Solano-Gallego L, Koutinas A, Miró G, Cardoso L, Pennisi MG, Ferrer L, Bourdeau P, Oliva G, Baneth G: Directions for the diagnosis, clinical staging, treatment and prevention of canine leishmaniosis. Vet Parasitol. 2009, 165: 1-18.
Article
CAS
PubMed
Google Scholar
Killick-Kendrick R: The biology and control of Phlebotomine sand flies. Clin Dermatol. 1999, 17: 279-289.
Article
CAS
PubMed
Google Scholar
Foglia Manzillo V, Oliva G, Pagano A, Manna L, Maroli M, Gradoni L: Deltamethrin-impregnated collars for the control of canine leishmaniasis: evaluation of the protective effect and influence on the clinical outcome of Leishmania infection in kennelled stray dogs. Vet Parasitol. 2006, 142: 142-145.
Article
CAS
PubMed
Google Scholar
Foglia Manzillo V, Di Muccio T, Cappiello S, Scalone A, Paparcone R, Fiorentino E, Gizzarelli M, Gramiccia M, Gradoni L, Oliva G: Prospective study on the incidence and progression of clinical signs in naïve dogs naturally infected by Leishmania infantum. PLoS Negl Trop Dis. 2013, 7: e2225-
Article
PubMed Central
PubMed
Google Scholar
Cortes S, Vaz Y, Neves R, Maia C, Cardoso L, Campino L: Risk factors for canine leishmaniasis in an endemic Mediterranean region. Vet Parasitol. 2012, 189: 189-196.
Article
PubMed
Google Scholar
Rosypal AC, Troy GC, Zajac AM, Frank G, Lindsay DS: Transplacental transmission of a North American isolate of Leishmania infantum in an experimentally infected beagle. J Parasitol. 2005, 91: 970-972.
Article
PubMed
Google Scholar
Silva FL, Oliveira RG, Silva TMA, Xavier MN, Nascimento EF, Santos RL: Venereal transmission of canine visceral leishmaniasis. Vet Parasitol. 2009, 160: 55-59.
Article
PubMed
Google Scholar
De Freitas E, Melo MN, da Costa-Val AP, Michalick MSM: Transmission of Leishmania infantum via blood transfusion in dogs: potential for infection and importance of clinical factors. Vet Parasitol. 2006, 137: 159-167.
Article
PubMed
Google Scholar
Alvar J, Cañavate C, Molina R, Moreno J, Nieto J: Canine leishmaniasis. Adv Parasitol. 2004, 57: 1-88.
Article
PubMed
Google Scholar
Solano-Gallego L, Morell P, Arboix M, Alberola J, Ferrer L: Prevalence of Leishmania infantum infection in dogs living in an area of canine leishmaniasis endemicity using PCR on several tissues and serology. J Clin Microbiol. 2001, 39: 560-563.
Article
PubMed Central
CAS
PubMed
Google Scholar
Santos-Gomes GM, Rosa R, Leandro C, Cortes S, Romão P, Silveira H: Cytokine expression during the outcome of canine experimental infection by Leishmania infantum. Vet Immunol Immunopathol. 2002, 88: 21-30.
Article
CAS
PubMed
Google Scholar
Carrillo E, Moreno J: Cytokine profiles in canine visceral leishmaniasis. Vet Immunol Immunopathol. 2009, 128: 67-70.
Article
CAS
PubMed
Google Scholar
Bongiorno G, Paparcone R, Foglia Manzillo V, Oliva G, Cuisinier A-M, Gradoni L: Vaccination with LiESP/QA-21 (CaniLeish®) reduces the intensity of infection in Phlebotomus perniciosus fed on Leishmania infantum infected dogs–a preliminary xenodiagnosis study. Vet Parasitol. 2013, 197: 691-695.
Article
CAS
PubMed
Google Scholar
Dye C: The logic of visceral leishmaniasis control. Am J Trop Med Hyg. 1996, 55: 125-130.
CAS
PubMed
Google Scholar
Gramiccia M: Recent advances in leishmaniosis in pet animals: epidemiology, diagnostics and anti-vectorial prophylaxis. Vet Parasitol. 2011, 181: 23-30.
