Figure 4

Phagocytic function and respiratory burst function after IT administration of CNV-NT. Mean ± SD of the A percent cells undergoing phagocytosis of opsonized E. coli (% positive cells) and the quantity of bacteria phagocytized (MFI), B the percentage of cells undergoing respiratory burst in response to E. coli (% positive cells) and the intensity of the respiratory burst (MFI), C the percentage of cells undergoing respiratory burst in response to PMA (% positive cells) and the intensity of respiratory burst (MFI) at time 0 (pretreatment), and then at 2, 30 and 56 days post IT CNV-NT spore administration. There was a significant difference in the percent cells undergoing phagocytosis between baseline and 2 days (P = 0.009) (a), 30 days (P = 0.006) (b) and 56 days (P = 0.006) (c) and the percent cells undergoing E. coli-induced respiratory burst at 2 days (P = 0.008) (d), 30 days (P < 0.001) (e) and 56 days (P < 0.001) (f).