Figure 6
From: Pasteurella multocida activates Rassf1-Hippo-Yap pathway to induce pulmonary epithelial apoptosis
Pasteurella multocida activates the Rassf1-Hippo-Yap pathway in rabbit models. A Immunohistochemical staining for Rassf1, p-Lats1, p-Yap, and Yap in healthy and infected rabbit lungs with 109 CFU PmCQ2 for 36 h. Scale bar = 200 µm. For p-Yap, Scale bar = 100 µm. B Pasteurella multocida manipulates the Hippo-Yap pathway in lung epithelial cells through transcriptional regulation of Rassf1, leading to degradation of Yap via the proteasome and inducing excessive apoptosis in pulmonary epithelial cells. In contrast, pharmacological inhibition of the Hippo-Yap pathway by XMU-MP-1 rescued the transcriptional function of Yap, thereby attenuating Pm-induced lung injury and reducing animal mortality.