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Table 1 Data and results of scrapie positive Damascus goats from Cyprus

From: Genetic, histochemical and biochemical studies on goat TSE cases from Cyprus

Goat ZYP Flock (age) Brain stem CM GC Ln. retroph. Tonsil 3rd eye lid Spleen Rectum Placenta
IHC  (rapid test) Follicles ENS
I142N146R151R154R211Q222
3 B (4) +++ 
(1.892)
+ NA +++
9/9
+++
13/19
++
83/202
+++
1/1
neg. neg.
8 C (4) +++
(1.675)
NA +++
4/4
neg.
0/5
+++
7/12
+
6/140
neg.
0/3
+
Pl.my.
NA
9 D (4) ++ 
(1.579)
++ +++
625/830
+++
96/120
+++
35/64
+++
110/162
+++
19/24
neg. neg.
10 E (3) +++ 
(1.985)
NA +++
232/646
++
124/213
+++
5/18
+
93/428
+++
37/48
+
Pl.my.
neg.
11 F (4) +++ 
(1.856)
+ +
93/284
+++
124/255
neg.
0/18
+
10/374
neg.
0/19
+
Pl.my.
neg.
12 G (3) +++ 
(2.193)
++ ++
190/502
0 +
9/46
+
126/396
++
71/152
neg. neg.
13 G (4) +++ 
(1.992)
+++ +
87/365
+++
111/145
+++
4/4
+++
56/99
+++
131/174
++ 
Pl.my/+sub.
NA
14 F (4) +++ 
(1.871)
+++ +++
77/139
++
174/307
+++
5/5
+++
167/246
+++
28/46
++ 
Pl.my/+sub.
neg.
16 H (4) +++ 
(2.204)
+++ +
147/363
+
20/78
+
1/10
+
64/270
++
19/47
+
Pl.my/+sub.
NA
17 H (4) +++ 
(2.107)
++ ++
119/300
+++
72/132
+++
15/17
+
65/160
+++
29/43
+
Pl.my.
NA
19 H (4) ++ 
(1.831)
+ ++
50/131
+
15/82
+
1/9
+++
148/234
+++
2/2
++
Pl.my.
NA
20 I (3) +++ 
(1.961)
+ ++
18/57
+++
268/335
+
2/7
++
123/373
+++
26/43
++
Pl.my/+sub.
neg.
21 J (5) ++ 
(1.511)
+++ +
190/615
NA +
4/41
++ 
175/314
+
20/37
+++ 
Pl.my/+sub.
+
22 J (5) ++ 
(1.151)
NA NA +++
65/96
neg.
0/2
+
42/269
+
1/41
+
Pl.my.
NA
25 K (3) ++ 
(1.227)
++ +
278/654
+++
376/585
+++
3/4
++
173/339
++
4/14
++ 
Pl.my/+sub.
NA
26 L (4) ++ 
(1.731)
+ +++
196/302
0 neg.
0/26
+
133/571
+
55/146
+++
Pl.sub.
+
27 M (3) ++ 
(1.141)
+ +++
229/344
+++
41/65
+++
17/23
+++
82/152
++
10/28
+++
Pl.my/+sub.
+
29 M (4) ++ 
(1.921)
++ +++
180/313
+
290/459
+++
67/85
+++
125/128
+++
21/37
++ 
Pl.my/+sub.
neg.
30 M (6) +++ 
(1.246)
++ ++
90/286
+++
72/139
neg.
0/2
+
81/224
+++
17/22
+
Pl.my/+sub.
neg.
31 N (4) ++ 
(1.255)
++ +++
264/398
+++
131/144
+++
26/55
++
169/366
+++
66/92
+++ 
Pl.my/+sub.
neg.
33 O (2) ++ 
(1.784)
++ +++
136/262
+++
141/164
++
3/10
++
257/503
+++
30/39
++ 
Pl.my/+sub.
NA
34 P (2) ++ 
(1.376)
+++ +++
626/878
+++
191/256
+++
8/9
+++
228/292
+++
6/7
+
Pl.my.
NA
35 P (4) +++ 
(1.452)
NA +++
319/625
+++
73/147
0 +
4/208
+
9/101
+
Pl.my.
neg.
41 O (4) ++ 
(1.674)
NA ++
97/268
+++
72/102
neg.
0/14
+
60/167
0 +
Pl.my.
NA
24 K (2) neg.
(0.012)
+ +
391/1154
NA neg.
0/42
+
11/446
+
8/80
neg. NA
37 Q (3) neg.
(0.010)
+ neg.
0/168
neg.
0/73
neg.
0/8
neg.
0/149
neg
0/14
neg. NA
R/H154
40 R (4) ++ 
(1.069)
+ +
21/220
neg.
0/6
neg.
0/6
neg.
0/134
neg.
0/35
+++ 
Pl.my.
neg.
  1. D: aspartic acid; I: isoleucine; H: histidine; M: methionine; N: asparagine; Q: glutamine; R: arginine; S: serine; A–T: goat herds; age: is given in years; Cut-off BioRad rapid test: 0.213; IHC: immunohistochemistry; +, ++, +++: mild, moderate, severe PrPSc accumulation (the first number indicates the number of positive follicles, the second number the total number of follicles examined); CMGC: celiac and mesenteric ganglion complex; Ln. retroph.: retropharyngeal lymph node; 0: no lymphatic follicles; ENS: enteric nervous system; Pl. my.+sub.: myenteric/submucosal plexus; neg.: PrPSc negative; NA: tissue sample not available.