Alternating 3 different influenza vaccines for swine in Europe for a broader antibody response and protection

Table 2 Experimental design of the study.

Prime-boost regimen	Group	Vaccinations			Challenge (week 14)
Prime-boost regimen	Group	First (week 0)	Second (week 4)	Third (week 10)	Challenge (week 14)
n.a	Mock-vaccinated challenge control	PBS	PBS	PBS	A/swine/Gent/8/2018
Homologous	3×TIV	TIV	TIV	TIV
	3×BIV	BIV	BIV	BIV
	3×MOV	MOV	MOV	MOV
Heterologous	TIV–BIV–MOV	TIV	BIV	MOV
Heterologous	BIV–TIV–MOV	BIV	TIV	MOV

n.a.: not applicable; PBS: phosphate buffered saline; TIV: Respiporc® FLU3; BIV: GRIPORK®; MOV: Respiporc® FLUpan H1N1.

ISSN: 1297-9716