA, Ostfeld RS, Tabor GM, House C, Pearl MC. 2002, New-York: Oxford University Press
Plumb G, Babiuk L, Mazet J, Olsen S, Rupprecht C, Pastoret PP, Slate D: Vaccination in conservation medicine. Rev Sci Tech. 2007, 26: 229-241.
Osburn B, Scott C, Gibbs P: One world--one medicine--one health: emerging veterinary challenges and opportunities. Rev Sci Tech. 2009, 28: 481-486.
Lafferty KD: Is disease increasing or decreasing, and does it impact or maintain biodiversity?. J Parasitol. 2003, 89: S101-S105.
Ostfeld RS: Biodiversity loss and the rise of zoonotic pathogens. Clin Microbiol Infect. 2009, 15 (Suppl 1): 40-43. 10.1111/j.1469-0691.2008.02691.x.
Pastoret PP, Moutou F: Invasive species. Part 1: general aspects and biodiversity. Part 2: concrete examples. Rev Sci Tech. 2010, 29: 421-422.
Mammal Species of the World. [http://www.bucknell.edu/msw3/]
Don Wilson E, Reeder Dee Ann M: Mammal species of the world - a Taxonomic and Geographic reference. 2005, Baltimore: The Johns Hopkins University Press
Felius M: Cattle breeds, an encyclopedia. 1995, Doetinchem
Keesing F, Belden LK, Daszak P, Dobson A, Harvell CD, Holt RD, Hudson P, Jolles A, Jones KE, Mitchell CE, Myers SS, Bogich T, Ostfeld RS: Impacts of biodiversity on the emergence and transmission of infectious diseases. Nature. 2010, 468: 647-652. 10.1038/nature09575.
Maillard JC, Gonzalez JP: Biodiversity and emerging diseases. Ann N Y Acad Sci. 2006, 1081: 1-16. 10.1196/annals.1373.001.
Planté C: Current position of the OIE on the approach of emerging animal diseases. Colloquium Belgian Federal Agency for the Safety Food Chain; Brussel. 2008, 11-13.
McKenzie J, Simpson H, Langstaff I: Development of methodology to prioritise wildlife pathogens for surveillance. Prev Vet Med. 2007, 81: 194-210. 10.1016/j.prevetmed.2007.04.003.
De Meneghi D: Wildlife, environment and (re)-emerging zoonoses, with special reference to sylvatic tick-borne zoonoses in North-Western Italy. Ann Ist Super Sanità. 2006, 42: 405-409.
Protocol for the evaluation of epidemiological systems WHA/EMC/DIS/97.2. [http://www.who.int/vaccines-documents/DocsWord/word577.doc]
Animal Health Surveillance. [http://www.oie.int/index.php?id=169&L=0&htmfile=glossaire.htm#sous-chapitre-2]
Lamarque F, Hatier C, Artois M, Berny P, Diedler C: The SAGIR Network, a national network for surveillance of wildlife diseases in France. Epidémiologie et Santé Animale. 2000, 37: 21-30.
Lillehaug A, Bergsjø B, Schau J, Bruheim T, Vikøren T, Handeland K: Campylobacter spp., Salmonella spp., verocytotoxic Escherichia coli, and antibiotic resistance in indicator organisms in wild cervids. Acta Vet Scand. 2005, 46: 23-32. 10.1186/1751-0147-46-23.
Mörner T: The domestic animal/wildlife interface: issues for disease control, conservation, sustainable food production, and emerging diseases. Conference of the Soc Trop Vet Med and Wild Dis Assoc; Pilanesberg National Park. 2001, 34-38.
Corner LA, Murphy D, Gormley E: Mycobacterium bovis Infection in the Eurasian Badger (Meles meles): the disease, pathogenesis, epidemiology and control. J Comp Pathol. 2010, 144: 1-24. 10.1016/j.jcpa.2010.10.003.
Rossi S, Pol F, Forot B, Masse-provin N, Rigaux S, Bronner A, Le Potier MF: Preventive vaccination contributes to control classical swine fever in wild boar (Sus scrofa sp.). Vet Microbiol. 2010, 142: 99-107. 10.1016/j.vetmic.2009.09.050.
Marano N, Rupprecht C, Regnery R: Vaccines for emerging infections. Rev Sci Tech. 2007, 26: 203-215.
Ballesteros C, Vicente J, Morriss G, Jockney I, Rodriguez O, Gortazar C, De La Fuente J: Acceptance and palatability for domesticand wildlife hosts of baits designed to deliver a tuberculosis vaccine to wildboar piglets. Prev Vet Med. 2011, 98: 198-203. 10.1016/j.prevetmed.2010.10.012.
Rizzoli A, Rosa R, Rosso F, Buckley A, Gould E: West Nile virus circulation detected in northern Italy in sentinel chickens. Vector Borne Zoonotic Dis. 2007, 7: 411-417. 10.1089/vbz.2006.0626.
Wobeser G: Disease in Wild Animals: Investigation and Management. 2007, Berlin: Springer
Hallyday JEB, Gjerde B, Robertson L, Vikøren T, Handeland K: A framework for evaluating animals as sentinels for infectious disease surveillance. J R Soc Interface. 2007, 4: 973-984. 10.1098/rsif.2007.0237.
