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Table 4 Mean pharmacokinetic values (± SD) of cefquinome after IM administration of 1 mg/kg in horses (n = 6) determined by high-performance liquid chromatography

From: Pharmacokinetic and pharmacodynamic integration for optimal dosage of cefquinome against Streptococcus equi subsp. equi in foals

Parameter

Unit

Mean

K01

1/h

1.73 ± .64

K01_HL

h

0.45 ± .16

K10

1/h

0.16 ± .03

K10_HL

h

4.39 ± .79

Cmax

μg/mL

0.73 ± .08

Tmax

h

1.52 ± .42

AUC

μg·h/mL

5.93 ± .55

F

%

37.45 ± 6.16

  1. K01 first-order absorption rate constant, K01_HL the half-life of absorption, K10 first-order elimination rate constant, K10_HL the half-life of elimination, Cmax maximal serum concentration, Tmax time taken to achieve maximal drug concentration, AUC area under the curve, F absolute bioavailability
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Veterinary Research

ISSN: 1297-9716