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Table 1 Summary of the 39 B. hyodysenteriae isolates sequenced in this project

From: Weakly haemolytic variants of Brachyspira hyodysenteriae newly emerged in Europe belong to a distinct subclade with unique genetic properties

Isolate Year Country Farm Haemolysis strength Clinical background Sequence type Plasmid type Clone number References
JR88 2016 Germany Farm V Weak Unknown 246 1 1 This study
BH23 2010 UK Farm BF (UK) Weak Surveillance 167 1 2 [32]
D28 2011 Belgium Farm B1 (Belgium) Weak Diarrhoea 172 1 3 [18]
JR11 2014 Germany Farm C Weak Surveillance 134 1 4 [17]
JR12 2014 Germany Farm C Weak Surveillance 134 1 4 [17]
JR13 2014 Germany Farm C Weak Surveillance 134 1 4 [17]
JR15 2014 Germany Farm M Weak Diarrhoea 135 1 5 This study
JR47 2015 Germany Farm R1 Weak Surveillance 191 1 6 This study
JR48 2015 Germany Farm R1 Weak Surveillance 191 1 6 This study
JR51 2015 Germany Farm R1 Weak Surveillance 191 1 6 This study
JR53 2015 Germany Farm R1 Weak Surveillance 191 1 6 This study
JR54 2015 Germany Farm R1 Weak Surveillance 191 1 6 This study
JR56 2015 Germany Farm R1 Weak Surveillance 191 1 6 This study
JR57 2015 Germany Farm R1 Weak Surveillance 191 1 6 This study
JR58 2015 Germany Farm R1 Weak Surveillance 191 1 6 This study
JR59 2015 Germany Farm R1 Weak Surveillance 191 1 6 This study
JR60 2015 Germany Farm R2 Weak Surveillance 191 1 6 This study
JR61 2015 Germany Farm R2 Weak Surveillance 191 1 6 This study
JR63 2015 Germany Farm R2 Weak Surveillance 191 1 6 This study
JR64 2015 Germany Farm R3 Weak Surveillance 191 1 6 This study
JR65 2015 Germany Farm R4 Weak Diarrhoea 191 1 6 This study
JR76 2016 Germany Farm R4 Weak Diarrhoea 191 1 6 This study
JR49 2015 Germany Farm R1 Weak Surveillance 192 1 7 This study
JR50 2015 Germany Farm R1 Weak Surveillance 192 1 7 This study
JR71 2016 Germany Farm W2 Weak Surveillance 219 1 8 This study
AWT1-5 2016 Germany Farm W1 Weak Surveillance 219 1 8 This study
AWT1-3 2016 Germany Farm W2 Weak Surveillance 219 1 8 This study
AWT1-6 2016 Germany Farm W3 Weak Surveillance 219 1 8 This study
AWT1-7 2016 Germany Farm W3 Weak Surveillance 219 1 8 This study
JR79 2015 Germany Farm W4 Weak Diarrhoea 219 1 8 This study
JR80 2015 Germany Farm W4 Weak Diarrhoea 219 1 8 This study
JR73 2017 Germany Farm Z Weak Surveillance Partial1 4 9 This study
JR74 2017 Germany Farm Z Weak Surveillance Partial1 4 9 This study
JR77 2016 Germany Farm I Weak Surveillance Partial2 4 10 This study
JR72 2017 Germany Farm II Weak/stronga Surveillance Partial3 1 n/a This study
AWT2–4 2015 Spain Farm X Strong Swine dysentery Partial4 4 n/a This study
JR22 2014 Germany Farm N Strong Diarrhoea 52 1 n/a This study
JR31 2014 Germany Farm O Strong Unknown 112 4 n/a This study
JR32 2014 Germany Farm P Strong Diarrhoea 52 1 n/a This study
JR42 2014 Germany Farm Q Strong Diarrhoea 139 4 n/a This study
JR96 2015 Germany Farm S Strong Swine dysentery 52 1 n/a This study
JR97 2015 Germany Farm T Strong Swine dysentery 52 1 n/a This study
JR98 2015 Germany Farm U Strong Swine dysentery 112 4 n/a This study
  1. Details of the four previously sequenced weakly haemolytic B. hyodysenteriae are included for comparison. Farm of origin is given as an anonymised letter code, together with year of sampling, country of origin and haemolysis phenotype on TSA plates. Sequence type (ST), clone number, and plasmid type (PT) are indicated.
  2. aIsolate JR72 was weakly haemolytic on TSA plates, but strongly haemolytic in an in vitro haemolysis assay at high optical density (OD600 = 0.550 ± 0.05).
  3. Partial1 (adh not detected; alp: not detected; est3; gdh21; glpK40; pgm2; thi21).
  4. Partial2 (adh not detected; alp not detected; est29; gdh1; glpK10; pgm~22; thi38).
  5. Partial3 (adh2; alp not detected; est~11; gdh7; glpK8; pgm3; thi17).
  6. Partial4 (adh2; alp not detected; est5; gdh19; glpK~19; pgm3; thi3).