Pastoret PP, Thiry E, Brochier B, Schwers A, Thomas I, Dubuisson J: Maladies de la faune sauvage transmissibles aux animaux domestiques. Rev Sci Tech. 1988, 7: 661-704. (in French)
Kreeger TJ: Brucellosis in wapiti (Cervus elaphus) and bison (Bison bison) in the United States: a classic wildlife-human-livestock problem. 8th Conference of the European Wildlife Disease Association, 2-5 October 2008; Rovinj. 2008, 31-
Clifford DL, Schumaker BA, Stephenson TR, Bleich VC, Cahn ML, Gonzales BJ, Boyce WM, Mazet JAK: Assessing risk at the wildlife-livestock interface: a study of Sierra Nevada bighorn sheep. Biol Conserv. 2009, 142: 2559-2568. 10.1016/j.biocon.2009.06.001.
Hutchings MR, Harris S: Quantifying the risks of TB infection to cattle posed by badger excreta. Epidemiol Infect. 1999, 122: 167-173. 10.1017/S0950268898001897.
Ward AI, Judge J, Delahay RJ: Farm husbandry and badger behaviour: opportunities to manage badger to cattle transmission of Mycobacterium bovis?. Prev Vet Med. 2010, 93: 2-10. 10.1016/j.prevetmed.2009.09.014.
UC Davis School of Vet Med: One Health Institute: PREDICT. [http://www.vetmed.ucdavis.edu/ohi/predict/index.cfm]
Réseau d'Epidemio-Surveillance en Pathologie Equine. [http://www.respe.net/]
De La Fuente J, Ruiz-Fons F, Naranjo V, Torina A, Rodriguez O, Gortázar C: Evidence of Anaplasma infections in European roe deer (Capreolus capreolus) from southern Spain. Res Vet Sci. 2008, 84: 382-386. 10.1016/j.rvsc.2007.05.018.
Adamska M, Skotarczak B: Wild game as a reservoir of Anaplasma phagocytophilum in north-western Poland. Wiad Parazytol. 2007, 53: 103-107.
Carpi G, Bertolotti L, Pecchioli E, Cagnacci F, Rizzoli A: Anaplasma phagocytophilum groEL gene heterogeneity in Ixodes ricinus larvae feeding on roe deer in Northeastern Italy. Vector Borne Zoonotic Dis. 2009, 9: 179-184. 10.1089/vbz.2008.0068.
Petrovec M, Bidovec A, Sumner JW, Nicholson WL, Childs JE, Avsic-Zupanc T: Infection with Anaplasma phagocytophila in cervids from Slovenia: evidence of two genotypic lineages. Wien Klin Wochenschr. 2002, 114: 641-647.
Beninati T, Piccolo G, Rizzoli A, Genchi C, Bandi C: Anaplasmataceae in wild rodents and roe deer from Trento Province (Northern Italy). Eur J Clin Microbiol Infect Dis. 2006, 25: 677-678. 10.1007/s10096-006-0196-x.
Polin H, Hufnagl P, Haunschmid R, Gruber F, Ladurner G: Molecular evidence of Anaplasma phagocytophilum in Ixodes ricinus ticks and wild animals in Austria. J Clin Microbiol. 2004, 42: 2285-2286. 10.1128/JCM.42.5.2285-2286.2004.
Skarphédinsson S, Jensen PM, Kristiansen K: Survey of tickborne infections in Denmark. Emerg Infect Dis. 2005, 11: 1055-1061.
Stuen S, Moum T, Bernhoft A, Vene S: A paretic condition in an Anaplasma phagocytophilum infected roe deer calf. J Wildl Dis. 2006, 42: 170-174.
De La Fuente J, Vicente J, Höfle U, Ruiz-Fons F, Fernádez de Mera IG, Van Den Bussche RA, Kocan KM, Gortázar C: Anaplasma infection in free-ranging Iberian red deer in the region of Castilla-La Mancha, Spain. Vet Microbiol. 2004, 100: 163-173. 10.1016/j.vetmic.2004.02.007.
Grzeszczuk A, Ziarko S, Prokopowicz D, Radziwon PM: Evidence of Anaplasma phagocytophilum infection in European Bisons in the Bialowieza Primeral Forest, Poland. Med Weter. 2004, 60: 600-601.
Ebani VV, Cerri D, Fratini F, Ampola M, Andreani E: Anaplasma phagocytophilum infection in a fallow deer (Dama dama) population in a preserve of central Italy. New Microbiol. 2007, 30: 161-165.
Stoebel K, Schoenberg A, Streich WJ: The seroepidemiology of Lyme borreliosis in zoo animals in Germany. Epidemiol Infect. 2003, 131: 975-983. 10.1017/S0950268803008896.
Al Dahouk S, Nöckler K, Tomaso H, Splettstoesser WD, Jungersen G, Riber U, Petry T, Hoffmann D, Scholz HC, Hensel A, Neubauer H: Seroprevalence of brucellosis, tularemia, and yersiniosis in wild boars (Sus scrofa) from North-Eastern Germany. J Vet Med B. 2005, 52: 444-455. 10.1111/j.1439-0450.2005.00898.x.
