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Table 3 Minimal inhibitory concentrations (MICs, µg/mL) and the fractional inhibitory concentration index (∑FIC) of the Rhodomyrtus tomentosa leaves extract (RTLex) in combination with antibiotics (ATB) against S. aureus strain Newbould

From: Evaluation of a Rhodomyrtus tomentosa ethanolic extract for its therapeutic potential on Staphylococcus aureus infections using in vitro and in vivo models of mastitis

Antibiotic Individual MICa
MIC in combinationb
MIC fold improvementc
Pirlimycin 0.5/16 0.004/8 128/2 0.508
Oxytetracycline 0.5/16 0.008/8 64/2 0.516
  1. aMIC of the antibiotic (ATB) and MIC of the RTL extract (RTLex) when used alone.
  2. bMIC of the ATB and MIC of the RTLex when used in combination.
  3. cThe fold improvement of the MIC is the ratio of the MIC alone/MIC in combination for the ATB or the RTLex.
  4. dA ∑FIC of ≤ 0.5 is defined as synergism; 0.5–1 as additive; > 1–4 as indifference; > 4 as antagonism.