Figure 5

Histopathological findings and viral antigen detection in H5 HPAIV naturally infected ducks. A Lung, non-specific diffuse congestion. Absence of NP positive cells. B Trachea, lymphoplasmacytic infiltration of lamina propria. Absence of NP positive cells. C Spleen, macrophagic infiltration, lymphoid and reticular cell hyperplasia. Rare NP-positive leukocytes. D Intestine, lympho-plasmacytic infiltration of lamina propria. Sparse NP-cells within lamina propria, presumably leukocytes. E Brain, non suppurative encephalitis (observed in one subject). Absence of NP positive cells. F Heart, myocardial lympho-plasmacytic infiltration. Rare NP-positive cells within interstitium. G Liver, within normal limits with non-specific portal infiltration. Absence of NP positive cells. H Bronchus, necrotizing bronchitis with lymphoplasmacytic infiltration and congestion (observed in one subject). Frequent NP-Positive epithelial cells within mucosa and luminal debris. Hematoxylin and eosin (HE). Anti-nucleoprotein immunohistochemistry (IHC).