Figure 6From: The C3HeB/FeJ mouse model recapitulates the hallmark of bovine tuberculosis lung lesions following Mycobacterium bovis aerogenous infection Progression of total lung lesion burden and Type heterogeneity following the course of M. bovis infection. A Morphometric analysis of the total lesion area performed on H&E-stained sections of the global lung (5 lobes) of mice following intranasal infection with M. bovis. Histograms represent the mean percentage of lesion area within the total lung ± s.e.m at 1 to 9 weeks post-infection (n = 5 to 8 mice per time point). B High resolution scanned slides of H&E stained lung from representative C3HeB/FeJ mice at different weeks post-infection (W3 to W9) showing the characteristic evolution of Type I (top images), Type II (middle images) and Type III (down images) lesions over the course of infection. C Histometric analysis of the relative percentage of each Type of lesion within the total lesion area performed on H&E-stained sections of the global lung (5 lobes) of mice following intranasal infection with M. bovis. Histograms represent the mean percentage of each lesion Type over the total percentage (100%) of lesion area ± s.e.m at 1 to 9 weeks post-infection (n = 5 to 8 mice per time point). The dotted rectangle indicate the presence, at a low rate (0.7%), of emerging Type I lesions as soon as 5 weeks post-infection. The dotted red line delimitates the critical early phase of infection (week 5).Back to article page