Figure 1
From: Liver organoids in domestic animals: an expected promise for metabolic studies
A schematic description of the generation of liver organoïds from hiPSC. A hiPSC were induced into definitive endoderm before being turned into hepatoblast and more mature hepatocyte following an adaptation of the Rashidi et al., protocol [22]. B The expression of different markers was detected by qRT-PCR and illustrates the loss of pluripotent marker (OCT4), the appearance of endoderm ones (SOX17, FOXA2) and then more specific hepatic markers (HNF4, AFP, ALB). C On mature organoïds, Albumin (ALB) is detectable by immunocytochemistry.