Table 2 Experimental design for studies B and C – monovalent and bivalent vaccine evaluation

Study B

T01

Saline Control

24

Study Day 0 ^a

2 mL intramuscular in right neck

Study Day 21

2 mL intramuscular in Left neck

2 mL intranasal (1 mL each nare)

PCV2a

Study Day 42

T02

cPCV2a

24

T03

cPCV2a + cPCV2b

24

Study C

T01

Saline control

24

Study Day 22

2 mL intramuscular in Left neck

2 mL intranasal (1 mL each nare)

PCV2b

Study Day 43

T02

cPCV2b

24

T03

cPCV2a + cPCV2b

24