Figure 4
Postimmunization evaluation of mice. Mice were administered JOL401, JOL2782, JOL2837, or a PBS control via intramuscular inoculation and the peroral route. A. Body weight changes were noted up to 21 days post-inoculation. B. Survival rate curve for mice. The survival of mice was observed for up to 21 days. A bacterial concentration of 1 × 107 CFU/mouse in PBS was inoculated into left thigh muscles for the IM route, and 1 × 108 CFU/mouse was administered through the mouth for the PO route. All JOL401 IM-inoculated mice died within 4 dpi. The level of significance was p < 0.05 as measured by multiple unpaired t tests. The signs * and # denote a significant difference in comparison with the control group at the respective time point for the JOL401 and JOL2782 strains, respectively.