Figure 1

Workflow production process novel butyrate formulations [Right] Production process of wax by using hot melt extrusion, resulting in a wax matrix carrying the active pharmaceutical ingredient sodium butyrate. To obtain wax+ with the addition of starch, soluble potato starch in dry powder form was added during the mixing step. [Left] Production process of micropellets using wet-extrusion, spheronization and applying a pH-dependent coating. Final product is sodium butyrate with cellulose protected by an additional layer (purple sphere).