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Table 3 Transmission of the CH1641-like scrapie isolate (Sh294) to TgBoPrP mice

From: Interspecies transmission to bovinized transgenic mice uncovers new features of a CH1641-like scrapie isolate

Source Recipient Passage # Survival perioda n/n bo
Sh294 brain (CH1641-like Scrapie) TgBoPrP 3 172 ± 4.5* 11/11
Cattle L-BSE brain TgBoPrP 3 144 ± 4.8* 12/12
Cattle C-BSE brain TgBoPrP 3 195 ± 4.6 14/14
Cattle H-BSE brain TgBoPrP 3 220 ± 4.3 11/11
  1. aSurvival periods are shown as mean survival days ± standard deviation.
  2. bNumber of PrPres-positive mice out of the total number of challenged mice. All inoculated mice showed unique clinical signs of the disease (Sh294 and L-BSE, circling behavior; C-BSE, head twitching; H-BSE, constant chewing of the bedding).
  3. * P < 0.0001.
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Veterinary Research

ISSN: 1297-9716