Figure 4From: Identification and characterization of a Streptococcus equi ssp. zooepidemicus immunogenic GroEL protein involved in biofilm formation Protective efficacy by vaccination in mice. Mice were injected with S. equi spp. zooepidemicus ATCC35246 and mortality was recorded daily for 7 days. Mice in the non-immunized group died 24 to 48 h after the challenge, and the mortality rate reached 100%. Mice in the groups immunized with rGroEL or the inactivated S. equi spp. zooepidemicus vaccine died 48 to 72 h after the challenge with S. equi spp. zooepidemicus and 75% survived 7 days post-infection for these two groups. Significant differences in survival were noted, log rank test, P < 0.05. Compared with the non-immunized group, the mice in the groups immunized with rGroEL or the inactivated S. equi spp. zooepidemicus vaccine had higher survival rates (P < 0.05).Back to article page