Table 3 Consequences of chemical modifications of aptamers
From: Potential applications of aptamers in veterinary science
Location of the chemical modification | Examples | Consequences |
|---|---|---|
Backbone | α-Phosphorothioate | Nuclease-resistance |
Sugar | XNA 2′-Fluoro-RNA 2′-Methoxy-RNA | Nuclease-resistance |
Nucleobase | C5 Unnatural base | Increased chemical diversity Higher affinity |
End of sequence | PEGylation | Reduced renal filtration |