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Table 4 Mean pharmacokinetic values (± SD) of cefquinome after IM administration of 1 mg/kg in horses (n = 6) determined by high-performance liquid chromatography

From: Pharmacokinetic and pharmacodynamic integration for optimal dosage of cefquinome against Streptococcus equi subsp. equi in foals

Parameter Unit Mean
K01 1/h 1.73 ± .64
K01_HL h 0.45 ± .16
K10 1/h 0.16 ± .03
K10_HL h 4.39 ± .79
Cmax μg/mL 0.73 ± .08
Tmax h 1.52 ± .42
AUC μg·h/mL 5.93 ± .55
F % 37.45 ± 6.16
  1. K01 first-order absorption rate constant, K01_HL the half-life of absorption, K10 first-order elimination rate constant, K10_HL the half-life of elimination, Cmax maximal serum concentration, Tmax time taken to achieve maximal drug concentration, AUC area under the curve, F absolute bioavailability
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Veterinary Research

ISSN: 1297-9716