Cvetnic Z, Spicic S, Toncic J, Majnaric D, Benic M, Albert D, Thiebaud M, Garin-Bastuji B: Brucella suis infection in domestic pigs and wild boar in Croatia. Rev Sci Tech. 2009, 28: 1057-1067.
Bergagna S, Zoppi S, Ferroglio E, Gobetto M, Dondo A, Di GE, Gennero MS, Grattarola C: Epidemiologic survey for Brucella suis biovar 2 in a wild boar (Sus scrofa) population in northwest Italy. J Wildl Dis. 2009, 45: 1178-1181.
Ferroglio E, Tolari F, Bollo E, Bassano B: Isolation of Brucella melitensis from alpine ibex. J Wildl Dis. 1998, 34: 400-402.
Garin-Bastuji B, Oudar J, Richard Y, Gastellu J: Isolation of Brucella melitensis biovar 3 from a chamois (Rupicapra rupicapra) in the southern French Alps. J Wildl Dis. 1990, 26: 116-118.
Pastoret PP, Thiry E, Brochier B, Schwers A, Thomas I, Dubuisson J: Maladies de la faune sauvage transmissibles aux animaux domestiques. Rev Sci Tech. 1988, 7: 661-704. (in French)
Muñoz PM, Boadella M, Arnal M, de Miguel MJ, Revilla M, Martínez D, Vicente J, Acevedo P, Oleaga A, Ruiz-Fons F, Marín CM, Prieto JM, de la Fuente J, Barral M, Barberán M, de Luco DF, Blasco JM, Gortázar C: Spatial distribution and risk factors of Brucellosis in Iberian wild ungulates. BMC Infect Dis. 2010, 10: 46-10.1186/1471-2334-10-46.
Leuenberger R, Boujon P, Thür B, Miserez R, Garin-Bastuji B, Rüfenacht J, Stärk KD: Prevalence of classical swine fever, Aujeszky's disease and brucellosis in a population of wild boar in Switzerland. Vet Rec. 2007, 160: 362-368. 10.1136/vr.160.11.362.
Montagnaro S, Sasso S, De ML, Longo M, Iovane V, Ghiurmino G, Pisanelli G, Nava D, Baldi L, Pagnini U: Prevalence of antibodies to selected viral and bacterial pathogens in wild boar (Sus scrofa) in Campania Region, Italy. J Wildl Dis. 2010, 46: 316-319.
Blancou J: Serologic testing of wild roe deer (Capreolus capreolus L.) from the Trois Fontaines forest region of eastern France. J Wildl Dis. 1983, 19: 271-273.
Kita J, Anusz K: Serologic survey for bovine pathogens in free-ranging European bison from Poland. J Wildl Dis. 1991, 27: 16-20.
Hotzel H, Berndt A, Melzer F, Sachse K: Occurrence of Chlamydiaceae spp. in a wild boar (Sus scrofa L.) population in Thuringia (Germany). Vet Microbiol. 2004, 103: 121-126. 10.1016/j.vetmic.2004.06.009.
Gaffuri A, Monaci C, Vicari N, Paterlini F, Magnino S: Dectection of Chamydophila pecorum in the lung of an alpine chamois (Rupicapra rupicapra) in Northern Italy. Proceedings of the 8th Conference of the European Wildlife Disease Assciation, 2-5 October 2008; Rovinj. 2008, 60-
Marreros N, Albini S, Hüssy D, Frey CF, Vogt RR, Abril C, Holzwarth N, Borel N, Dittus S, Willisch C, Signer C, Ryser-Degiorgis MP: Serological survey of infectious abortive agents in free-ranging alpine ibex (Capra ibex ibex) in Switzerland. Proceedings of the 8th Conference of the European Wildlife Disease Association, 2-5 October 2008; Rovinj. 2008, 73-
Astobiza I, Barral M, Ruiz-Fons F, Barandika JF, Gerrikagoitia X, Hurtado A, García-Pérez AL: Molecular investigation of the occurrence of Coxiella burnetii in wildlife and ticks in an endemic area. Vet Microbiol. 2011, 147: 190-194. 10.1016/j.vetmic.2010.05.046.
Ruiz-Fons F, Rodríguez O, Torina A, Naranjo V, Gortázar C, De La Fuente J: Prevalence of Coxiella burnetti infection in wild and farmed ungulates. Vet Microbiol. 2008, 126: 282-286. 10.1016/j.vetmic.2007.06.020.
Barrat J, Gerard Y, Schwers A, Thiry E, Dubuisson J, Blancou J: Serological survey in free-living red deer (Cervus elaphus) in France. The management and health of farmed deer. 1988, 123-127.
Szarek J, Rotkiewicz T, Anusz Z, Khan MZ, Chishti MA: Pathomorphological studies in European bison (Bison bonasus Linnaeus, 1758) with seropositive reaction to Coxiella burnetii. J Vet Med B. 1994, 41: 618-624. 10.1111/j.1439-0450.1994.tb00272.x.
