Figure 4From: Attenuation of the virulence of a recombinant influenza virus expressing the naturally truncated NS gene from an H3N8 equine influenza virus in mice Cytokine levels in mice infected with the recombinant viruses. The concentrations of induced cytokines and chemokines were determined in the infected mice (n = 3). Levels of (A) IL-6, (B) CCL5, and (C) IFN-γ were measured in bronchoalveolar lavage fluids harvested at 3, 5, 7, and 9 dpi. Asterisks indicate statistically significant differences between groups (*P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; and ****P ≤ 0.0001).Back to article page