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Table 2 Protection against virulentB. suisinduced by LPS and metabolic mutants inoculated subcutaneously.

From: Development of attenuated live vaccine candidates against swine brucellosis in a non-zoonotic B. suis biovar 2 background

Vaccine

Dose (CFU/mouse)

Mean ± SD of log10 CFU in spleen of

Bs2WT

Vaccine

Bs2ΔwadB

105

3.97 ± 0.37a,b

2.61 ± 0.97

Bs2Δppdk

105

3.65 ± 0.43a,b

2.39 ± 0.54

Bs2ΔppdkΔwadB

105

4.12 ± 1.09a,b

2.68 ± 1.17

Bs2ΔwbkF

108

3.33 ± 0.36a,b

2.45 ± 0.56

Bs2Δwzm

108

2.83 ± 1.88a,b

2.52 ± 1.50

Rev1

105

3.68 ± 0.78a

2.43 ± 0.56

BSS

–

6.69 ± 0.13

 
  1. Statistical comparison (n = 5) of mean log10 Bs2WT CFU/spleen: ap < 0.001 vs. BSS (unvaccinated) and bp > 0.05 vs. Rev1.
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Veterinary Research

ISSN: 1297-9716