Cellular and humoral immune responses associated with protection in sheep vaccinated against Teladorsagia circumcincta

Table 3 Levels of serum immunoglobulins against a subset of recombinant vaccine proteins in Canaria Sheep (CS) and Canaria Hair Breed (CHB) sheep vaccinated with a prototype recombinant sub-unit Teladorsagia circumcincta vaccine and subsequently challenged with T. circumcincta

Isotype	Antigen	Group	Mean ± SEM	Cumulative FEC	Worm burden	Worm length	EIU
Correlation
IgA	Tci-MEP-1	CS Vac	1.656 ± 0.058**	−0.364	−0.650*	−0.497	−0.706*
		CS Con	1.188 ± 0.045**	0.473	0.727*	0.309	0.109
		CHB Vac	1.652 ± 0.071**	−0.073	−0.582	−0.321	−0.358
		CHB Con	1.246 ± 0.085**	0.109	0.399	0.385	−0.021
IgG1	Tci- ASP-1	CS Vac	1.877 ± 0.043**	−0.399	−0.196	−0.392	−0.636*
		CS Con	0.991 ± 0.004**	−0.405	0.223	−0.087	0.219
		CHB Vac	1.683 ± 0.067*	0.155	−0.036	−0.285	−0.358
		CHB Con	1.017 ± 0.013*	0.494	0.126	0.308	0.406
	Tci- SAA-1	CS Vac	2.104 ± 0.086**	−0.552	−0.252	−0.699*	−0.608*
		CS Con	0.995 ± 0.002**	0.018	−0.027	−0.391	−0.600
		CHB Vac	1.478 ± 0.089*	−0.191	−0.118	−0.152	−0.612
		CHB Con	0.999 ± 0.001*	0.182	0.280	−0.119	−0.098
IgG2	Tci- ASP-1	CS Vac	2.004 ± 0.049**	−0.399	−0.329	−0.392	−0.587*
		CS Con	0.998 ± 0.003**	−0.100	−0.073	−0.182	0.509
		CHB Vac	1.701 ± 0.059*	0.164	−0.118	−0.067	−0.164
		CHB Con	1.004 ± 0.001*	0.067	0.112	0.028	−0.021

Antibody levels are expressed as (ODI + 1). Only the antigens for which correlations with parasitology variables were established are shown in the table. Associations are expressed as Spearman’s correlation coefficient. Statistically-significant differences within breeds for a specific isotype and antigen and significant correlations are represented with “*” at p < 0.05 and “**” at p < 0.01.

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