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Fig. 2 | Veterinary Research

Fig. 2

From: A porcine reproductive and respiratory syndrome virus (PRRSV)-specific IgM as a novel adjuvant for an inactivated PRRSV vaccine improves protection efficiency and enhances cell-mediated immunity against heterologous PRRSV challenge

Fig. 2

IgM-adjuvanted inactivated PRRSV vaccine demonstrated improved protection of piglets against heterologous HP-PRRSV challenge. A. All vaccinated animals or nonvaccinated controls were inoculated with 1.0 × 105 TCID50 of HP-PRRSV-XJA1 via both intramuscular and intranasal routes. Clinical signs and survival rates were monitored daily for a total of 21 days. B. Representative ventral and dorsal lung images from surviving piglets of each group were captured immediately after piglets were necropsied at 21 dpi. Tissue samples from the lungs of all the animals necropsied at 21 dpi were fixed in 10% neutral buffered formalin, embedded in paraffin blocks and sectioned for histological analysis. The sections were stained with haematoxylin and eosin (H&E) to facilitate the observation of micropathological changes.

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Veterinary Research

ISSN: 1297-9716