Transmission studies of chronic wasting disease to transgenic mice overexpressing human prion protein using the RT-QuIC assay

Table 3 Summary of prion disease test results from tg66 and tgRM mice inoculated with CWD

Mouse strain	Inoculum	RT-QuIC^a	IHC^b	WB^c
Tg66	Elk-2	2/17	0/13	0/11
Tg66	MD-1	0/18	0/8	0/2
Tg66	WTD-1	2/15	0/14	0/3
Tg66	None	0/14	0/6	0/3
TgRM	Elk-2	0/14	0/7	0/3
TgRM	MD-1	0/13	0/9	0/2
TgRM	WTD-1	0/11	0/9	0/3
TgRM	None	0/4	0/3	0/1

^aThe number of RT-QuIC mice with results significantly different than uninfected controls is shown over the total number of mice screened from the group.
^bThe number of mice positive for neuropathology including abnormal prion protein accumulation, spongiform degeneration and astrogliosis over the number tested.
^cThe number of mice that were positive for PrPres in brain by immunoblot over the number tested.

ISSN: 1297-9716