Article
CAS
PubMed
Google Scholar
Borja-Cabrera GP, Correia Pontes NN, da Silva VO, Paraguai de Souza E, Santos WR, Gomes EM, Luz KG, Palatnik M, Palatnik de Sousa CB: Long lasting protection against canine kala-azar using the FML-QuilA saponin vaccine in an endemic area of Brazil (São Gonçalo do Amarante, RN). Vaccine. 2002, 20: 3277-3284.
Article
CAS
PubMed
Google Scholar
Fernandes AP, Costa MMS, Coelho EAF, Michalick MSM, de Freitas E, Melo MN, Luiz Tafuri W, Resende DDM, Hermont V, Abrantes CDF, Gazzinelli RT: Protective immunity against challenge with Leishmania (Leishmania) chagasi in beagle dogs vaccinated with recombinant A2 protein. Vaccine. 2008, 26: 5888-5895.
Article
CAS
PubMed
Google Scholar
Fernandes AP, Coelho EAF, Machado-Coelho GLL, Grimaldi G, Gazzinelli RT: Making an anti-amastigote vaccine for visceral leishmaniasis: rational, update and perspectives. Curr Opin Microbiol. 2012, 15: 476-485.
Article
CAS
PubMed
Google Scholar
Moreno J, Vouldoukis I, Martin V, McGahie D, Cuisinier A-M, Gueguen S: Use of a LiESP/QA-21 vaccine (CaniLeish) stimulates an appropriate Th1-dominated cell-mediated immune response in dogs. PLoS Negl Trop Dis. 2012, 6: e1683-
Article
PubMed Central
CAS
PubMed
Google Scholar
Moreno J, Vouldoukis I, Schreiber P, Martin V, McGahie D, Gueguen S, Cuisinier A-M: Primary vaccination with the LiESP/QA-21 vaccine (CaniLeish®) produces a cell-mediated immune response which is still present 1 year later. Vet Immunol Immunopathol. 2014, 158: 1-9.
Article
Google Scholar
Murray HW, Hariprashad J, Coffman RL: Behavior of visceral Leishmania donovani in an experimentally induced T helper cell 2 (Th2)-associated response model. J Exp Med. 1997, 185: 867-874.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lemesre JL: Patent application No FR2705358A1: Procédé de culture in vitro de différents stades de parasites tissulaires obtenus et applications biologiques. 1993
Google Scholar
Bates PA, Rogers ME: New insights into the developmental biology and transmission mechanisms of Leishmania. Curr Mol Med. 2004, 4: 601-609.
Article
CAS
PubMed
Google Scholar
Mary C, Faraut F, Lascombe L, Dumon H: Quantification of Leishmania infantum DNA by a real-time PCR assay with high sensitivity. J Clin Microbiol. 2004, 42: 5249-5255.
Article
PubMed Central
CAS
PubMed
Google Scholar
Moreno J, Nieto J, Chamizo C, González F, Blanco F, Barker DC, Alvar J: The immune response and PBMC subsets in canine visceral leishmaniasis before, and after, chemotherapy. Vet Immunol Immunopathol. 1999, 71: 181-195.
Article
CAS
PubMed
Google Scholar
Carrillo E, Crusat M, Nieto J, Chicharro C, Thomas Mdel C, Martínez E, Valladares B, Cañavate C, Requena JM, López MC, Alvar J, Moreno J: Immunogenicity of HSP-70, KMP-11 and PFR-2 leishmanial antigens in the experimental model of canine visceral leishmaniasis. Vaccine. 2008, 26: 1902-1911.
Article
CAS
PubMed
Google Scholar
Holzmuller P, Cavaleyra M, Moreaux J, Kovacic R, Vincendeau P, Papierok G, Lemesre J-L: Lymphocytes of dogs immunised with purified excreted-secreted antigens of Leishmania infantum co-incubated with Leishmania infected macrophages produce IFN gamma resulting in nitric oxide-mediated amastigote apoptosis. Vet Immunol Immunopathol. 2005, 106: 247-257.
Article
CAS
PubMed
Google Scholar
Neogy AB, Vouldoukis L, Da Costa JM, Monjour L: Exploitation of parasite-derived antigen in therapeutic success against canine visceral leishmaniosis. Vet Parasitol. 1994, 54: 367-373.
Article
CAS
PubMed
Google Scholar
Vouldoukis I, Drapier JC, Nüssler AK, Tselentis Y, Da Silva OA, Gentilini M, Mossalayi DM, Monjour L, Dugas B: Canine visceral leishmaniasis: successful chemotherapy induces macrophage antileishmanial activity via the L-arginine nitric oxide pathway. Antimicrob Agents Chemother. 1996, 40: 253-256.
