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Table 3 Differential expression profile of genes involved in M1 macrophage polarization in peritoneal exudate cells from cats with FIP compared to peritoneal cells from healthy cats

From: Characterization of peritoneal cells from cats with experimentally-induced feline infectious peritonitis (FIP) using RNA-seq

Gene symbol Description Log2FC P adjusted
IL6 Interleukin 6 4.86971 0.0006
NOS2 Nitric oxide synthase 2, inducible 4.21906 2.16E−05
NFKB2 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 4.14805 5.83E−16
IL12B Interleukin 12B 3.83085 2.91E−06
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.73979 2.65E−16
STAT1 Signal transducer and activator of transcription 1, 91 kDa 2.58559 2.72E−11
STAT2 Signal transducer and activator of transcription 2, 113 kDa 2.25218 5.60E−09
JAK2 Janus kinase 2 2.00000 4.96E−07
TLR4 Toll-like receptor 4 1.90593 a 8.94E−07
NFKB1 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.70639 1.07E05
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.48184 0.00019
CIITA Class II, major histocompatibility complex, transactivator 1.41143 0.00014
CSF2RB Colony stimulating factor 2 receptor, beta, low-affinity (granulocyte–macrophage) 1.36877 0.0252
IRF3 Interferon regulatory factor 3 0.99868 0.01143
MAPK14 Mitogen-activated protein kinase 14 0.51622 0.27282
IFNGR1 IFN-g receptor 1 0.46379 0.39809
IRF5 Interferon regulatory factor 5 0.23661 0.69315
  1. Genes listed in italics print were significantly up-regulated. No genes were significantly down-regulated.
  2. The list was adapted from a previous publication [70].
  3. aSlightly less than Log2FC cutoff but P value highly significant.