Characterization of peritoneal cells from cats with experimentally-induced feline infectious peritonitis (FIP) using RNA-seq

Table 3 Differential expression profile of genes involved in M1 macrophage polarization in peritoneal exudate cells from cats with FIP compared to peritoneal cells from healthy cats

Gene symbol	Description	Log₂FC	P _adjusted
IL6	Interleukin 6	4.86971	0.0006
NOS2	Nitric oxide synthase 2, inducible	4.21906	2.16E−05
NFKB2	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	4.14805	5.83E−16
IL12B	Interleukin 12B	3.83085	2.91E−06
RELB	v-rel avian reticuloendotheliosis viral oncogene homolog B	3.73979	2.65E−16
STAT1	Signal transducer and activator of transcription 1, 91 kDa	2.58559	2.72E−11
STAT2	Signal transducer and activator of transcription 2, 113 kDa	2.25218	5.60E−09
JAK2	Janus kinase 2	2.00000	4.96E−07
TLR4	Toll-like receptor 4	1.90593 ^a	8.94E−07
NFKB1	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	1.70639	1.07E−05
RELA	v-rel avian reticuloendotheliosis viral oncogene homolog A	1.48184	0.00019
CIITA	Class II, major histocompatibility complex, transactivator	1.41143	0.00014
CSF2RB	Colony stimulating factor 2 receptor, beta, low-affinity (granulocyte–macrophage)	1.36877	0.0252
IRF3	Interferon regulatory factor 3	0.99868	0.01143
MAPK14	Mitogen-activated protein kinase 14	0.51622	0.27282
IFNGR1	IFN-g receptor 1	0.46379	0.39809
IRF5	Interferon regulatory factor 5	0.23661	0.69315

Genes listed in italics print were significantly up-regulated. No genes were significantly down-regulated.
The list was adapted from a previous publication [70].
^aSlightly less than Log₂FC cutoff but P value highly significant.

ISSN: 1297-9716