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Figure  5 | Veterinary Research

Figure  5

From: Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity

Figure  5

RPSA mediates Eno-induced apoptosis and BBB damage. A Knockdown of HSPD1 and RPSA in PBMECs after transfection with siRNA RPSA and/or HSPD1; B Knockdown of RPSA inhibited BBB damage induced by Eno based on TEER; C Knockdown of RPSA inhibited BBB damage induced by SS2 based on TEER; D Knockdown of RPSA inhibited PBMEC apoptosis induced by Eno based on flow cytometry of Annexin V/PI-stained PBMECs; E Knockout of RPSA inhibited 293T cell apoptosis induced by Eno; F Knockout of RPSA inhibited 293T cell apoptosis induced by Eno based on Western blotting analysis for activated caspase-3. (*p < 0.05, **p < 0.01, NSp > 0.05).

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Veterinary Research

ISSN: 1297-9716