García-Sánchez A, Sánchez S, Rubio R, Pereira G, Alonso JM, Hermoso de Mendoza J, Rey J: Presence of Shiga toxin-producing E. coli O157:H7 in a survey of wild artiodactyls. Vet Microbiol. 2007, 121: 373-377. 10.1016/j.vetmic.2006.12.012.
Handeland K, Boye M, Bergsjø B, Bondal H, Isaksen K, Agerholm JS: Digital necrobacillosis in Norwegian wild tundra reindeer (Rangifer tarandus tarandus). J Comp Pathol. 2010, 143: 29-38. 10.1016/j.jcpa.2009.12.018.
Vicente J, Höfle U, Garrido JM, Fernández de Mera IG, Juste R, Barral M, Gortázar C: Wild boar and red deer display high prevalences of tuberculosis-like lesions in Spain. Vet Res. 2006, 37: 107-119. 10.1051/vetres:2005044.
Pavlik I, Machackova M, Yayo Ayele W, Lamka J, Parmova I, Melicharek I, Hanzlikova M, Körmendy B, Nagy G, Cvetnic Z, Ocepek M, Lipiec M: Incidence of bovine tuberculosis in wild and domestic animals other than cattle in six central European countries during 1990-1999. Vet Med Czech. 2002, 47: 122-131.
Gortázar C, Torres MJ, Vicente J, Acevedo P, Reglero M, De La Fuente J, Negro JJ, Aznar-Martín J: Bovine tuberculosis in Doñana Biosphere Reserve: The role of wild ungulates as disease reservoirs in the last Iberian lynx strongholds. PLoS One. 2008, 3: e2776-10.1371/journal.pone.0002776.
Aranaz A, De Juan L, Montero N, Sánchez C, Galka M, Delso C, Alvarez J, Romero B, Bezos J, Vela AI, Briones V, Mateos A, Domínguez L: Bovine tuberculosis (Mycobacterium bovis) in wildlife in Spain. J Clin Microbiol. 2004, 42: 2602-2608. 10.1128/JCM.42.6.2602-2608.2004.
Candela MG, Serrano E, Martinez-Carrasco C, Martín-Atance P, Cubero MJ, Alonso F, León L: Coinfection is an important factor in epidemiological studies: the first serosurvey of the aoudad (Ammotragus lervia). Eur J Clin Microbiol Infect Dis. 2009, 28: 481-489. 10.1007/s10096-008-0654-8.
Tryland M, Mørk T, Ryeng KA, Sorensen KK: Evidence of parapox-, alphaherpes- and pestivirus infections in carcasses of semi-domesticated reindeer (Rangifer tarandus tarandus) from Finnmark, Norway. Rangifer. 2005, 25: 75-83.
Machackova M, Svastova P, Lamka J, Parmova I, Liska V, Smolik J, Fischer OA, Pavlik I: Paratuberculosis in farmed and free-living wild ruminants in the Czech Republic (1999-2001). Vet Microbiol. 2004, 101: 225-234. 10.1016/j.vetmic.2004.04.001.
Carta T, Gortázar C, Vicente J, Reyes-García R, Perez-de-la-Lastra JM, Torres Sanchez MJ, Negro JJ, Aznar-Martin J: Prevalence of Mycobacterium avium paratuberculosis in wild ruminants (Cervus elaphus, Dama dama, Sus scrofa) from Doñana National Park. Proceedings of the 8th Conference of the European Wildlife Disease Association, 2-5 October 2008; Rovinj. 2008, 29-
Reyes-García R, Pérez-de-la-Lastra JM, Vicente J, Ruiz-Fons F, Garrido JM, Gortázar C: Large-scale ELISA testing of Spanish red deer for paratuberculosis. Vet Immunol Immunopathol. 2008, 124: 75-81. 10.1016/j.vetimm.2008.01.032.
Alvarez J, De JL, Briones V, Romero B, Aranaz A, Fernández-Garayzbal JF, Mateos A: Mycobacterium avium subspecies paratuberculosis in fallow deer and wild boar in Spain. Vet Rec. 2005, 156: 212-213.
Marco I, Ruiz M, Juste R, Garrido JM, Lavín S: Paratuberculosis in free-ranging fallow deer in Spain. J Wildl Dis. 2002, 38: 629-632.
Ryser-Degiorgis MP, Bischof DF, Marreros N, Willisch C, Signer C, Filli F, Brosi G, Frey J, Vilei EM: Detection of Mycoplasma conjunctivae in the eyes of healthy, free-ranging Alpine ibex: possible involvement of Alpine ibex as carriers for the main causing agent of infectious keratoconjunctivitis in wild Caprinae. Vet Microbiol. 2009, 134: 368-374. 10.1016/j.vetmic.2008.08.005.
Verbisck-Bucker G, González-Candela M, Galián J, Cubero-Pablo MJ, Martín-Atance P, León-Vizcaíno L: Epidemiology of Mycoplasma agalactiae infection in free-ranging Spanish ibex (Capra pyrenaica) in Andalusia, southern Spain. J Wildl Dis. 2008, 44: 369-380.
