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Figure 2 | Veterinary Research

Figure 2

From: Dihydromyricetin alleviates Escherichia coli lipopolysaccharide-induced hepatic injury in chickens by inhibiting the NLRP3 inflammasome

Figure 2

MCC950 repressed the activation of the NLRP3 inflammasome. A Western blot analyses of the expression of NLRP3, caspase1-p20, and β-actin (loading control) in total tissue lysates. B, C Changes in the protein expression levels of NLRP3 (fold change in NLRP3/β-actin) and caspase1-p20 (fold change in caspase1-p20/β-actin) in livers from chickens administered MCC950 (5 mg/kg) followed by LPS (60 mg/kg). D, E Changes in the mRNA expression levels of NLRP3 (fold change in NLRP3/β-actin) and pro-caspase-1 (fold change in pro-caspase-1/β-actin) in livers from chickens stimulated by LPS (60 mg/kg) with or without MCC950 administration (5 mg/kg). Values are expressed as the mean ± SD for each group (n = 6). **P < 0.01 vs. the control group. ##P < 0.01 vs. the LPS-treated group.

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Veterinary Research

ISSN: 1297-9716