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Table 2 Distribution of CZ and JY viruses and their recombinants with single or double substitutions in the PB2 in mouse organs at 3 and 5 dpi

From: Synergistic effect of PB2 283M and 526R contributes to enhanced virulence of H5N8 influenza viruses in mice

Virus Virus titer (log10EID50/mL ± SD)
Heart Liver Spleen Lung Kidney Brain
3 dpi 5 dpi 3 dpi 5 dpi 3 dpi 5 dpi 3 dpi 5 dpi 3 dpi 5 dpi 3 dpi 5 dpi
r-CZ 1.88 ± 0.53 2.88 ± 0.53   2.50 ± 0.00 2.63 ± 0.18 1.93 ± 0.13 5.88 ± 0.53 6.40 ± 0.50 1.50 ± 0.35 2.00 ± 0.71 2.00 ± 0.35 5.25 ± 0.00
CZPB2-M283I 2.63 ± 0.18 2.00 ± 0.35 4.13 ± 0.58 3.38 ± 0.18
CZPB2-R526K 2.03 ± 0.03   3.13 ± 0.53 2.88 ± 0.53 5.88 ± 0.53 5.88 ± 0.53 1.25 ± 0.00 1.88 ± 0.18 2.50 ± 0.35
CZPB2-M283I-R526K 1.38 ± 0.53 1.50 ± 0.00 4.63 ± 0.18 2.88 ± 0.88
r-JY 3.63 ± 0.13 4.13 ± 0.38
JYPB2-I283M 4.63 ± 0.18 4.88 ± 0.53
JYPB2-P321S 1.25 ± 0.00 4.63 ± 0.18 4.13 ± 0.63 1.38 ± 0.18
JYPB2-K526R 1.75 ± 0.00 4.50 ± 0.00 4.88 ± 0.53
JYPB2-V529I 3.38 ± 0.18 3.63 ± 0.18
JYPB2-I283M-K526R 2.00 ± 0.35 1.38 ± 0.18 6.13 ± 0.53 4.50 ± 0.71 1.50 ± 0.35