Hoelzle K, Engels M, Kramer MM, Wittenbrink MM, Dieckmann SM, Hoelzle LE: Occurrence of Mycoplasma suis in wild boars (Sus scrofa L.). Vet Microbiol. 2010, 143: 405-409. 10.1016/j.vetmic.2009.11.015.
Sibila M, Mentaberre G, Boadella M, Huerta E, Casas-Díaz E, Vicente J, Gortázar C, Marco I, Lavín S, Segalés J: Serological, pathological and polymerase chain reaction studies on Mycoplasma hyopneumoniae infection in the wild boar. Vet Microbiol. 2010, 144: 214-218. 10.1016/j.vetmic.2009.12.019.
Ytrehus B, Bretten T, Bergsjø B, Isaksen K: Fatal pneumonia epizootic in musk ox (Ovibos moschatus) in a period of extraordinary weather conditions. Ecohealth. 2008, 5: 213-223. 10.1007/s10393-008-0166-0.
Müller T, Teuffert J, Ziedler K, Possardt C, Kramer M, Staubach C, Conraths FJ: Pseudorabies in the European wild boar from eastern Germany. J Wildl Dis. 1998, 34: 251-258.
Gortázar C, Vicente J, Fierro Y, Léon L, Cubero MJ, González M: Natural Aujeszky's disease in a Spanish wild boar population. Ann N Y Acad Sci. 2002, 969: 210-212. 10.1111/j.1749-6632.2002.tb04380.x.
Sedlak K, Bartova E, Machova J: Antibodies to selected viral disease agents in wild boars from the Czech Republic. J Wildl Dis. 2008, 44: 777-780.
Lutz W, Junghans D, Schmitz D, Moller T: A long-term survey of pseudorabies virus infections in European wild boar of western Germany. Z Jagdwiss. 2003, 49: 130-140. 10.1007/BF02190453.
Ruiz-Fons F, Vidal D, Höfle U, Vicente J, Gortázar C: Aujeszky's disease virus infection patterns in European wild boar. Vet Microbiol. 2007, 120: 241-250. 10.1016/j.vetmic.2006.11.003.
Vengust G, Valencak Z, Bidovec A: Presence of antibodies against Aujeszky's disease virus in wild boar (Sus scrofa) in Slovenia. J Wildl Dis. 2005, 41: 800-802.
Lari A, Lorenzi D, Nigrelli D, Brocchi E, Faccini S, Poli A: Pseudorabies virus in European wild boar from central Italy. J Wildl Dis. 2006, 42: 319-324.
Vicente J, Ruiz-Fons F, Vidal D, Höfle U, Acevedo P, Villanúa D, Fernández de Mera IG, Martín MP, Gortázar C: Serosurvey of Aujeszky's disease virus infection in European wild boar in Spain. Vet Rec. 2005, 156: 408-412.
Lelesius R, Sereika V, Zienius D, Michalskiene I: Serosurvey of wild boar population for porcine parvovirus and other selected infectious diseases in Lithuania. Bull Vet Inst Pulawy. 2006, 50: 143-147.
Albina E, Mesplède A, Chenut G, Potier MFl, Bourbao G, Gal Sl, Leforban Y: A serological survey on classical swine fever (CSF), Aujeszky's disease (AD) and porcine reproductive and respiratory syndrome (PRRS) virus infections in French wild boars from 1991 to 1998. Vet Microbiol. 2000, 77: 43-57. 10.1016/S0378-1135(00)00255-8.
Zupancic Z, Jukic B, Lojkic M, Cac Z, Jemersic L, Staresina V: Prevalence of antibodies to classical swine fever, Aujeszky's disease, porcine reproductive and respiratory syndrome, and bovine viral diarrhoea viruses in wild boars in Croatia. J Vet Med B. 2002, 49: 253-256. 10.1046/j.1439-0450.2002.00562.x.
Pérez J, Fernández AI, Sierra MA, Herráez P, Fernández A, Martín de las MJ: Serological and immunohistochemical study of African swine fever in wild boar in Spain. Vet Rec. 1998, 143: 136-139. 10.1136/vr.143.5.136.
Pioz M, Loison A, Gibert P, Dubray D, Menaut P, Le Tallec B, Artois M, Gilot-Fromont E: Transmission of a pestivirus infection in a population of Pyrenean chamois. Vet Microbiol. 2007, 119: 19-30. 10.1016/j.vetmic.2006.09.001.
Marco I, Rosell R, Cabezon O, Mentaberre G, Casas E, Velarde R, Lopez-Olvera JR, Hurtado A, Lavín S: Epidemiological study of border disease virus infection in Southern chamois (Rupicapra pyrenaica) after an outbreak of disease in the Pyrenees (NE Spain). Vet Microbiol. 2008, 127: 29-38. 10.1016/j.vetmic.2007.08.015.
Lillehaug A, Vikøren T, Larsen IL, A.kerstedt J, Tharaldsen J, Handeland K: Antibodies to ruminant alpha-herpesviruses and pestiviruses in Norwegian cervids. J Wildl Dis. 2003, 39: 779-786.
