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Table 1 Overview of the design of the three experiments

From: An atypical weakly haemolytic strain of Brachyspira hyodysenteriae is avirulent and can be used to protect pigs from developing swine dysentery

Experiment number

No of groups (number of pigs per group)

Purpose

Experiment duration following exposure to MU1 (days)

Virulent challenge strains

1

2 (10)

Assess comparative virulence of MU1

49

NSW54

2

3 (12)

Assess virulence of MU1

AND

Assess protection conferred by MU1

73

WA1, BW1, Vic2, NSW5, Q10 (“cocktail”)

3

2 (12)

Assess protection conferred by MU1 and duration

132 (for vaccinates), 117 for positive controls

WA1, BW1, Vic2, NSW5, Q10 (“cocktail”)