Figure 2

Overview of the results of challenge with goat BSE (= 2 ^nd passage) in goats with four different genotypes. Each symbol represents an individual goat. Symbol colours and arrows are explained in Figure 1. Symbol shapes represent the laboratory of experiment: triangles lab 2, and squares lab 3. The two arrows under the X-axis: open and bold indicate respectively the month after inoculation at which respectively the first preclinical and clinical cases were observed. Small arrow near one Q/K222 symbol is reflecting the animal previously found weakly brain (only) positive in infectivity testing in Tg110 mice [33].