Frölich K, Hamblin C, Parida S, Tuppurainen E, Schettler E: Serological survey for potential disease agents of free-ranging cervids in six selected national parks from Germany. J Wildl Dis. 2006, 42: 836-843.
Gentile L, Mari F, Cardeti G, Macri G: Serologic survey in a chamois population of Abruzzo. Hystrix. 2000, 11: 115-119.
Fernández-Pacheco p, Fernández-Pinero J, Agüero M, Jiménez-Clavero MA: Bluetongue virus serotype 1 in wild mouflons in Spain. Vet Rec. 2008, 162: 659-660. 10.1136/vr.162.20.659.
Henrich M, Reinacher M, Hamann HP: Lethal bluetongue virus infection in an alpaca. Vet Rec. 2007, 161: 764-10.1136/vr.161.22.764.
Frölich K: Bovine virus diarrhea and mucosal disease in free-ranging and captive deer (Cervidae) in Germany. J Wildl Dis. 1995, 31: 247-250.
Nielsen SS, Roensholt L, Bitsch V: Bovine virus diarrhea virus in free-living deer from Denmark. J Wildl Dis. 2000, 36: 584-587.
Pol F, Rossi S, Mesplède A, Kuntz-Simon G, Le Potier MF: Two outbreaks of classical swine fever in wild boar in France. Vet Rec. 2008, 162: 811-816. 10.1136/vr.162.25.811.
Meloni D, Maurella C, Carnieri L, Cavarretta M, Orusa R, Cocco C, Ru G, Bozzetta E: Results of a survey for chronic wasting disease in Italian cervids. Proceedings of the 8th Conference of the European Wildlife Disease Association, 2-5 October 2008; Rovinj. 2008, 75-
Roels S, Saegerman C, De Bosschere H, Berkvens D, Gregoire F, Hoyoux A, Mousset B, Desmecht D, Vanopdenbosch E, Linden A: First results of chronic wasting disease (CWD) surveillance in the south-eastern part of Belgium. Vet Q. 2005, 27: 98-104. 10.1080/01652176.2005.9695190.
Billinis C: Encephalomyocarditis virus infection in wildlife species in Greece. J Wildl Dis. 2009, 45: 522-526.
Elbers ARW, Dekker A, Dekkers LJM: Serosurveillance of wild deer and wild boar after the epidemic of foot-and-mouth disease in the Netherlands in 2001. Vet Rec. 2003, 153: 678-681. 10.1136/vr.153.22.678.
Boadella M, Carrasco R, Bibiana P, Segalés J, Gortázar C: Seroprevalence of Hepatitis E virus in European wild boars (Sus scrofa) from different areas of Spain. Proceedings of the 3rd European Wildlife Disease Association Student Workshop, 19-22 March 2009; Veyrier-du-Lac. 2009, 45-
Reuter G, Fodor D, Forgach P, Kátai A, Szucs G: Characterization and zoonotic potential of endemic hepatitis E virus (HEV) strains in humans and animals in Hungary. J Clin Microbiol. 2009, 44: 277-281.
Rutjes SA, Lodder-Verschoor F, Lodder WJ, van der Giessen J, Reesink H, Bouwknegt M, de Roda Husman AM: Seroprevalence and molecular detection of hepatitis E virus in wild boar and red deer in The Netherlands. J Virol Meth. 2010, 168: 197-206. 10.1016/j.jviromet.2010.05.014.
Vikøren T, Lillehaug A, Akerstedt J, Bretten T, Haugum M, Tryland M: A severe outbreak of contagious ecthyma (orf) in a free-ranging musk ox (Ovibos moschatus) population in Norway. Vet Microbiol. 2008, 127: 10-20. 10.1016/j.vetmic.2007.07.029.
Reiner G, Bronnert B, Hohloch C, Reinacher M, Willems H: Distribution of ORF2 and ORF3 genotypes of porcine circovirus type 2 (PCV-2) in wild boars and domestic pigs in Germany. Vet Microbiol. 2011, 148: 372-376. 10.1016/j.vetmic.2010.08.017.
Vicente J, Segalés J, Höfle U, Balasch M, Plana-Duran J, Domingo M, Gortázar C: Epidemiological study on porcine circovirus type 2 (PCV2) infection in the European wild boar (Sus scrofa). Vet Res. 2004, 35: 243-253. 10.1051/vetres:2004008.
Olde Riekerink RG, Dominici A, Barkema HW, de Smit AJ: Seroprevalence of pestivirus in four species of alpine wild ungulates in the High Valley of Susa, Italy. Vet Microbiol. 2005, 108: 297-303. 10.1016/j.vetmic.2005.04.014.
Erhouma E, Guiguen F, Chebloune Y, Gauthier D, Lakhal LM, Greenland T, Mornex JF, Leroux C, Alogninouwa T: Small ruminant lentivirus proviral sequences from wild ibexes in contact with domestic goats. J Gen Virol. 2008, 89: 1478-1484. 10.1099/vir.0.2008/000364-0.
Hoby S, Mathis A, Doherr MG, Robert N, Ryser-Degiorgis MP: Babesia capreoli infections in alpine chamois (Rupicapra r. Rupicapra), roe deer (Capreolus c. Capreolus) and red deer (Cervus elaphus) from Switzerland. J Wildl Dis. 2009, 45: 748-753.
