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Table 3 Transmission of the CH1641-like scrapie isolate (Sh294) to TgBoPrP mice

From: Interspecies transmission to bovinized transgenic mice uncovers new features of a CH1641-like scrapie isolate

Source

Recipient

Passage #

Survival perioda

n/n bo

Sh294 brain (CH1641-like Scrapie)

TgBoPrP

3

172 ± 4.5*

11/11

Cattle L-BSE brain

TgBoPrP

3

144 ± 4.8*

12/12

Cattle C-BSE brain

TgBoPrP

3

195 ± 4.6

14/14

Cattle H-BSE brain

TgBoPrP

3

220 ± 4.3

11/11

  1. aSurvival periods are shown as mean survival days ± standard deviation.
  2. bNumber of PrPres-positive mice out of the total number of challenged mice. All inoculated mice showed unique clinical signs of the disease (Sh294 and L-BSE, circling behavior; C-BSE, head twitching; H-BSE, constant chewing of the bedding).
  3. P < 0.0001.