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Table 3 Severity of histological lesions in the lungs, liver, kidneys, spleen and central nervous tissue (CNS) during the respective weeks post-infection (pi) in rabbits (from 5 animals in respective weeks) experimentally orally infected withEncephalitozoon cuniculi.

From: Characterization of humoral and cell-mediated immunity in rabbits orally infected with Encephalitozoon cuniculi

Week pi Lungs Liver Kidneys Spleen CNS
2 +++ + + ++ +
4 ++ ++ ++ ++ ++
6 + ++ +++ ++ +
8 + ++ ++ + +
  1. Extensive histopathological changes throughout the tissue were defined as severe (+++); focal changes as moderate (++); and occasional areas of increased cellularity, or perivascular or periportal cuffing were determined as mild (+).