Relationships of CD163 and CD169 positive cell numbers in the endometrium and fetal placenta with type 2 PRRSV RNA concentration in fetal thymus

Table 1 Association of CD163 positive cells in the endometrium and placenta and PRRSV RNA concentration in fetal thymus

PRRS RNA concentration in fetal thymus count^e	Coefficient (SE)	95% CI	P values
Continuous model (relationship of cell numbers to PRRSV concentration in fetal thymus)
Numbers of CD163 positive cells per 1 mm² of endometrium	0.004 (0.002)^a	0.0009, 0.007	0.011
Numbers of CD163 positive cells per 1 mm² of fetal placenta	−0.002 (0.001)^b	−0.003, −0.0006	0.005
Inflated (logit) model^f (relationship of cell numbers to likelihood of PRRSV concentration in fetal thymus being equal to zero (PRSV negative)
Numbers of CD163 positive cells per 1 mm² of endometrium	−0.044 (0.012)^c	−0.067, −0.021	<0.001
Numbers of CD163 positive cells per 1 mm² of fetal placenta	0.006 (0.003)^d	0.0004, 0.011	0.033

Results of zero-inflated Poisson regression model.
^aFor each one unit increase in the numbers of CD163 positive cells/mm² of endometrium, PRRSV RNA concentration in fetal thymus increases by 0.004 log₁₀ copies/mg.
^bFor each one unit increase in the numbers of CD163 positive cells/mm² of fetal placenta PRRSV RNA concentration in the fetal thymus decreases by 0.002 log₁₀ copies/mg.
^cFor each one unit change in the numbers of CD163 positive cells/mm² of endometrium the odds of PRRSV RNA concentration in fetal thymus being equal to 0 (zero) decreases 1.045 times (e^−0.044).
^dFor each one unit change in the numbers of CD163 positive cells/mm² of fetal placenta the odds of PRRSV RNA concentration in the fetal thymus being equal to 0 (zero) increases 1.006 times (e^0.006).
^eBased on the distribution of data, a count model was used after categorizing PRRSV RNA concentration into nine 1 − log₁₀ replicates, from 0 to 9 log₁₀ copies/mg.
^fThe logit portion of the model predicts the odds of a fetus being negative (PRRSV RNA concentration = 0) from the population of fetuses from infected and negative control gilts.

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