García-Sanmartín J, Aurtenetxe O, Barral M, Marco I, Lavín S, García-Pérez AL, Hurtado A: Molecular detection and characterization of piroplasms infecting cervids and chamois in Northern Spain. Parasitology. 2007, 134: 391-398. 10.1017/S0031182006001569.
Duh D, Petrovec M, Bidovec A, Avsic-Zupanc T: Cervids as Babesiae hosts, Slovenia. Emerg Infect Dis. 2005, 11: 1121-1123.
Ferrer D, Castellá J, Gutiérrez JF, Lavín S, Marco I: Seroprevalence of Babesia ovis in mouflon sheep in Spain. J Wildl Dis. 1998, 34: 637-639.
Ferrer D, Castellá J, Gutiérrez JF, Lavín S, Marco I: Seroprevalence of Babesia ovis in Spanish ibex (Capra pyrenaica) in Catalonia, northeastern Spain. Vet Parasitol. 1998, 75: 93-98. 10.1016/S0304-4017(97)00199-4.
Marco I, Velarde R, Castellá J, Ferrer D, Lavín S: Presumptive Babesia ovis infection in a spanish ibex (Capra pyrenaica). Vet Parasitol. 2000, 87: 217-221. 10.1016/S0304-4017(99)00170-3.
Paziewska A, Bednarska M, Nieweglowski H, Karbowiak G, Bajer A: Distribution of Cryptosporidium and Giardia spp. in selected species of protected and game mammals from North-Eastern Poland. Ann Agric Environ Med. 2007, 14: 265-270.
Hamnes IS, Gjerde B, Robertson L, Vikøren T, Handeland K: Prevalence of Cryptosporidium and Giardia in free-ranging wild cervids in Norway. Vet Parasitol. 2006, 141: 30-41. 10.1016/j.vetpar.2006.05.004.
Sturdee AP, Chalmers RM, Bull SA: Detection of Cryptosporidium oocysts in wild mammals of mainland Britain. Vet Parasitol. 1999, 80: 273-280. 10.1016/S0304-4017(98)00226-X.
Shimalov VV, Shimalov VT: Helminth fauna of cervids in Belorussian Polesie. Parasitol Res. 2003, 89: 75-76. 10.1645/0022-3395(2003)089[0075:BR]2.0.CO;2.
Beck R, Maringulic A, Lucinger S, Tonanzi D, Pozio E, Caccio SM: Prevalence and molecular characterization of Giardia isolates from wild mammals. Proceedings of the 8th Conference of the European Wildlife Disease Association, 2-5 October 2008; Rovinj. 2008, 13-
Bastian S, Brisseau N, Jouglin M, Klegou G, alandrin L, hostis M, hauvin A: Seroprevalence of Babesia species infecting roe deer (Capreolus capreolus). Proceedings of the 8th Conference of the European Wildlife Disease Association, 2-5 October 2008; Rovinj. 2008, 43-
Lebbad M, Mattsson JG, Christensson B, Ljungström B, Backhans A, Andersson JO, Svärd SG: From mouse to moose: multilocus genotyping of Giardia isolates from various animal species. Vet Parasitol. 2010, 168: 231-239. 10.1016/j.vetpar.2009.11.003.
Almería S, Vidal D, Ferrer D, Pabón M, Fernández de Mera IG, Ruiz-Fons F, Alzaga V, Marco I, Calvete C, Lavín S, Gortázar C, López-Gatius F, Dubey JP: Seroprevalence of Neospora caninum in non-carnivorous wildlife from Spain. Vet Parasitol. 2007, 143: 21-28. 10.1016/j.vetpar.2006.07.027.
Bártová E, Sedlák K, Literák I: Prevalence of Toxoplasma gondii and Neospora caninum antibodies in wild boars in the Czech Republic. Vet Parasitol. 2006, 142: 150-153. 10.1016/j.vetpar.2006.06.022.
Vikøren T, Tharaldsen J, Fredriksen B, Handeland K: Prevalence of Toxoplasma gondii antibodies in wild red deer, roe deer, moose, and reindeer from Norway. Vet Parasitol. 2004, 120: 159-169. 10.1016/j.vetpar.2003.12.015.
Gauss CB, Dubey JP, Vidal D, Cabezón O, Ruiz-Fons F, Vicente J, Marco I, Lavín S, Gortázar C, Almería S: Prevalence of Toxoplasma gondii antibodies in red deer (Cervus elaphus) and other wild ruminants from Spain. Vet Parasitol. 2006, 136: 193-200. 10.1016/j.vetpar.2005.11.013.
Masoero L, Guglielmetti C, Pitti M, De Marco L, Ferroglio E, Gennero S: Serological monitoring of mouflon (Ovis orientalis musimon) in the archipelago Toscano National Park, Italy. Proceedings of the 8th Conference of the European Wildlife Disease Association, 2-5 October 2008; Rovinj. 2008, 74-
Richomme C, Aubert D, Gilot-Fromont E, Ajzenberg D, Mercier A, Ducrot C, Ferte H, Delorme D, Villena I: Genetic characterization of Toxoplasma gondii from wild boar (Sus scrofa) in France. Vet Parasitol. 2009, 164: 296-300. 10.1016/j.vetpar.2009.06.014.
