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Table 2 Examples of MGEs carrying AMR genes found in S. suis genomes

From: How Streptococcus suis escapes antibiotic treatments

MGE

Hosts

AMR genes

Integration site (s)

Integrase family

References

ICEs

     

 Tn916

     

  Tn916

S. suis, S. agalactiae, S. pneumoniae, S. mutants, E. faecalis, C. difficile

tet(M)

llmO

Tyrosine

[145]

  dICE_Tn916

S. suis

tet(O)

  

[145]

  dICE_Tn916

S. suis

tet(M)

  

[145]

 Tn5252

     

  ICE_Tn5252_rplL*1

S. suis, S. agalactiae, S. pneumoniae, S. pyogenes

tet(O), tet(O/W/32/O), tet(40), erm(B), aph(3’)-IIIa, ant(9’), ant(6’)-Ia, sat4

rplL

Tyrosine

[89, 145]

  ICE_Tn5252_rumA*1

S. suis, S. agalactiae, S. pneumoniae, S. pyogenes

tet(M), tet(L), tet(O), tet(O/W/32/O), erm(B), aph(3’)-III, ant(6’)-Ia, sat4

rumA

Tyrosine

[89, 97, 143, 145]

  ICE_Tn5252_mutT*1

S. suis

tet(L), tet(O), tet(O/W/32/O), erm(B), msr(C), mef(A)

mutT

Tyrosine

[89, 145]

  ICE_Tn5252_rbgA*1

S. suis

erm(B)

rbgA

Tyrosine

[145]

  ICE_Tn5252_ llmO *1

S. suis

tet(M)

llmO

Tyrosine

[145]

  dICE_Tn5252

S. suis

tet(O), tet(40)

rplL

Tyrosine

[145]

  Partial_Tn5252

S. suis

tet(O/W/32/O), erm(B), aph(3’)-IIIa, ant(9’), sat4

rplL

Tyrosine

[145]

  ICESsD9*2*3

S. suis, E. faecalis

tet(O), erm(B)

rplL

Tyrosine

[143, 149]

  ICESsu32457*2*4

S. suis, S. agalactiae, S. pneumoniae, S. pyogenes

tet(40), tet(O/W/32/O), erm(B), ant(6’)-Ia, aph(3’)

rplL

Tyrosine

[143, 150, 244]

  ICESsuSC216*2

S. suis

tet(O), erm(B), optrA, aadD

rplL

Tyrosine

[97]

  Tandem_ICESsuSC317*2

S. suis

tet(L), tet(O), optrA

rumA

SR

[97]

  ICESsuBSB6*2

     
 

S. suis

tet(O/W/32/O), erm(B), aph(3’)-IIIa, ant(6’)-Ia, sat4, vanG operon

rplL

Tyrosine

[121]

  ICESsuJH1308-2*2

S. suis

tet(M), ant(6’)-Ia

rplL

Tyrosine

[89]

  ICESsuJH1301*2

S. suis

tet(O), erm(B), aph(3’)-III

rplL

Tyrosine

[89]

 Tn1549

     

  dICE_Tn1549_rplL

S. suis

tet(O/W/32/O)

rplL

Tyrosine

[145]

  ICE_Tn1549_rbgA

S. suis

erm(B)

rbgA

Tyrosine

[145]

  Tn1549

S. suis

vanB operon

hsdM

Tyrosine

[89]

  ICESp1108

S. suis, S. agalactiae, S. pneumoniae,S. pyogenes

tet(L), tet(W), erm(B), lnu(B), erm(TR), ant(6’)-Ia, cat

rumA

Tyrosine

[89]

 vanG

     

  ICE_vanG_lysS

S. suis

tet(W)

lysS

 

[145]

 TnGBS2

     

  ICE_TnGBS2

S. suis, S. agalactiae

tet(L), aph(3’)-IIIa, ant(6)

Diverse insertion sites, but not rplL

Tyrosine

[145, 245]

  ICESsuTYPE3_rplL

S. suis, S. agalactiae, S. pneumoniae, S. pyogenes

tet(L), tet(W), erm(B), lnu(B), ant(6’)-Ia, cat

rplL

Tyrosine

[89]

IMEs

     

 Integrated in MGEs

     

  IME_PPI*3

S. suis, S. thermophilus

tet(O), tet(40), erm(B)

PPI

SR

[145]

  IME_SNF2*3

S. suis

tet(O), erm(B)

SNF2

SR

[145]

Integrated in chromosome

     

  IME_SsuNSUI181_tRNALeu

S. suis

aph(3’)-IIIa, ant(6)-Ia, sat4, vanZ

tRNA-leu

Tyrosine

[145]

  IME_SsuNSUI231_rpsI

S. suis

tet(O)

rpsI

Tyrosine

[145]

  IME_HTH-XRE-reg

S. suis

ant(6)-Ia

HTH-XRE regulator

SR

[145]

 Prophages

     

  Prophage_rumA

S. suis

tet(O/W/32/O), tet(W), erm(B), lnu(B), lnu(C), lsa(E), mef(A), ant(6’)-Ib, aph(3’)-IIIa, ant(9’), sat4

rumA

 

[145]

  ΦSC181

S. suis

mef(A), aacA, aphD, cat, optrA

rumA

 

[97]

  Φm46.1*4

S. suis, S. pyogenes

tet(O), mef(A)

rumA

Site-specific recombinase

[89, 97]

  ΦSsu1135/10

S. suis

erm(B), ant(6’)-Ia, aph(3)-IIIa

rumA

 

[170]

  ΦSsUD.1

S. suis, S. pyogenes

tet(W), erm(B), ant(6’)-Ia, aph(3’)-III, sat4

rumA

 

[89, 97, 170]

  ΦJH1301

S. suis

mef(A), ant(6’)-Ia, cat, sat4

cysM / rumA / SSU1958

 

[89]

  1. ICEs, IMEs, and prophages are listed including the identified AMR genes, integration site, and integrase family (if known). ICEs are organized in families according to their conjugation module, and IMEs are grouped into two categories (indicated in bold). The presence of these elements in other bacterial species is notified. The table is not intended to be exhaustive but illustrative; for further information, see Bellanger et al. [144]
  2. MGEs, mobile genetic elements; AMR, antimicrobial resistance; ICEs, integrative and conjugative elements; llmO, luciferase-like monooxygenase gene; SNF2, SNF2-family helicase; rplL, 50S ribosomal protein L7/L12; rum, RNA uracil methyltransferase; mutT, MutT/NUDIX hydrolase-family protein; rbgA, ribosome biogenesis GTPase A; dICE, derivative ICE; SR, serine recombinase; hsdM, type I restriction system adenine methylase; rplU, 50S ribosomal protein L21; IMEs, integrative and mobile elements; PPI, peptidyl-prolyl isomerase; rpsI, 30S ribosomal protein S9; HTH_XRE, helix-turn-helix XRE-family-like proteins; cysM, cysteine synthase.*1ICEs belonging to sub-family Tn5252. *2ICEs belonging to sub-family ICESa2603. *3MGEs studied for transfer between bacteria. erm(TR) genes include erm(B), erm(T) and an erm(A) subclass*4Prophage Φm46.1 is located in S. suis in tandem with several ICEs but can also behave as an independent element [89].
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Veterinary Research

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