Evaluating the potential of whole-genome sequencing for tracing transmission routes in experimental infections and natural outbreaks of bovine respiratory syncytial virus

Table 1 Experiments and studies from which samples originated

Study	Year (reference)	Infection method	Challenge virus^a
A	2002 [29]	Experimental aerosol	BRSVDKp7: Cell lysate containing DK 9402022 obtained by isolation and seven passages in FBL [35]
B	2010 [30]	Experimental aerosol	BRSVDKp7: Cell lysate containing DK 9402022 obtained by isolation and two passages in FBL and five passages in FBT [35]
C	2012 [31]	Experimental aerosol	BRSVSnook: BAL containing the BRSV Snook strain obtained by isolation in CK followed by three passages in gnotobiotic calves [36]
D	2010 [32]	Experimental intranasal/intratracheal	BRSV3761p2: Cell lysate containing BRSV-3761, obtained by isolation in FBT followed by three passages in newborn calves [32]
F	2018 [33]	Experimental aerosol	Same as experiment C
G	2018 (This work)	Experimental aerosol	BRSV/Sweden/HPIG-SLU-620-Lovsta/2016 p4: Cell lysate containing BRSV-SE2016-620 obtained by isolation and four passages in FBT, or BAL containing the same strain that had been passaged once or twice in calves
O	2020 (This work)	Natural outbreak	N/A

FBL foetal bovine lung cells, FBT foetal bovine turbinate cells, BAL bronchoalveolar lavage, CK calf kidney cells.

ISSN: 1297-9716