Rossi L, Fraquelli C, Vesco U, Permunian R, Sommavilla G, Carmignola G, Da Pozzo R, Meneguz P: Descriptive epidemiology of a scabies epidemic in chamois in the Dolomite Alps, Italy. Eur J Wild Res. 2007, 53: 131-141. 10.1007/s10344-006-0067-x.
Fernández-Moran J, Gomez S, Ballesteros F, Quiros PQ, Benito JL, Feliu C, Nieto JM: Epizootiology of sarcoptic mange in a population of cantabrian chamois (Rupicapra pyrenaica parva) in Northwestern Spain. Vet Parasitol. 1997, 73: 163-171. 10.1016/S0304-4017(97)00061-7.
Alasaad S, Granados JE, Cano-Manuel FJ, Meana A, Zhu XQ, Pérez JM: Epidemiology of fasciolosis affecting Iberian ibex (Capra pyrenaica) in southern Spain. Parasitol Res. 2008, 102: 751-755. 10.1007/s00436-007-0830-2.
León-Vizcaíno L, Ruíz de Ybañez MR, Cubero MJ, Ortíz JM, Espinosa J, Pérez L, Simón MA, Alonso F: Sarcoptic mange in Spanish ibex from Spain. J Wildl Dis. 1999, 35: 647-659.
Rossi L, Meneguz PG, De MP, Rodolfi M: The epizootiology of sarcoptic mange in chamois, Rupicapra rupicapra, from the Italian eastern Alps. Parassitologia. 1995, 37: 233-240.
La grande douve du foie (Fasciola hepatica): quelques notions. (in French), [http://www.oncfs.gouv.fr/IMG/Lettre%20SAGIR%20159.pdf]
Beck A, Beck R, Vrkic V, Conrado Sostaric Zuckerman I, Hohsteter M, Artukovic B, Janicki Z, Konjevic D, Maringulic A, Grabarevic Z: Red deer (Cervus elaphus) are not a perfect host for Fascioloides magna: evidence from a histopathological study. Proceedings of the 8th Conference of the European Wildlife Disease Association, 2-5 October 2008; Rovinj. 2008, 45-
Antolová D, Reiterová K, Dubinsky P: The role of wild boar (Sus scrofa) in circulation of trichinellosis, toxocarosis and ascariosis in the Slovak Republik. Helminthology. 2006, 43: 92-97. 10.2478/s11687-006-0018-9.
Richomme C, Lacour SA, Ducrot C, Gilot-Fromont E, Casabianca F, Maestrini O, Vallée I, Grasset A, van der Giessen J, Boireau P: Epidemiological survey of trichinellosis in wild boar (Sus scrofa) and fox (Vulpes vulpes) in a French insular region, Corsica. Vet Parasitol. 2010, 172: 150-154. 10.1016/j.vetpar.2010.04.026.
Schynts F, van der Giessen J, Tixhon S, Pozio E, Dorny P, de Borchgrave J: First isolation of Trichinella britovi from a wild boar (Sus scrofa) in Belgium. Vet Parasitol. 2006, 135: 191-194. 10.1016/j.vetpar.2005.09.002.
Blaga R, Gherman C, Cozma V, Zocevic A, Pozio E, Boireau P: Trichinella species circulating among wild and domestic animals in Romania. Vet Parasitol. 2009, 159: 218-221. 10.1016/j.vetpar.2008.10.034.
van der Giessen JW, Rombout Y, van der Veen A, Pozio E: Diagnosis and epidemiology of Trichinella infections in wildlife in The Netherlands. Parasite. 2001, 8: S103-S105.
Dr Claire Martin was funded by a research grant of the University of Liege (Belgium). There are no potential conflicts of interest for any of the authors.
7. Competing interests
The authors declare that they have no competing interests.
8. Authors' contributions
CM and CS participated in the conception and the design of the survey. CM carried out the majority of the bibliographic search and the redaction of the manuscript. PPP and BB revised the manuscript. MFH participated in the English improvement and in the revision of the manuscript. CS participated in the coordination as well as in the revision and commenting of the manuscript. All authors read and approved the final manuscript.
Electronic supplementary material
Additional file 1: [90–137]. Selected bacterial diseases reported in wild ungulates in Europe. This file is a table presenting a list of bacterial diseases already reported in wild ungulates in Europe. (DOC 238 KB)
Additional file 2: [138–171]. Selected viral diseases reported in wild ungulates in Europe. This file is a table presenting a list of viral diseases already reported in wild ungulates in Europe. (DOC 152 KB)
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Martin, C., Pastoret, P., Brochier, B. et al. A survey of the transmission of infectious diseases/infections between wild and domestic ungulates in Europe. Vet Res 42, 70 (2011) doi:10.1186/1297-9716-42-70
- Wild Boar
- West Nile Virus
- Domestic Animal
- Classical Swine Fever