Figure 4
From: Variability in the response of canine and human dendritic cells stimulated with Brucella canis
Different cytokine mRNA expression in whole B. canis -stimulated canine or human DCs. Quantification of the cytokines IL-1β, IL-12p35, IFN-γ, and TNF-α (Th1-type), IL-4, IL-5, and IL-13 (Th2-type), IL-6, IL-17, and IL-23 (Th17-type), and IL-10 and TGF-β1 (T regulatory-type) is represented as mRNA fold-change in DCs stimulated with whole B. canis. Dose-dependent increase in the cytokine mRNA expression when canine DCs were stimulated at MOIs = 2 × 10−1 to 2 × 102 (A). Cytokine mRNA expression in canine (B) and human DCs (C), when cells were stimulated with whole B. canis at a MOI = 2 × 102. The cytokine mRNA expression in non-stimulated DCs was considered as 1, as a reference for fold-change in expression (N.S.). *p < 0.05, **p < 0.01, and ***p < 0.001.