Figure  5
![Figure  5](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs13567-020-00887-6/MediaObjects/13567_2020_887_Fig5_HTML.png)
RPSA mediates Eno-induced apoptosis and BBB damage. A Knockdown of HSPD1 and RPSA in PBMECs after transfection with siRNA RPSA and/or HSPD1; B Knockdown of RPSA inhibited BBB damage induced by Eno based on TEER; C Knockdown of RPSA inhibited BBB damage induced by SS2 based on TEER; D Knockdown of RPSA inhibited PBMEC apoptosis induced by Eno based on flow cytometry of Annexin V/PI-stained PBMECs; E Knockout of RPSA inhibited 293T cell apoptosis induced by Eno; F Knockout of RPSA inhibited 293T cell apoptosis induced by Eno based on Western blotting analysis for activated caspase-3. (*p < 0.05, **p < 0.01, NSp > 0.05).