Table 1 Vaccine candidates.
From: A Brucella melitensis H38ΔwbkF rough mutant protects against Brucella ovis in rams
Vaccine | Genetic characteristics | Relevant phenotype | References |
|---|---|---|---|
Rev1::wbdRΔwbkC | Rev 1 wbkC (formyl-transferase gene) deleted mutant carrying a mini-Tn7 insert with E. coli O157:H7 wbdR (acetyl-transferase) | S-LPS with N-acetyl-perosamine O-PS | [19] |
H38ΔwbkF | B. melitensis H38 wbkF (bactoprenol priming for O-PS polymerization gene) deleted mutant | R-LPS with intact core oligosaccharide | This work |
Bov::CAΔwadB | B. ovis PA wadB (core sugar glycosyl transferase gene) deleted mutant carrying a mini-Tn7 insert with the carbonic anhydrases (CAI and CAII) genes of B. abortus 2308 W | CO2-independent; R-LPS with a truncated core oligosaccharide | This work. ΔwadB and::CA single mutants in [27] and [30], respectively |