Alternating 3 different influenza vaccines for swine in Europe for a broader antibody response and protection

Table 1 Swine influenza virus vaccines included in the study and their composition.

Vaccine	Influenza virus strains	Subtype	HA clade	NA lineage	Adjuvant	Vaccine dose (mL)	Antigenic content per dose
Respiporc^® FLU3 (TIV)	A/swine/Haselünne/IDT2617/2003	H1N1	1C.2.2	N1_av	Carbomer	2	≥ 10.22 log₂ GMNU
	A/swine/Bakum/1832/2000	H1N2	1B.1.2.1	N2_swSC94			≥ 12.34 log₂ GMNU
	A/swine/Bakum/IDT1769/2003	H3N2	3.1970.1	N2_swG84			≥ 10.53 log₂ GMNU
GRIPORK^® (BIV)	A/swine/Olost/84	H1N1	1C.1.2-like	N1_av	Oil	2	7.48 log₁₀ EID₅₀
GRIPORK^® (BIV)	A/Port Chalmers/1/73	H3N2	3.1970.1	N2_swG84	Oil	2	7.40 log₁₀ EID₅₀
Respiporc^® FLUpan H1N1 (MOV)	A/Jena/VI5258/2009	pH1N1*	1A.3.3.2	N1_pdm	Carbomer	1	≥ 16 HAU

GMNU, geometric mean of neutralizing units induced in guinea pigs after 2 immunizations with 0.5 mL of the vaccine; EID₅₀, 50% egg infectious dose before inactivation; HAU, hemagglutinating units.
^*pH1N1, 2009 pandemic H1N1 virus.

ISSN: 1297-9716