Skip to main content

Table 4 Differentially expressed genes in testicle tissues of experimentally and naturally infected males

From: Identification of molecular biomarkers associated with disease progression in the testis of bulls infected with Besnoitia besnoiti

Analyzed tissue Gene regulation Intravenously inoculated group Subcutaneously inoculated group Intradermally inoculated group
Experimentally infected calves
 Scrotal skin Upregulation CCL24 No significant changes No significant changes
Downregulation IL10; TLR2 IL6; IL8; IL10; SERP; SELE; PLAT; ICAM1; ADAMTS1; IL4; IL17; TGF; TNF IL6; IL8; IL10; IL1a; TLR2; SELE; PLAT; ICAM1; VCAM1; CCL2; CXCL2; TIMP1; ADAMTS1; IL17; TGF; TNF
 Pampiniform plexus Upregulation CCL24 No significant changes CCL24
Downregulation IL6; ADAMTS1 IL6; IL8; IL10; IL1a; SERP; PLAT; CCL2; ADAMTS1; TIMP1; IL17 IL6; IL8; IL10; IL1a; TLR2; SERP; SELE; PLAT; ICAM1; VCAM1; CCL2; TIMP1; ADAMTS1; IL17; TGF; TNF
 Testicular parenchyma Upregulation No significant changes CXCL2 CCL24
Downregulation IL6; IL8; IL10; SERP; CCL2; ADAMTS1; TIMP1 IL6; IL8; SERP; PLAT; CCL2; ADAMTS1; IL17; TGF IL6; IL8; IL10; SELE; PLAT; VCAM1; TIMP1; IL17; TLR2; TNF; TGF
Analyzed tissue Gene regulation Acutely infected bulls without tissue cysts Acutely infected bulls with tissue cysts Chronically infected bulls
Naturally infected animals
 Scrotal skin Upregulation No significant changes No significant changes ICAM1
Downregulation No significant changes No significant changes PLAT; IL8
 Pampiniform plexus Upregulation PLAT; IL1a PLAT; TLR2 ICAM1
Downregulation No significant changes No significant changes PLAT; MMP13
 Testicular parenchyma Upregulation PLAT; IL1a; MMP13; TIMP1; IL6 IL1a; TIMP1 ICAM1
Downregulation IL8; IL4; CCL24 MMP13; IL8; CCL24 PLAT; IL8; MMP13; IL1a; IL6; IL4; TGFB1; CCL24