Table 2 Amino acid sequence comparison between the French strains and the OIE-recommended vaccine strains
Amino acid position | PB2 | PB1 | |||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
63 | 65 | 105 | 251 | 295 | 377 | 395 | 398 | 411 | 660 | 661 | 667 | 684 | 686 | 699 | 731 | 754 | 94 | 114 | 119 | 200 | 203 | 329 | 377 | 578 | 584 | 618 | 621 | 644 | 715 | 754 | |
A/equine/Ohio/1/2003 | I | E | T | R | V | A | A | I | I | K | A | V | A | V | K | V | I | F | I | V | V | R | Q | D | K | R | E | K | V | V | R |
A/equine/South Africa/4/2003 | – | – | – | – | – | T | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
A/equine/Ohio/113461-1/2005 | – | – | – | – | – | – | – | V | V | R | – | – | – | – | – | I | – | L | – | – | – | – | – | – | I | – | – | R | – | – | – |
A/equine/Richmond/2007 | – | – | A | K | – | – | – | V | – | – | – | – | – | – | – | – | – | L | – | M | – | – | R | E | – | – | D | – | – | – | – |
A/equine/Beuvron-en-Auge/2/2009 | V | – | – | – | I | – | V | V | – | – | – | I | – | I | – | – | – | L | – | – | – | K | – | – | – | Q | – | R | – | – | – |
A/equine/Paris/1/2018 | V | K | – | – | – | – | – | V | – | – | T | I | T | I | R | – | V | L | V | – | I | – | – | – | – | Q | – | R | I | A | G |
| Â | PA | NP | Â | Â | Â | Â | Â | Â | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Amino acid position | 59 | 64 | 86 | 98 | 210 | 237 | 259 | 321 | 335 | 348 | 354 | 367 | 409 | 465 | 476 | 505 | 538 | 626 | 636 | 136 | 214 | 257 | 359 | 430 | 450 | Â | Â | Â | Â | Â | Â |
A/equine/Ohio/1/2003 | E | E | M | T | T | E | P | S | L | L | T | K | S | I | A | V | E | K | V | M | R | I | T | T | N | Â | Â | Â | Â | Â | Â |
A/equine/South Africa/4/2003 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | I | – | – | – | – | K | – | – | – | – |  |  |  |  |  |  |
A/equine/Ohio/113461–1/2005 | – | – | – | – | – | – | – | – | – | – | – | – | – | V | – | – | – | – | – | – | – | – | – | – | – |  |  |  |  |  |  |
A/equine/Richmond/2007 | – | D | I | – | M | K | – | N | – | – | I | – | – | – | T | I | – | R | – | I | – | T | A | – | S |  |  |  |  |  |  |
A/equine/Beuvron-en-Auge/2/2009 | – | – | – | A | – | – | S | – | – | I | I | – | N | V | – | – | K | – | I | – | – | – | – | – | – |  |  |  |  |  |  |
A/equine/Paris/1/2018 | K | – | – | – | – | K | S | – | I | I | I | R | N | – | – | – | – | – | – | – | – | – | – | I | – |  |  |  |  |  |  |
| Â | M1 | M2 | NS1 | NEP | Â | Â | Â | Â | Â | Â | Â | Â | Â | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Amino acid position | 15 | 80 | 95 | 208 | 214 | 248 | 19 | 59 | 85 | 87 | 89 | 22 | 48 | 66 | 84 | 129 | 156 | 207 | 209 | 210 | 212 | 52 | Â | Â | Â | Â | Â | Â | Â | Â | Â |
A/equine/Ohio/1/2003 | V | V | R | R | Q | M | C | L | D | E | G | F | S | E | V | I | V | H | N | G | P | M | Â | Â | Â | Â | Â | Â | Â | Â | Â |
A/equine/South Africa/4/2003 | – | – | – | – | – | – | – | – | – | D | – | V | – | – | – | T | I | – | – | – | – | – |  |  |  |  |  |  |  |  |  |
A/equine/Ohio/113461-1/2005 | – | – | – | – | – | – | – | M | – | D | – | – | – | – | – | – | – | – | – | – | – | – |  |  |  |  |  |  |  |  |  |
A/equine/Richmond/2007 | I | I | K | K | E | – | – | – | S | D | S | – | I | – | I | – | – | Y | – | – | – | – |  |  |  |  |  |  |  |  |  |
A/equine/Beuvron-en-Auge/2/2009 | – | – | – | – | – | – | – | M | G | D | – | – | – | K | – | – | – | – | – | W | – | I |  |  |  |  |  |  |  |  |  |
A/equine/Paris/1/2018 | I | – | – | – | – | I | Y | M | – | D | – | – | – | K | – | – | – | N | I | – | S | L |  |  |  |  |  |  |  |  |  |