Genome-scale structure patterns within and among three IBE eye
isolates and four IBK asymptomatic nasopharyngeal
isolates. A Gene distribution of the non-homologous IBK eye (n = 129) and IBK asymptomatic nasopharyngeal (n = 189) core genes within representative genomes. CRISPR regions are indicated with blue arrows. B Absence of genome rearrangement among individual clinical genomes. C Four >20 kbp blocks (2, 11–13) of the non-clinical genome are translocated and/or inverted (block appears beneath neighboring blocks) among Mb28389, Mb23343 and Mb33362 genomes whereas Mb22851 exhibits a single large inversion of blocks 3–10. Several breakpoints correlate with 25 phage elements (pink). D Four >25 kbp blocks (4, 5, 7 and 9) are translocated and inverted between the consensus IBK eye genome and the consensus IBK asymptomatic nasopharyngeal genome (IBK asymptomatic nasopharyngeal blocks 2, 11–13 not shown). Several breakpoints correlate with four phage elements (pink) identified within Mb57922 and Mb58069 clinical genomes.