Figure 2From: Low levels of classical BSE infectivity in rendered fat tissueDiscriminatory immunoblot and IHC of positive mouse inoculated with rendered fat. Inocula was prepared from the CMGC of the clinical cow IT49, 36 mpi. Typical for BSE (A) C-terminal antibody mab L42 shows a clear signal of PrPSc but not (B) N-terminal antibody mab P4, only the scrapie control can be detected. Additionally the same brain reveals clear plaque-like PrPSc accumulation in particular in the Corpus Callosum (C) and mid brain (D), immunohistochemistry, mab R145.Back to article page