Antibiotic | Individual MICa ATB/RTLex | MIC in combinationb ATB/RTLex | MIC fold improvementc ATB/RTLex | ∑FICd |
---|
Pirlimycin | 0.5/16 | 0.004/8 | 128/2 | 0.508 |
Oxytetracycline | 0.5/16 | 0.008/8 | 64/2 | 0.516 |
- aMIC of the antibiotic (ATB) and MIC of the RTL extract (RTLex) when used alone.
- bMIC of the ATB and MIC of the RTLex when used in combination.
- cThe fold improvement of the MIC is the ratio of the MIC alone/MIC in combination for the ATB or the RTLex.
- dA ∑FIC of ≤ 0.5 is defined as synergism; 0.5–1 as additive; > 1–4 as indifference; > 4 as antagonism.