Figure 1

In vitro efficacy of the drugs againstE. granulosus s. s.protoscoleces. A Survival of protoscoleces after treatment with LND, 6-AN, and their combination. B Morphologies of protoscoleces after 3 days of treatment with LND, 6-AN, and their combination. a Untreated protoscoleces. White arrow points towards calcareus corpuscles (cc); b Protoscoleces in culture medium containing 0.2% DMSO; c, d, and e Protoscoleces incubated with 40 μM NTZ, 40 μM 6-AN and 40 μM LND, respectively; f Protoscoleces incubated with 20 μM LND + 20 μM 6-AN. Note the distortion and vesiculation of protoscoleces (black arrow), the collapse of suckers (white arrowhead) and the decrease of calcareus corpuscles; g Protoscoleces incubated with 40 μM LND + 40 μM 6-AN.