Classical scrapie in small ruminants is caused by at least four different prion strains

Table 1 Goat and sheep TSE isolates employed in this study.

Country of origin	Species origin	Code (reference)	PrP genotype^a	PrP^Sc type
Italy	Goat	I2 [44, 45]	wt	Classical scrapie
		I3 [44, 45]	240PP
		I9 [44, 45]	143HR, 240PS
	Sheep	198/9 [57]	wt
Netherlands	Goat	N1 [44, 45]	143HR, 240PS	Classical scrapie
Netherlands	Goat	N3 [44, 45]	240PP	Classical scrapie
France	Goat	F2 [44, 45]^b	240PS	Classical scrapie
		F3 [44, 45]	240PP
		F6 [44, 45]	240PS
		F16 [44, 45]	240PS
		gtBSE [44]^c	211RQ, 240PS	BSE-C
	Sheep	Langlade [57]	wt	Classical scrapie
		PS21 [22]	wt
		PS09 [22]	wt
		PS83 [58]	171RR
Spain	Goat	S2 [44, 45]	240PS	Classical scrapie
Spain	Goat	S3 [44, 45]	240PP	Classical scrapie
Greece	Goat	G2 [44, 45]	240PP	Classical scrapie
Greece	Goat	G3 [44, 45]	143HR, 240PP	Classical scrapie
Cyprus	Goat	C1 [44, 45]	240PP	Classical scrapie
Cyprus	Goat	C2 [44, 45]	240PP	Classical scrapie
United Kingdom	Goat	UKA2 [44, 45]	240PS	Classical scrapie
	Goat	UKB2 [44, 45]	127GS, 240PP	CH1641-like
	Sheep	CH1641 [59]	wt	CH1641-like
Portugal	Sheep	08-8309	141LL	Classical scrapie
Portugal	Sheep	08-27433	wt;141LL	Classical scrapie

^aPrP genotype: “wt” means A₁₃₆R₁₅₄Q_171. Differences within this haplotype and other prnp polymorphisms are indicated
^bInformation for this experimental case. IC inoculation of sheep scrapie PS 48 (ARQ/ARQ sheep)
^cInformation for this experimental case. IC inoculation of classical cattle-BSE 5 (case#139)

ISSN: 1297-9716