PubMed Central
CAS
PubMed
Google Scholar
Vouldoukis I, Rougier S, Dugas B, Pino P, Mazier D, Woehrlé F: Canine visceral leishmaniasis: Comparison of in vitro leishmanicidal activity of marbofloxacin, meglumine antimoniate and sodium stibogluconate. Vet Parasitol. 2006, 135: 137-146.
Article
CAS
PubMed
Google Scholar
Tietze F: Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem. 1969, 27: 502-522.
Article
CAS
PubMed
Google Scholar
Brigelius R, Muckel C, Akerboom TPM, Sies H: Identification and quantitation of glutathione in hepatic protein mixed disulfides and its relationship to glutathione disulfide. Biochem Pharmacol. 1983, 32: 2529-2534.
Article
CAS
PubMed
Google Scholar
Güntherberg H, Rost J: The true oxidized glutathione content of red blood cells obtained by new enzymic and paper chromatographic methods. Anal Biochem. 1966, 15: 205-210.
Article
PubMed
Google Scholar
Gradoni L, Foglia Manzillo V, Pagano A, Piantedosi D, De Luna R, Gramiccia M, Scalone A, Di Muccio T, Oliva G: Failure of a multi-subunit recombinant leishmanial vaccine (MML) to protect dogs from Leishmania infantum infection and to prevent disease progression in infected animals. Vaccine. 2005, 23: 5245-5251.
Article
CAS
PubMed
Google Scholar
Paltrinieri S, Solano-Gallego L, Fondati A, Lubas G, Gradoni L, Castagnaro M, Crotti A, Maroli M, Oliva G, Roura X, Zatelli A, Zini E: Guidelines for diagnosis and clinical classification of leishmaniasis in dogs. J Am Vet Med Assoc. 2010, 236: 1184-1191.
Article
PubMed
Google Scholar
Reis AB, Martins-Filho OA, Teixeira-Carvalho A, Carvalho MG, Mayrink W, França-Silva JC, Giunchetti RC, Genaro O, Corrêa-Oliveira R: Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis. Res Vet Sci. 2006, 81: 68-75.
Article
CAS
PubMed
Google Scholar
Moreno J, Alvar J: Canine leishmaniasis: epidemiological risk and the experimental model. Trends Parasitol. 2002, 18: 399-405.
Article
PubMed
Google Scholar
Fernández-Cotrina J, Iniesta V, Belinchón-Lorenzo S, Muñoz-Madrid R, Serrano F, Parejo JC, Gómez-Gordo L, Soto M, Alonso C, Gómez-Nieto LC: Experimental model for reproduction of canine visceral leishmaniosis by Leishmania infantum. Vet Parasitol. 2013, 192: 118-128.
Article
PubMed
Google Scholar
Poot J, Rogers ME, Bates PA, Vermeulen A: Detailed analysis of an experimental challenge model for Leishmania infantum (JPC strain) in dogs. Vet Parasitol. 2005, 130: 41-53.
Article
CAS
PubMed
Google Scholar
Garg R, Dube A: Animal models for vaccine studies for visceral leishmaniasis. Indian J Med Res. 2006, 123: 439-454.
PubMed
Google Scholar
Lemesre J-L, Holzmuller P, Cavaleyra M, Gonçalves RB, Hottin G, Papierok G: Protection against experimental visceral leishmaniasis infection in dogs immunized with purified excreted secreted antigens of Leishmania infantum promastigotes. Vaccine. 2005, 23: 2825-2840.
Article
CAS
PubMed
Google Scholar
Bourdoiseau G, Hugnet C, Gonçalves RB, Vézilier F, Petit-Didier E, Papierok G, Lemesre JL: Effective humoral and cellular immunoprotective responses in Li ESAp-MDP vaccinated protected dogs. Vet Immunol Immunopathol. 2009, 128: 71-78.
Article
CAS
PubMed
Google Scholar
Mayrink W, Genaro O, Silva JC, da Costa RT, Tafuri WL, Toledo VP, da Silva AR, Reis AB, Williams P, da Costa PW: Phase I and II open clinical trials of a vaccine against Leishmania chagasi infections in dogs. Mem Inst Oswaldo Cruz. 1996, 91: 695-697.
