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Table 2 Data concerning the effectiveness of the oral challenges in goats with bovine (1 st passage) and caprine (2 nd passage) BSE

From: Protecting effect of PrP codons M142 and K222 in goats orally challenged with bovine spongiform encephalopathy prions

Genotype Numbers Numbers from 12 mpi Inc. time clinical, mpi ±SD (n)
Total Before 12 mpi After 12 mpi Pre-clinical Late preclinical Clinical Attack ratios affected/total (%) + significancea
bovBSE
 wt 24 6 18 3 2 5 10/18 (56%) 25.2 ± 0.4 (5)
 I/M142 10 2 8 0 0 2 2/8 (25%)** 44.5 ± 0.7 (2)
 M/M142 4 0 4 0 1 0 1/4 (25%) NA
 R/Q211 12 3 9 0 5 3 8/9 (89%) 30.7 ± 2.1 (3)
 Q/K222 12 3 9 0 1b 0 1/9 (11%)** NA
gtBSE
 wt 26 6 20 2 3 5 10/20 (50%) 25.6 ± 1.5 (5)
 I/M142 11 3 8 0 0 0 0/8 (0%)* NA
 R/Q211 11 4 7 1 0 3 4/7 (57%) 34.3 ± 1.5 (3)
 Q/K222 11 3 8 0 1c 0 1/8 (13%)c* NA
Genotype Total mpi Numbers from 12 mpi Inc. time clinical, mpi ±SD (n)
1st clin case Last clin case Pre-clinical Late preclinical Clinical Attack ratios affected/total (%) + significance
Combined challenges
 wt 50 24 28 5 5 10 20/38 (53%) 25.4 ± 1.1 (10)
 I/M142 21 44 45 0 0 2 2/16 (13%)** 44.5 ± 0.7 (2)
 M/M142 4 NA NA NA NA NA NA NA
 R/Q211 23 28 36 1 5 6 12/16 (75%) 32.5 ± 2.6 (6)
 Q/K222 23 43 NA 0 2 0 2/17 (12%)*** NA
  1. NA, not applicable.
  2. aStatistical data: compared to the wild type group. Fisher’s exact test, *, **, and *** respectively p < 0.05, p < 0.01, p < 0.001.
  3. bThis Q/K222 goat was CNS- and muscle-positive.
  4. cOne Q/K222 case was CNS-positive, and psoas-muscle-positive but by mouse bioassay (Tg110) only [33]. If considered negative (by IHC) this group was statistically positive compared to the wild type group (p < 0.05).