Figure 2

Effects of inflammation and oxidative stress of LPS on immortalized bMECs. A, B NF-κB signaling pathway activation of bMECs induced by LPS. C, D Keap1/Nrf2 signaling pathway activation of bMECs induced by LPS. E, F NLRP3 inflammation pathway activation of bMECs induced by LPS and ATP (10 mmol/L) for 1 h and/or MCC950 (10 μmol/L) for 12 h. G, H Protein expression of TLR4 of bMECs induced by LPS. I, J Intracellular ROS production of bMECs induced by LPS. **p < 0.01, differences compared to control group. #p < 0.05 and ##p < 0.01 differences compared to LPS or LPS + ATP-induced samples.