Article
CAS
PubMed
Google Scholar
Genaro O, Pinto JA, Da Costa CA, França-Silva JC, Costa RT, Silva JC, Sanguinetti LSR, Vieira EP, Toledo VPCP, Mayrink W: Phase III randomized double blind clinical trial of the efficacy of a vaccine against canine visceral leishmaniasis in urban area of Montes Claros, MG, Brazil [abstract]. Mem Inst Oswaldo Cruz. 1996, 91: 166-
Google Scholar
Rafati S, Nakhaee A, Taheri T, Taslimi Y, Darabi H, Eravani D, Sanos S, Kaye P, Taghikhani M, Jamshidi S, Rad MA: Protective vaccination against experimental canine visceral leishmaniasis using a combination of DNA and protein immunization with cysteine proteinases type I and II of L. infantum. Vaccine. 2005, 23: 3716-3725.
Article
CAS
PubMed
Google Scholar
Rodríguez-Cortés A, Ojeda A, López-Fuertes L, Timón M, Altet L, Solano-Gallego L, Sánchez-Robert E, Francino O, Alberola J: Vaccination with plasmid DNA encoding KMPII, TRYP, LACK and GP63 does not protect dogs against Leishmania infantum experimental challenge. Vaccine. 2007, 25: 7962-7971.
Article
PubMed
Google Scholar
Moreno J, Nieto J, Masina S, Cañavate C, Cruz I, Chicharro C, Carrillo E, Napp S, Reymond C, Kaye PM, Smith DF, Fasel N, Alvar J: Immunization with H1, HASPB1 and MML Leishmania proteins in a vaccine trial against experimental canine leishmaniasis. Vaccine. 2007, 25: 5290-5300.
Article
PubMed Central
CAS
PubMed
Google Scholar
Maia C, Nunes M, Cristóvão J, Campino L: Experimental canine leishmaniasis: clinical, parasitological and serological follow-up. Acta Trop. 2010, 116: 193-199.
Article
PubMed
Google Scholar
Santarém N, Silvestre R, Tavares J, Silva M, Cabral S, Maciel J, Cordeiro-da-Silva A: Immune response regulation by leishmania secreted and nonsecreted antigens. J Biomed Biotechnol. 2007, 2007: 85154-
Article
PubMed Central
PubMed
Google Scholar
Reis AB, Giunchetti RC, Carrillo E, Martins-Filho OA, Moreno J: Immunity to Leishmania and the rational search for vaccines against canine leishmaniasis. Trends Parasitol. 2010, 26: 341-349.
Article
CAS
PubMed
Google Scholar
Bourdoiseau G, Hugnet C, Papierok G-M, Lemesre JL: La leishmaniose canine à Leishmania infantum: essais d’immunothérapie. Bull Acad Vet Fr. 2004, 157: 63-67.
Google Scholar
Lemesre JL, Holzmuller P, Gonçalves RB, Bourdoiseau G, Hugnet C, Cavaleyra M, Papierok G: Long-lasting protection against canine visceral leishmaniasis using the LiESAp-MDP vaccine in endemic areas of France: double-blind randomised efficacy field trial. Vaccine. 2007, 25: 4223-4234.
Article
CAS
PubMed
Google Scholar
Paradies P, Sasanelli M, de Caprariis D, Testini G, Traversa D, Lia RP, Dantas-Torres F, Otranto D: Clinical and laboratory monitoring of dogs naturally infected by Leishmania infantum. Vet J. 2010, 186: 370-373.
Article
PubMed
Google Scholar
Oliva G, Scalone A, Foglia Manzillo V, Gramiccia M, Pagano A, Di Muccio T, Gradoni L: Incidence and time course of Leishmania infantum infections examined by parasitological, serologic, and nested-PCR techniques in a cohort of naive dogs exposed to three consecutive transmission seasons. J Clin Microbiol. 2006, 44: 1318-1322.
Article
PubMed Central
PubMed
Google Scholar
Boggiatto PM, Ramer-Tait AE, Metz K, Kramer EE, Gibson-Corley K, Mullin K, Hostetter JM, Gallup JM, Jones DE, Petersen CA: Immunologic indicators of clinical progression during canine Leishmania infantum infection. Clin Vaccine Immunol. 2010, 17: 267-273.
