Figure 6

NCP BVDV-induced mitophagy restricts MAVS-mediated type I interferon signaling. A Western blot analysis of MAVS expression in NCP BVDV-infected (MOI = 5) cells at the indicated time points post-infection. B Western blot analysis of MAVS expression in CCCP-treated cells at 0 hpi, 4 hpi, 8 hpi and 12 hpi. C MDBK cells were transfected with siParkin or siNC for 24 h. Then, the cells were infected with NCP BVDV (MOI = 5), Western blot assays were performed to determine the MAVS, Parkin and NS4B expression at 48 hpi. Data are given as means ± standard deviation (SD) from three independent experiments. P values were calculated using the Student t test. An asterisk indicates a comparison with the indicated control. *P < 0.05; **P < 0.01; ns: not significant.