Article
PubMed Central
CAS
PubMed
Google Scholar
De Luna R, Vuotto ML, Ielpo MT, Ambrosio R, Piantedosi D, Moscatiello V, Ciaramella P, Scalone A, Gradoni L, Mancino D: Early suppression of lymphoproliferative response in dogs with natural infection by Leishmania infantum. Vet Immunol Immunopathol. 1999, 70: 95-103.
Article
CAS
PubMed
Google Scholar
Alves CF, de Amorim IFG, Moura EP, Ribeiro RR, Alves CF, Michalick MS, Kalapothakis E, Bruna-Romero O, Tafuri WL, Teixeira MM, Melo MN: Expression of IFN-gamma, TNF-alpha, IL-10 and TGF-beta in lymph nodes associates with parasite load and clinical form of disease in dogs naturally infected with Leishmania (Leishmania) chagasi. Vet Immunol Immunopathol. 2009, 128: 349-358.
Article
CAS
PubMed
Google Scholar
Travi BL, Osorio EY, Saldarriaga OA, Cadena H, Tabares CJ, Peniche A, Lee S, Melby PC: Clinical, parasitologic, and immunologic evolution in dogs experimentally infected with sand fly-derived Leishmania chagasi promastigotes. Am J Trop Med Hyg. 2009, 81: 994-1003.
Article
CAS
PubMed
Google Scholar
Vouldoukis I, Bécherel PA, Riveros-Moreno V, Arock M, da Silva O, Debré P, Mazier D, Mossalayi MD: Interleukin-10 and interleukin-4 inhibit intracellular killing of Leishmania infantum and Leishmania major by human macrophages by decreasing nitric oxide generation. Eur J Immunol. 1997, 27: 860-865.
Article
CAS
PubMed
Google Scholar
Travi BL, Tabares CJ, Cadena H, Ferro C, Osorio Y: Canine visceral leishmaniasis in Colombia: relationship between clinical and parasitologic status and infectivity for sand flies. Am J Trop Med Hyg. 2001, 64: 119-124.
CAS
PubMed
Google Scholar
Courtenay O, Quinnell RJ, Garcez LM, Shaw JJ, Dye C: Infectiousness in a cohort of brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission. J Infect Dis. 2002, 186: 1314-1320.
Article
PubMed
Google Scholar
Britti D, Sconza S, Morittu VM, Santori D, Boari A: Superoxide dismutase and Glutathione peroxidase in the blood of dogs with Leishmaniasis. Vet Res Commun. 2008, 32 (Suppl 1): S251-S254.
Article
PubMed
Google Scholar
Heidarpour M, Soltani S, Mohri M, Khoshnegah J: Canine visceral leishmaniasis: relationships between oxidative stress, liver and kidney variables, trace elements, and clinical status. Parasitol Res. 2012, 111: 1491-1496.
Article
CAS
PubMed
Google Scholar
Van Assche T, Deschacht M, da Luz RA, Maes L, Cos P: Leishmania-macrophage interactions: insights into the redox biology. Free Radic Biol Med. 2011, 51: 337-351.
Article
CAS
PubMed
Google Scholar
Nakamura H, Nakamura K, Yodoi J: Redox regulation of cellular activation. Annu Rev Immunol. 1997, 15: 351-369.
Article
CAS
PubMed
Google Scholar
Gmünder H, Dröge W: Differential effects of glutathione depletion on T cell subsets. Cell Immunol. 1991, 138: 229-237.
Article
PubMed
Google Scholar
Buchmüller-Rouiller Y, Corrandin SB, Smith J, Schneider P, Ransijn A, Jongeneel CV, Mauël J: Role of glutathione in macrophage activation: effect of cellular glutathione depletion on nitrite production and leishmanicidal activity. Cell Immunol. 1995, 164: 73-80.
Article
PubMed
Google Scholar
Murata Y, Shimamura T, Hamuro J: The polarization of T(h)1/T(h)2 balance is dependent on the intracellular thiol redox status of macrophages due to the distinctive cytokine production. Int Immunol. 2002, 14: 201-212.
Article
CAS
PubMed
Google Scholar
Peterson JD, Herzenberg LA, Vasquez K, Waltenbaugh C: Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns. Proc Natl Acad Sci U S A. 1998, 95: 3071-3076.
Article
PubMed Central
CAS
PubMed
Google Scholar